The methods for nanoceria’s coating in order to improve its solubility
Abstract
CeO2 (nanoceria) is the most important rare-earth oxide and potent free radical scavenger, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. These nanoparticles can collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress, but they also show cytotoxicity. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. We established the method for synthesizing these nanoparticles, which was particularly challenging because of their low solubility. To facilitate nanoparticle’s entry into the cells, we further coated these nanoparticles with the addition of carbohydrate (glucose, levan or pullulan) in the reaction mixture during and after the synthesis of nanoceria. We investigated by which of two applied methods of synthesis gave more soluble ceria nanoparticles.
Keywords:
Nanoceria / Nanoparticle / Synthesis / Glucose / Levan / PullulanSource:
2nd International Conference ’’Modern methods of testing and evaluation in science’’, 2015, 208-Publisher:
- Scientific association for development and affirmation of new technologies
Funding / projects:
- Project ID Project Title info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45012/RS// (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
Collections
Institution/Community
Institut za multidisciplinarna istraživanjaTY - CONF AU - Milenković, Ivana AU - Radotić, Ksenija AU - Matović, Branko PY - 2015 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1826 AB - CeO2 (nanoceria) is the most important rare-earth oxide and potent free radical scavenger, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. These nanoparticles can collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress, but they also show cytotoxicity. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. We established the method for synthesizing these nanoparticles, which was particularly challenging because of their low solubility. To facilitate nanoparticle’s entry into the cells, we further coated these nanoparticles with the addition of carbohydrate (glucose, levan or pullulan) in the reaction mixture during and after the synthesis of nanoceria. We investigated by which of two applied methods of synthesis gave more soluble ceria nanoparticles. PB - Scientific association for development and affirmation of new technologies C3 - 2nd International Conference ’’Modern methods of testing and evaluation in science’’ T1 - The methods for nanoceria’s coating in order to improve its solubility SP - 208 UR - https://hdl.handle.net/21.15107/rcub_rimsi_1826 ER -
@conference{ author = "Milenković, Ivana and Radotić, Ksenija and Matović, Branko", year = "2015", abstract = "CeO2 (nanoceria) is the most important rare-earth oxide and potent free radical scavenger, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. These nanoparticles can collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress, but they also show cytotoxicity. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. We established the method for synthesizing these nanoparticles, which was particularly challenging because of their low solubility. To facilitate nanoparticle’s entry into the cells, we further coated these nanoparticles with the addition of carbohydrate (glucose, levan or pullulan) in the reaction mixture during and after the synthesis of nanoceria. We investigated by which of two applied methods of synthesis gave more soluble ceria nanoparticles.", publisher = "Scientific association for development and affirmation of new technologies", journal = "2nd International Conference ’’Modern methods of testing and evaluation in science’’", title = "The methods for nanoceria’s coating in order to improve its solubility", pages = "208", url = "https://hdl.handle.net/21.15107/rcub_rimsi_1826" }
Milenković, I., Radotić, K.,& Matović, B.. (2015). The methods for nanoceria’s coating in order to improve its solubility. in 2nd International Conference ’’Modern methods of testing and evaluation in science’’ Scientific association for development and affirmation of new technologies., 208. https://hdl.handle.net/21.15107/rcub_rimsi_1826
Milenković I, Radotić K, Matović B. The methods for nanoceria’s coating in order to improve its solubility. in 2nd International Conference ’’Modern methods of testing and evaluation in science’’. 2015;:208. https://hdl.handle.net/21.15107/rcub_rimsi_1826 .
Milenković, Ivana, Radotić, Ksenija, Matović, Branko, "The methods for nanoceria’s coating in order to improve its solubility" in 2nd International Conference ’’Modern methods of testing and evaluation in science’’ (2015):208, https://hdl.handle.net/21.15107/rcub_rimsi_1826 .