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dc.creatorŠtrbac, Filip
dc.creatorBosco, Antonio
dc.creatorMaurelli, Maria Paola
dc.creatorRatajac, Radomir
dc.creatorStojanović, Dragica
dc.creatorSimin, Nataša
dc.creatorOrcic, Dejan
dc.creatorPusic, Ivan
dc.creatorKrnjajić, Slobodan
dc.creatorSotiraki, Smaragda
dc.creatorSaralli, Giorgio
dc.creatorCringoli, Giuseppe
dc.creatorRinaldi, Laura
dc.date.accessioned2022-04-05T15:41:58Z
dc.date.available2022-04-05T15:41:58Z
dc.date.issued2022
dc.identifier.issn2306-7381
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1548
dc.description.abstractHerbal products such as essential oils may play a promising role in the treatment of infections caused by gastrointestinal nematodes (GINs). The aim of this study was to evaluate the in vitro potential of 11 essential oils (EOs) and one binary combination of isolated EO compounds, as well as the in vivo anthelmintic efficacy of two EO formulations. Four GIN genera were identified in the coproculture examination: Haemonchus, Trichostrongylus, Teladorsagia and Chabertia. The in vitro egg hatch test (EHT) was performed at six different concentrations (50, 12.5, 3.125, 0.781, 0.195 and 0.049 mg/mL) for each EO, whereas in the in vivo faecal egg count reduction test (FECRT), each EO sample was diluted in sunflower oil and orally administrated at a dose of 100 mg/kg to the different group of animals. In the EHT, the EOs of Origanum vulgare, Foeniculum vulgare, Satureja montana, Satureja hortensis and two types of Thymus vulgaris were the most effective. The dominant compounds of these EOs were carvacrol, thymol, anethol, p-cymene and gamma-terpinene, indicating their importance for the anthelmintic activity. In the FECRT, both T. vulgaris EO type 1 and linalool:estragole combination show an anthelmintic potential with a mean effect on FECR of approximately 25%. The results suggest the possible role of tested EOs as anthelmintic agents in sheep farms, although further in vivo tests are needed.en
dc.publisherMDPI, Basel
dc.relationCOST network (Networking tool) [ECOST-STSM-CA16230-201019-113354]
dc.relationCA16230]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceVeterinary Sciences
dc.subjectphytotherapyen
dc.subjectin vivo testen
dc.subjectin vitro testen
dc.subjectgastrointestinal nematodesen
dc.subjectessential oilsen
dc.subjectanthelmintic efficacyen
dc.titleAnthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studiesen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue2
dc.citation.other9(2): -
dc.citation.rankM21
dc.citation.volume9
dc.identifier.doi10.3390/vetsci9020093
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/454/1545.pdf
dc.identifier.pmid35202346
dc.identifier.scopus2-s2.0-85125147604
dc.identifier.wos000761999200001
dc.type.versionpublishedVersion


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