Anticancer properties of nanoceria
Апстракт
CeO2 (nanoceria) is the most important rare-earth oxide, which application is rapidly emerging. These nanoparticles are potent free radical scavengers, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on their surface. These ions are promising candidates for improving the treatment of cancers, drug delivery and catalysis. First, they collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress. Also, they show cytotoxicity, which can be manipulated for treatment of cancer cells by inducing targeted cell death with minimal toxicity to surrounding healthy cells. This dual behavior of nanoceria presents a great pharmacological potential. We established the method for synthesizing these nanoparticles. This was particularly challenging because of their low solubility. We further coated these nanoparticles with glucose to facilitate entry into the cells. Untill now, anticancer properties of nanoceria have been poorly characterized. Hence, th...e aim of this work was to investigate the cytotoxic effect of nanoceria in several cancer cell lines. Nanoceria can be beneficial for the improvement of cancer treatments and a promising candidate for further medical aplication.
Кључне речи:
Anticancer properties / CeO2 / TreatmentИзвор:
12th International PhD Student Symposium Horizons in Molecular Biology, 2015, 101-Издавач:
- International Max Planck Research School for Molecular Biology in Gottingen
Финансирање / пројекти:
- Project ID Project Title info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45012/RS// (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
Институција/група
Institut za multidisciplinarna istraživanjaTY - CONF AU - Milenković, Ivana AU - Radotić, Ksenija AU - Matović, Branko PY - 2015 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1841 AB - CeO2 (nanoceria) is the most important rare-earth oxide, which application is rapidly emerging. These nanoparticles are potent free radical scavengers, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on their surface. These ions are promising candidates for improving the treatment of cancers, drug delivery and catalysis. First, they collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress. Also, they show cytotoxicity, which can be manipulated for treatment of cancer cells by inducing targeted cell death with minimal toxicity to surrounding healthy cells. This dual behavior of nanoceria presents a great pharmacological potential. We established the method for synthesizing these nanoparticles. This was particularly challenging because of their low solubility. We further coated these nanoparticles with glucose to facilitate entry into the cells. Untill now, anticancer properties of nanoceria have been poorly characterized. Hence, the aim of this work was to investigate the cytotoxic effect of nanoceria in several cancer cell lines. Nanoceria can be beneficial for the improvement of cancer treatments and a promising candidate for further medical aplication. PB - International Max Planck Research School for Molecular Biology in Gottingen C3 - 12th International PhD Student Symposium Horizons in Molecular Biology T1 - Anticancer properties of nanoceria SP - 101 UR - https://hdl.handle.net/21.15107/rcub_rimsi_1841 ER -
@conference{ author = "Milenković, Ivana and Radotić, Ksenija and Matović, Branko", year = "2015", abstract = "CeO2 (nanoceria) is the most important rare-earth oxide, which application is rapidly emerging. These nanoparticles are potent free radical scavengers, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on their surface. These ions are promising candidates for improving the treatment of cancers, drug delivery and catalysis. First, they collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress. Also, they show cytotoxicity, which can be manipulated for treatment of cancer cells by inducing targeted cell death with minimal toxicity to surrounding healthy cells. This dual behavior of nanoceria presents a great pharmacological potential. We established the method for synthesizing these nanoparticles. This was particularly challenging because of their low solubility. We further coated these nanoparticles with glucose to facilitate entry into the cells. Untill now, anticancer properties of nanoceria have been poorly characterized. Hence, the aim of this work was to investigate the cytotoxic effect of nanoceria in several cancer cell lines. Nanoceria can be beneficial for the improvement of cancer treatments and a promising candidate for further medical aplication.", publisher = "International Max Planck Research School for Molecular Biology in Gottingen", journal = "12th International PhD Student Symposium Horizons in Molecular Biology", title = "Anticancer properties of nanoceria", pages = "101", url = "https://hdl.handle.net/21.15107/rcub_rimsi_1841" }
Milenković, I., Radotić, K.,& Matović, B.. (2015). Anticancer properties of nanoceria. in 12th International PhD Student Symposium Horizons in Molecular Biology International Max Planck Research School for Molecular Biology in Gottingen., 101. https://hdl.handle.net/21.15107/rcub_rimsi_1841
Milenković I, Radotić K, Matović B. Anticancer properties of nanoceria. in 12th International PhD Student Symposium Horizons in Molecular Biology. 2015;:101. https://hdl.handle.net/21.15107/rcub_rimsi_1841 .
Milenković, Ivana, Radotić, Ksenija, Matović, Branko, "Anticancer properties of nanoceria" in 12th International PhD Student Symposium Horizons in Molecular Biology (2015):101, https://hdl.handle.net/21.15107/rcub_rimsi_1841 .