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dc.creatorOpačić, Miloš
dc.creatorRistic, Aleksandar J
dc.creatorSokic, Dragoslav
dc.creatorBaščarević, Vladimir
dc.creatorRaicević, Savo
dc.creatorSavić, Slobodan
dc.creatorZorović, Maja
dc.creatorZivin, Marko
dc.creatorSelih, Vid Simon
dc.creatorSpasojević, Ivan
dc.creatorSavić, Danijela Z
dc.date.accessioned2022-04-05T15:39:42Z
dc.date.available2022-04-05T15:39:42Z
dc.date.issued2021
dc.identifier.issn2162-3279
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1515
dc.description.abstractIntroduction Disruption of copper homeostasis and dysfunction of mitochondria have been documented in sclerotic hippocampi (HS) of patients with mesial temporal lobe epilepsy (mTLE). However, a potential link between these pathological changes has not been tackled so far. Herein, we analyzed regional distribution of neuron somata density, copper concentration, and the activity of cytochrome c oxidase (CCO), a component of mitochondrial electron transport chain and copper-containing metalloprotein, in HS. Methods Histochemical staining and laser ablation inductively coupled plasma mass spectrometry were carried out to construct comparable maps of these parameters in coronal sections of hippocampi of 3 mTLE-HS patients and 3 control subjects. Results Copper levels were decreased in all regions of HS with pyramidal neuron somata. CCO activity was significantly reduced in stratum pyramidale (PY) 1 and cornu Ammonis field 4, the two regions with significant reduction in neuron somata density. CCO activity was also lower in layers that contain apical dendrites of pyramidal neurons and mossy fibers. It appears that copper deficiency in PY2 and PY3 comes before CCO activity reduction and neuronal loss. A strong positive correlation was found between neuron density, Cu concentration, and CCO activity. Conclusions Presented results imply that pathological alterations in Cu and energy metabolism could be involved in the development of HS. A limitation of this study was the relatively small number of patients. However, presented results underline copper deficiency as a component of pathological mechanisms of epilepsy and warrant further investigation of cuproproteins and members of copper transport machinery.en
dc.publisherWiley, Hoboken
dc.relationBilateral Project of Slovenia-Serbia governments [06-00-118/2018-09/22]
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200053/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBrain and Behavior
dc.subjecttemporal lobe epilepsyen
dc.subjectMSen
dc.subjectLA&#8208en
dc.subjectICP&#8208en
dc.subjecthippocampal sclerosisen
dc.subjectcytochrome c oxidaseen
dc.subjectcopperen
dc.titleRegional distribution of cytochrome c oxidase activity and copper in sclerotic hippocampi of epilepsy patientsen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue2
dc.citation.other11(2): -
dc.citation.rankM23
dc.citation.volume11
dc.identifier.doi10.1002/brb3.1986
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/427/1512.pdf
dc.identifier.scopus2-s2.0-85097242323
dc.identifier.wos000596917400001
dc.type.versionpublishedVersion


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