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Swift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic acid
dc.creator | Sposito, H.G.M. | |
dc.creator | Lobato, A. | |
dc.creator | Tasić, Nikola | |
dc.creator | Maldaner, A.O. | |
dc.creator | Paixão, T.R.L.C. | |
dc.creator | Gonçalves, L.M. | |
dc.date.accessioned | 2022-04-05T15:40:27Z | |
dc.date.available | 2022-04-05T15:40:27Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1572-6657 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1526 | |
dc.description.abstract | Diltiazem is a calcium channel-blocking agent, efficient in treating various heart-related conditions and diseases. It has been used as a cutting agent in cocaine and prevents its common cardiotoxic effects. This paper presents a highly selective molecularly-imprinted sensor to detect diltiazem in buffer and urine. In addition, the possibility of using this sensor as a forensic tool for fingerprinting street-seized cocaine samples of heterogeneous composition was investigated. With thorough optimization of the fabrication process, it was possible to obtain a sensible and reproducible analytical signal via square-wave voltammetry (SWV) as the electroanalytical technique. The obtained analytical parameters for the samples in buffer, pH 7.4, were the limit of detection (LOD) of 0.12 µmol L−1, the limit of quantification (LOQ) of 0.41 µmol L−1, and inter-day reproducibility of 2%. For the samples in artificial urine, the analytical parameters were LOD of 0.26 µmol L−1, LOQ of 0.88 µmol L−1, and inter-day reproducibility of 9%. Decent linearity of the analytical signal with the increased concentration of diltiazem in the cocaine street samples suggested a high perspective of the proposed sensor for the forensic laboratory applications, more precisely, the determination of the seized samples' origins. | en |
dc.publisher | Elsevier B.V. | |
dc.rights | restrictedAccess | |
dc.source | Journal of Electroanalytical Chemistry | |
dc.subject | Molecularly imprinted polymer (MIP) | en |
dc.subject | Forensic analysis | en |
dc.subject | Electroanalysis | en |
dc.subject | Cocaine profiling | en |
dc.subject | Analytical chemistry | en |
dc.title | Swift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic acid | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.other | 911: - | |
dc.citation.rank | M21~ | |
dc.citation.volume | 911 | |
dc.identifier.doi | 10.1016/j.jelechem.2022.116207 | |
dc.identifier.scopus | 2-s2.0-85126030951 | |
dc.type.version | publishedVersion |