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In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep

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2022
bitstream_5151.pdf (1.084Mb)
Authors
Štrbac, Filip
Bosco, Antonio
Stojanović, Dragica
Simin, Nataša
Orčić, Dejan
Ratajac, Radomir
Petrović, Kosta
Cringoli, Giuseppe
Rinaldi, Laura
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Abstract
The development of anthelmintic resistance in gastrointestinal nematodes (GINs) requires the search for alternative strategies. The aim of this study was to examine in vitro and in vivo anthelmintic efficacy of essential oil (EO) of Satureja montana (L.) against GIN of sheep, as well as toxic effects in sheep, in order to evaluate the possibility of its use in the veterinary practice. In vitro Egg Hatch Test (EHT) was conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025 and 0.0125 mg/mL) of EO. In addition, for the in vivo Faecal Egg Count Reduction Test (FECRT), S. montana EO was administered orally to sheep of two different farms in southern Italy at the mean dose of 150 mg/kg. The chemical composition of EO was determined by GC-MS. In the EHT, S. montana EO showed ovicidal potential against sheep GINs with inhibition of egg hatchability that varied from 17.3-83.0% depending on the used concentration. The EO also showed in vivo anthelmintic potent...ial with the total reduction of FEC of 15.7% and 33.0% at days 7 and 14 after treatment, respectively. No toxic effects were observed during clinical evaluation, blood count and liver function tests of sheep. The main represented compounds of EO were p-cymene (42.8%), carvacrol (28.1%) and γ-terpinene (14.6%). The obtained results suggest that S. montana EO may be used in the sustainable future management of GIN infections in sheep as a complementary and sustainable method to reduce the use of chemicals and to counteract anthelmintic resistance.

Keywords:
anthelmintic resistance / gastrointestinal nematodes / essential oils / satureja montana / integrated control
Source:
Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece, 2022
Publisher:
  • COST Action COMBAR (Combatting Anthelmintic Resistance in Ruminants) - CA16230
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_rimsi_1968
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/1968
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - CONF
AU  - Štrbac, Filip
AU  - Bosco, Antonio
AU  - Stojanović, Dragica
AU  - Simin, Nataša
AU  - Orčić, Dejan
AU  - Ratajac, Radomir
AU  - Petrović, Kosta
AU  - Cringoli, Giuseppe
AU  - Rinaldi, Laura
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1968
AB  - The development of anthelmintic resistance in gastrointestinal nematodes (GINs) requires the search for alternative strategies. The aim of this study was to examine in vitro and in vivo anthelmintic efficacy of essential oil (EO) of Satureja montana (L.) against GIN of sheep, as well as toxic effects in sheep, in order to evaluate the possibility of its use in the veterinary practice. In vitro Egg Hatch Test (EHT) was conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025 and 0.0125 mg/mL) of EO. In addition, for the in vivo Faecal Egg Count Reduction Test (FECRT), S. montana EO was administered orally to sheep of two different farms
in southern Italy at the mean dose of 150 mg/kg. The chemical composition of EO was determined by GC-MS. In the EHT, S. montana EO showed ovicidal potential against sheep GINs with inhibition of egg hatchability that varied from 17.3-83.0% depending on the used concentration. The EO also showed in vivo anthelmintic potential with the total reduction of FEC of 15.7% and 33.0% at days 7 and 14 after treatment, respectively. No toxic effects were observed during clinical evaluation, blood count and liver function tests of sheep. The main represented compounds of EO were p-cymene (42.8%), carvacrol (28.1%) and γ-terpinene (14.6%). The obtained results suggest that S. montana EO may be used in the sustainable future management of GIN infections in sheep as a complementary and sustainable method to reduce the use of chemicals and to counteract anthelmintic resistance.
PB  - COST Action COMBAR (Combatting Anthelmintic Resistance in Ruminants) - CA16230
C3  - Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece
T1  - In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1968
ER  - 
@conference{
author = "Štrbac, Filip and Bosco, Antonio and Stojanović, Dragica and Simin, Nataša and Orčić, Dejan and Ratajac, Radomir and Petrović, Kosta and Cringoli, Giuseppe and Rinaldi, Laura",
year = "2022",
abstract = "The development of anthelmintic resistance in gastrointestinal nematodes (GINs) requires the search for alternative strategies. The aim of this study was to examine in vitro and in vivo anthelmintic efficacy of essential oil (EO) of Satureja montana (L.) against GIN of sheep, as well as toxic effects in sheep, in order to evaluate the possibility of its use in the veterinary practice. In vitro Egg Hatch Test (EHT) was conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025 and 0.0125 mg/mL) of EO. In addition, for the in vivo Faecal Egg Count Reduction Test (FECRT), S. montana EO was administered orally to sheep of two different farms
in southern Italy at the mean dose of 150 mg/kg. The chemical composition of EO was determined by GC-MS. In the EHT, S. montana EO showed ovicidal potential against sheep GINs with inhibition of egg hatchability that varied from 17.3-83.0% depending on the used concentration. The EO also showed in vivo anthelmintic potential with the total reduction of FEC of 15.7% and 33.0% at days 7 and 14 after treatment, respectively. No toxic effects were observed during clinical evaluation, blood count and liver function tests of sheep. The main represented compounds of EO were p-cymene (42.8%), carvacrol (28.1%) and γ-terpinene (14.6%). The obtained results suggest that S. montana EO may be used in the sustainable future management of GIN infections in sheep as a complementary and sustainable method to reduce the use of chemicals and to counteract anthelmintic resistance.",
publisher = "COST Action COMBAR (Combatting Anthelmintic Resistance in Ruminants) - CA16230",
journal = "Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece",
title = "In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1968"
}
Štrbac, F., Bosco, A., Stojanović, D., Simin, N., Orčić, D., Ratajac, R., Petrović, K., Cringoli, G.,& Rinaldi, L.. (2022). In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep. in Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece
COST Action COMBAR (Combatting Anthelmintic Resistance in Ruminants) - CA16230..
https://hdl.handle.net/21.15107/rcub_rimsi_1968
Štrbac F, Bosco A, Stojanović D, Simin N, Orčić D, Ratajac R, Petrović K, Cringoli G, Rinaldi L. In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep. in Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece. 2022;.
https://hdl.handle.net/21.15107/rcub_rimsi_1968 .
Štrbac, Filip, Bosco, Antonio, Stojanović, Dragica, Simin, Nataša, Orčić, Dejan, Ratajac, Radomir, Petrović, Kosta, Cringoli, Giuseppe, Rinaldi, Laura, "In Vitro and In Vivo Anthelmintic Efficacy of Essential Oil of Satureja montana (L.) against Gastrointestinal Nematodes of Sheep" in Book of Abstracts of COMBAR Final Conference: “Combatting anthelmintic resistance in ruminants: options for the future”, Athens, Greece (2022),
https://hdl.handle.net/21.15107/rcub_rimsi_1968 .

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