Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations.
TY - CONF
AU - Nikolic, Ljiljana
AU - Savic, Danijela
AU - Korac Jacic, Jelena
AU - Petkovic, Branka
AU - Stojadinovic, Gordana
AU - Martac, Ljiljana
AU - Bogdanović Pristov, Jelena
PY - 2022
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2010
AB - Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations.
PB - Society of Physical Chemists of Serbia
C3 - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1 - MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION
EP - 592
SP - 589
VL - 2
UR - https://hdl.handle.net/21.15107/rcub_rimsi_2010
ER -
@conference{
author = "Nikolic, Ljiljana and Savic, Danijela and Korac Jacic, Jelena and Petkovic, Branka and Stojadinovic, Gordana and Martac, Ljiljana and Bogdanović Pristov, Jelena",
year = "2022",
abstract = "Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION",
pages = "592-589",
volume = "2",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2010"
}
Nikolic, L., Savic, D., Korac Jacic, J., Petkovic, B., Stojadinovic, G., Martac, L.,& Bogdanović Pristov, J.. (2022). MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., 2, 589-592.
https://hdl.handle.net/21.15107/rcub_rimsi_2010
Nikolic L, Savic D, Korac Jacic J, Petkovic B, Stojadinovic G, Martac L, Bogdanović Pristov J. MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;2:589-592.
https://hdl.handle.net/21.15107/rcub_rimsi_2010 .
Nikolic, Ljiljana, Savic, Danijela, Korac Jacic, Jelena, Petkovic, Branka, Stojadinovic, Gordana, Martac, Ljiljana, Bogdanović Pristov, Jelena, "MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), 2 (2022):589-592,
https://hdl.handle.net/21.15107/rcub_rimsi_2010 .
