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Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes

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2022
bitstream_4949.pdf (394.6Kb)
Authors
Štrbac, Filip
Simin, Nataša
Orčić, Dejan
Bosco, Antonio
Stojanović, Dragica
Petrović, Kosta
Ratajac, Radomir
Cringoli, Giuseppe
Rinaldi, Laura
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Abstract
The development and spread of anthelmintic resistance to commercial drugs represent a major problem in veterinary medicine, which justifies the search for alternatives. Within that context, sage (Salvia officinalis L.) is a well-known medicinal plant that has been cultivated for centuries due to its healing properties. The aim of this study was to determine the chemical composition of the sage essential oil and to evaluate its anthelmintic properties against sheep gastrointestinal nematodes. Chemical characterization was done by GC-MS analyses, and the anthelmintic potential of tested samples was evaluated by in vitro egg hatch test in a concentration range of 0.0125-50 mg/mL. The most represented identified compounds were α-thujone (38.76%), camphor (19.75%) and 1,8-cineole (8.40%), camphene (5.36%) and α-humulene (4.15%) out of a total of 27 identified compounds. The ovicidal activity of sage essential oil, reflected in the inhibition of egg hatchability of the eggs of sheep gastroi...ntestinal nematodes, varied from 15.0-89.0% depending on the used concentration, with a calculated IC50 value of 0.53 mg/mL. The obtained results indicate that the compounds from sage essential oil posess high anthelmintic properties and should be tested in further in vivo studies. Sage essential oil could find application in veterinary medicine in the context of the development of new natural anthelmintic agents for the control of sheep gastrointestinal nematodes, which could have high significance from economic point of view.

Keywords:
anthelmintic resistance / sage essential oil / chemical composition / ovicidal activity / gastrointestinal nematodes
Source:
Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry", 2022, 143-143
Publisher:
  • Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society

ISBN: 978-86-7220-124-6 (FOC)

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_rimsi_1976
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/1976
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - CONF
AU  - Štrbac, Filip
AU  - Simin, Nataša
AU  - Orčić, Dejan
AU  - Bosco, Antonio
AU  - Stojanović, Dragica
AU  - Petrović, Kosta
AU  - Ratajac, Radomir
AU  - Cringoli, Giuseppe
AU  - Rinaldi, Laura
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1976
AB  - The development and spread of anthelmintic resistance to commercial drugs represent a major problem in veterinary medicine, which justifies the search for alternatives. Within that context, sage (Salvia officinalis L.) is a well-known medicinal plant that has been cultivated for centuries due to its healing properties. The aim of this study was to determine the chemical composition of the sage essential oil and to evaluate its anthelmintic properties against sheep gastrointestinal nematodes. Chemical characterization was done by GC-MS analyses, and the anthelmintic potential of tested
samples was evaluated by in vitro egg hatch test in a concentration range of 0.0125-50 mg/mL. The most represented identified compounds were α-thujone (38.76%), camphor (19.75%) and 1,8-cineole (8.40%), camphene (5.36%) and α-humulene (4.15%) out of a total of 27 identified compounds. The ovicidal activity of sage essential oil, reflected in the inhibition of egg hatchability of the eggs of sheep gastrointestinal nematodes, varied from 15.0-89.0% depending on the used concentration, with a calculated IC50 value of 0.53 mg/mL. The obtained results indicate that the compounds from sage essential oil posess high anthelmintic properties and should be tested in further in vivo studies. Sage essential oil could find application in veterinary medicine in the context of the development of new natural anthelmintic agents for the control of sheep gastrointestinal nematodes, which could have high significance from economic point of view.
PB  - Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society
C3  - Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry"
T1  - Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes
EP  - 143
SP  - 143
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1976
ER  - 
@conference{
author = "Štrbac, Filip and Simin, Nataša and Orčić, Dejan and Bosco, Antonio and Stojanović, Dragica and Petrović, Kosta and Ratajac, Radomir and Cringoli, Giuseppe and Rinaldi, Laura",
year = "2022",
abstract = "The development and spread of anthelmintic resistance to commercial drugs represent a major problem in veterinary medicine, which justifies the search for alternatives. Within that context, sage (Salvia officinalis L.) is a well-known medicinal plant that has been cultivated for centuries due to its healing properties. The aim of this study was to determine the chemical composition of the sage essential oil and to evaluate its anthelmintic properties against sheep gastrointestinal nematodes. Chemical characterization was done by GC-MS analyses, and the anthelmintic potential of tested
samples was evaluated by in vitro egg hatch test in a concentration range of 0.0125-50 mg/mL. The most represented identified compounds were α-thujone (38.76%), camphor (19.75%) and 1,8-cineole (8.40%), camphene (5.36%) and α-humulene (4.15%) out of a total of 27 identified compounds. The ovicidal activity of sage essential oil, reflected in the inhibition of egg hatchability of the eggs of sheep gastrointestinal nematodes, varied from 15.0-89.0% depending on the used concentration, with a calculated IC50 value of 0.53 mg/mL. The obtained results indicate that the compounds from sage essential oil posess high anthelmintic properties and should be tested in further in vivo studies. Sage essential oil could find application in veterinary medicine in the context of the development of new natural anthelmintic agents for the control of sheep gastrointestinal nematodes, which could have high significance from economic point of view.",
publisher = "Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society",
journal = "Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry"",
title = "Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes",
pages = "143-143",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1976"
}
Štrbac, F., Simin, N., Orčić, D., Bosco, A., Stojanović, D., Petrović, K., Ratajac, R., Cringoli, G.,& Rinaldi, L.. (2022). Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes. in Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry"
Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society., 143-143.
https://hdl.handle.net/21.15107/rcub_rimsi_1976
Štrbac F, Simin N, Orčić D, Bosco A, Stojanović D, Petrović K, Ratajac R, Cringoli G, Rinaldi L. Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes. in Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry". 2022;:143-143.
https://hdl.handle.net/21.15107/rcub_rimsi_1976 .
Štrbac, Filip, Simin, Nataša, Orčić, Dejan, Bosco, Antonio, Stojanović, Dragica, Petrović, Kosta, Ratajac, Radomir, Cringoli, Giuseppe, Rinaldi, Laura, "Chemical Composition of Sage (Salvia officinalis L.) Essential Oil and its Anthelmintic Properties against Sheep Gastrointestinal Nematodes" in Serbian Biochemical Society Eleventh Conference (scientific meeting of an international character) - "Amazing Biochemistry" (2022):143-143,
https://hdl.handle.net/21.15107/rcub_rimsi_1976 .

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