Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment.
TY - CONF
AU - Spasojević, Dragica
AU - Mutavdžić, Dragosav
AU - Simonović Radosavljević, Jasna
AU - Mitrović, Aleksandra
AU - Đikanović, Daniela
AU - Radotić, Ksenija
PY - 2022
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1749
AB - Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment.
PB - Society of Physical Chemists of Serbia
C3 - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1 - KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS
VL - 2
UR - https://hdl.handle.net/21.15107/rcub_rimsi_1749
ER -
@conference{
author = "Spasojević, Dragica and Mutavdžić, Dragosav and Simonović Radosavljević, Jasna and Mitrović, Aleksandra and Đikanović, Daniela and Radotić, Ksenija",
year = "2022",
abstract = "Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment.",
publisher = "Society of Physical Chemists of Serbia",
journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS",
volume = "2",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1749"
}
Spasojević, D., Mutavdžić, D., Simonović Radosavljević, J., Mitrović, A., Đikanović, D.,& Radotić, K.. (2022). KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., 2.
https://hdl.handle.net/21.15107/rcub_rimsi_1749
Spasojević D, Mutavdžić D, Simonović Radosavljević J, Mitrović A, Đikanović D, Radotić K. KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2022;2.
https://hdl.handle.net/21.15107/rcub_rimsi_1749 .
Spasojević, Dragica, Mutavdžić, Dragosav, Simonović Radosavljević, Jasna, Mitrović, Aleksandra, Đikanović, Daniela, Radotić, Ksenija, "KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2 (2022),
https://hdl.handle.net/21.15107/rcub_rimsi_1749 .
