Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties
Authors
Štrbac, Filip
Simin, Nataša

Orčić, Dejan
Bosco, Antonio
Amadesi, Alessandra
Rinaldi, Laura
Stojanović, Dragica
Pušić, Ivan
Krnjajić, Slobodan

Ratajac, Radomir
Conference object (Published version)

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Thyme (Thymus vulgaris L.) is a well-known member of the genus Thymus with healing properties known since ancient times. Thyme has application in traditional medicine and pharmaceutical preparations, but also in the food and cosmetic industry. The aim of this study was to examine the chemical composition and in vitro anthelmintic potential of thyme essential oils from Serbia and compare it with sample from France. Chemical characterization of the samples was done by GC-MS and antihelmintic potential of tested samples was evaluated using in vitro egg hatch test on sheep gastrointestinal nematodes (concentration range 0.049-50 mg/mL) for each sample. The most represented compounds in sample from Serbia were: p-cymene (41.72%), thymol (31.59%), α-terpineol (11.71%), linalool (4.37%) and α-pinene (2.47%) and it inhibited egg hatchability for 95.25-100% and in sample from France thymol (54.48%), p-cymene (21.01%), γ-terpinene (8.11%), carvacrol (3.95%) and linalool (2.77%) were the dominant... compounds and inhibited egg
hatchability for 98.5-100%. The results indicate that chemical composition of thyme essential oil is dependant on geographic origin but regardless it poseses antihelmintic potential and may be used in veterinary medicine as anthelmintic agent.
Keywords:
thyme / essential oil / GC-MS / anthelmintic activity / gastrointestinal nematodesSource:
Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms", 2021, 160-161Publisher:
- Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society
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Institut za multidisciplinarna istraživanjaTY - CONF AU - Štrbac, Filip AU - Simin, Nataša AU - Orčić, Dejan AU - Bosco, Antonio AU - Amadesi, Alessandra AU - Rinaldi, Laura AU - Stojanović, Dragica AU - Pušić, Ivan AU - Krnjajić, Slobodan AU - Ratajac, Radomir PY - 2021 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1975 AB - Thyme (Thymus vulgaris L.) is a well-known member of the genus Thymus with healing properties known since ancient times. Thyme has application in traditional medicine and pharmaceutical preparations, but also in the food and cosmetic industry. The aim of this study was to examine the chemical composition and in vitro anthelmintic potential of thyme essential oils from Serbia and compare it with sample from France. Chemical characterization of the samples was done by GC-MS and antihelmintic potential of tested samples was evaluated using in vitro egg hatch test on sheep gastrointestinal nematodes (concentration range 0.049-50 mg/mL) for each sample. The most represented compounds in sample from Serbia were: p-cymene (41.72%), thymol (31.59%), α-terpineol (11.71%), linalool (4.37%) and α-pinene (2.47%) and it inhibited egg hatchability for 95.25-100% and in sample from France thymol (54.48%), p-cymene (21.01%), γ-terpinene (8.11%), carvacrol (3.95%) and linalool (2.77%) were the dominant compounds and inhibited egg hatchability for 98.5-100%. The results indicate that chemical composition of thyme essential oil is dependant on geographic origin but regardless it poseses antihelmintic potential and may be used in veterinary medicine as anthelmintic agent. PB - Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society C3 - Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms" T1 - Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties EP - 161 SP - 160 UR - https://hdl.handle.net/21.15107/rcub_rimsi_1975 ER -
@conference{ author = "Štrbac, Filip and Simin, Nataša and Orčić, Dejan and Bosco, Antonio and Amadesi, Alessandra and Rinaldi, Laura and Stojanović, Dragica and Pušić, Ivan and Krnjajić, Slobodan and Ratajac, Radomir", year = "2021", abstract = "Thyme (Thymus vulgaris L.) is a well-known member of the genus Thymus with healing properties known since ancient times. Thyme has application in traditional medicine and pharmaceutical preparations, but also in the food and cosmetic industry. The aim of this study was to examine the chemical composition and in vitro anthelmintic potential of thyme essential oils from Serbia and compare it with sample from France. Chemical characterization of the samples was done by GC-MS and antihelmintic potential of tested samples was evaluated using in vitro egg hatch test on sheep gastrointestinal nematodes (concentration range 0.049-50 mg/mL) for each sample. The most represented compounds in sample from Serbia were: p-cymene (41.72%), thymol (31.59%), α-terpineol (11.71%), linalool (4.37%) and α-pinene (2.47%) and it inhibited egg hatchability for 95.25-100% and in sample from France thymol (54.48%), p-cymene (21.01%), γ-terpinene (8.11%), carvacrol (3.95%) and linalool (2.77%) were the dominant compounds and inhibited egg hatchability for 98.5-100%. The results indicate that chemical composition of thyme essential oil is dependant on geographic origin but regardless it poseses antihelmintic potential and may be used in veterinary medicine as anthelmintic agent.", publisher = "Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society", journal = "Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms"", title = "Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties", pages = "161-160", url = "https://hdl.handle.net/21.15107/rcub_rimsi_1975" }
Štrbac, F., Simin, N., Orčić, D., Bosco, A., Amadesi, A., Rinaldi, L., Stojanović, D., Pušić, I., Krnjajić, S.,& Ratajac, R.. (2021). Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties. in Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms" Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society., 160-161. https://hdl.handle.net/21.15107/rcub_rimsi_1975
Štrbac F, Simin N, Orčić D, Bosco A, Amadesi A, Rinaldi L, Stojanović D, Pušić I, Krnjajić S, Ratajac R. Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties. in Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms". 2021;:160-161. https://hdl.handle.net/21.15107/rcub_rimsi_1975 .
Štrbac, Filip, Simin, Nataša, Orčić, Dejan, Bosco, Antonio, Amadesi, Alessandra, Rinaldi, Laura, Stojanović, Dragica, Pušić, Ivan, Krnjajić, Slobodan, Ratajac, Radomir, "Chemical Composition of Thyme Essential Oil and its Anthelmintic Properties" in Serbian Biochemical Society Tenth Conference with international participation - "Biochemical Insights into Molecular Mechanisms" (2021):160-161, https://hdl.handle.net/21.15107/rcub_rimsi_1975 .