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dc.creatorSposito, H.G.M.
dc.creatorLobato, A.
dc.creatorTasić, Nikola
dc.creatorMaldaner, A.O.
dc.creatorPaixão, T.R.L.C.
dc.creatorGonçalves, L.M.
dc.date.accessioned2022-04-05T15:40:27Z
dc.date.available2022-04-05T15:40:27Z
dc.date.issued2022
dc.identifier.issn1572-6657
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1526
dc.description.abstractDiltiazem is a calcium channel-blocking agent, efficient in treating various heart-related conditions and diseases. It has been used as a cutting agent in cocaine and prevents its common cardiotoxic effects. This paper presents a highly selective molecularly-imprinted sensor to detect diltiazem in buffer and urine. In addition, the possibility of using this sensor as a forensic tool for fingerprinting street-seized cocaine samples of heterogeneous composition was investigated. With thorough optimization of the fabrication process, it was possible to obtain a sensible and reproducible analytical signal via square-wave voltammetry (SWV) as the electroanalytical technique. The obtained analytical parameters for the samples in buffer, pH 7.4, were the limit of detection (LOD) of 0.12 µmol L−1, the limit of quantification (LOQ) of 0.41 µmol L−1, and inter-day reproducibility of 2%. For the samples in artificial urine, the analytical parameters were LOD of 0.26 µmol L−1, LOQ of 0.88 µmol L−1, and inter-day reproducibility of 9%. Decent linearity of the analytical signal with the increased concentration of diltiazem in the cocaine street samples suggested a high perspective of the proposed sensor for the forensic laboratory applications, more precisely, the determination of the seized samples' origins.en
dc.publisherElsevier B.V.
dc.rightsrestrictedAccess
dc.sourceJournal of Electroanalytical Chemistry
dc.subjectMolecularly imprinted polymer (MIP)en
dc.subjectForensic analysisen
dc.subjectElectroanalysisen
dc.subjectCocaine profilingen
dc.subjectAnalytical chemistryen
dc.titleSwift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic aciden
dc.typearticle
dc.rights.licenseARR
dc.citation.other911: -
dc.citation.rankM21~
dc.citation.volume911
dc.identifier.doi10.1016/j.jelechem.2022.116207
dc.identifier.scopus2-s2.0-85126030951
dc.type.versionpublishedVersion


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