The effect of nanoceria’s coating on their suspension stability

Abstract

Cerium oxide nanoparticles CeO2 (nanoceria) is interesting biomaterial due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. Nanoceria can protect healthy cells from oxidative stress because they are potent free radical scavenger, but they also show cytotoxicity after prolonged exposure of cells to higher concentrations. The main problem of their further biomedical application is their low solubility in water, which could be improved by coating of nanoparticles. The aim of this study was to develop appropriate methods for coating CeO2 nanoparticles with three different carbohydrates and testing the effect of coating on their suspension stability. For nanoparticles characterisation were used X-Ray and FTIR spectroscopy and SEM (scanning electron microscopy). The effect of nanoparticles' coating on their suspension stability were investigated by measuring turbidity.