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S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach
dc.creator | Dučić, Tanja | |
dc.creator | Alves, Carla | |
dc.creator | Vučinić, Željko | |
dc.creator | Lázaro-Martínez, Juan | |
dc.creator | Petković, Marijana | |
dc.creator | Soto, Juan | |
dc.creator | Mutavdžić, Dragosav | |
dc.creator | Martinez de Yuso Garcia, Maria del Valle | |
dc.creator | Radotić, Ksenija | |
dc.creator | Algarra, Manuel | |
dc.date.accessioned | 2022-08-04T10:18:36Z | |
dc.date.available | 2022-08-04T10:18:36Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0021-9797 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1558 | |
dc.description.abstract | S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives. (S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption, ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition, synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively. Computational chemistry was applied to establish the model for the most stable bond between S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat the adenocarcinoma, thus having a potential to be further developed as drug delivery systems. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200053/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS// | sr |
dc.relation | Spanish Economy and Competitivity Ministry project RTI2018-099668-BC22 | sr |
dc.relation | ANPCYT PICT 2016-1723 | sr |
dc.relation | ANPCYT PICT 2019-845 | sr |
dc.relation | Universidad de Buenos Aires (2020-2022/11BA) | sr |
dc.relation | FCT CQM Base Fund - UIDB/00674/2020 | sr |
dc.relation | Programmatic Fund - UIDP/00674/2020 | sr |
dc.relation | ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-CQM+(Madeira 14-20) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Colloid and Interface Science | sr |
dc.subject | Carbon dots | sr |
dc.subject | Cisplatin | sr |
dc.subject | Ovarian cancer | sr |
dc.title | S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.epage | 237 | |
dc.citation.issue | 623 | |
dc.citation.rank | M21~ | |
dc.citation.spage | 226 | |
dc.identifier.doi | 10.1016/j.jcis.2022.05.005 | |
dc.type.version | publishedVersion | sr |