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Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis

Thumbnail
2021
1509.pdf (1.670Mb)
Authors
Paunesku, Tatjana
Stevanović, Aleksandra
Popović, Jelena
Woloschak, Gayle E.
Article (Published version)
Metadata
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Abstract
Purpose: Carcinogenic effects of radiation are often assumed to be universally understood, more often than, for example, carcinogenic effects of many different chemicals. This in turn leads to an assumption that any dose of radiation, delivered at any dose rate, poses a serious health challenge. This remains an issue of dispute and low dose radiation research is focused on understanding whether these exposures contribute to cancer incidence. This review is focused on the low linear energy transfer (low LET) radiation exposures for which the data is the most abundant in recent years. Materials and methods: Review of the literature between 2008 and today, highlighting some of the most diverse studies in low dose research. Results: Low dose and low dose rate, low LET ionizing radiation animal studies suggest that the effects of exposure very much depend on animal genotype and health status. Conclusions: Only the integration of all of the data from different models and studies will lead to... a fuller understanding of low dose radiation effects. Therefore, we hope to see an increase in international archival efforts and exchange of raw data information opening the possibilities for new types of meta analyses.

Keywords:
Radiation-induced tumors / low linear energy transfer (low LET) / low dose rate / low dose effects
Source:
International Journal of Radiation Biology, 2021, 97, 6, 757-768
Publisher:
  • Taylor & Francis Ltd, Abingdon
Funding / projects:
  • NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA221150]

DOI: 10.1080/09553002.2020.1859155

ISSN: 0955-3002

PubMed: 33289582

WoS: 000605426300001

Scopus: 2-s2.0-85099278806
[ Google Scholar ]
6
2
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/1512
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - JOUR
AU  - Paunesku, Tatjana
AU  - Stevanović, Aleksandra
AU  - Popović, Jelena
AU  - Woloschak, Gayle E.
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1512
AB  - Purpose: Carcinogenic effects of radiation are often assumed to be universally understood, more often than, for example, carcinogenic effects of many different chemicals. This in turn leads to an assumption that any dose of radiation, delivered at any dose rate, poses a serious health challenge. This remains an issue of dispute and low dose radiation research is focused on understanding whether these exposures contribute to cancer incidence. This review is focused on the low linear energy transfer (low LET) radiation exposures for which the data is the most abundant in recent years. Materials and methods: Review of the literature between 2008 and today, highlighting some of the most diverse studies in low dose research. Results: Low dose and low dose rate, low LET ionizing radiation animal studies suggest that the effects of exposure very much depend on animal genotype and health status. Conclusions: Only the integration of all of the data from different models and studies will lead to a fuller understanding of low dose radiation effects. Therefore, we hope to see an increase in international archival efforts and exchange of raw data information opening the possibilities for new types of meta analyses.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Radiation Biology
T1  - Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis
EP  - 768
IS  - 6
SP  - 757
VL  - 97
DO  - 10.1080/09553002.2020.1859155
ER  - 
@article{
author = "Paunesku, Tatjana and Stevanović, Aleksandra and Popović, Jelena and Woloschak, Gayle E.",
year = "2021",
abstract = "Purpose: Carcinogenic effects of radiation are often assumed to be universally understood, more often than, for example, carcinogenic effects of many different chemicals. This in turn leads to an assumption that any dose of radiation, delivered at any dose rate, poses a serious health challenge. This remains an issue of dispute and low dose radiation research is focused on understanding whether these exposures contribute to cancer incidence. This review is focused on the low linear energy transfer (low LET) radiation exposures for which the data is the most abundant in recent years. Materials and methods: Review of the literature between 2008 and today, highlighting some of the most diverse studies in low dose research. Results: Low dose and low dose rate, low LET ionizing radiation animal studies suggest that the effects of exposure very much depend on animal genotype and health status. Conclusions: Only the integration of all of the data from different models and studies will lead to a fuller understanding of low dose radiation effects. Therefore, we hope to see an increase in international archival efforts and exchange of raw data information opening the possibilities for new types of meta analyses.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Radiation Biology",
title = "Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis",
pages = "768-757",
number = "6",
volume = "97",
doi = "10.1080/09553002.2020.1859155"
}
Paunesku, T., Stevanović, A., Popović, J.,& Woloschak, G. E.. (2021). Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis. in International Journal of Radiation Biology
Taylor & Francis Ltd, Abingdon., 97(6), 757-768.
https://doi.org/10.1080/09553002.2020.1859155
Paunesku T, Stevanović A, Popović J, Woloschak GE. Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis. in International Journal of Radiation Biology. 2021;97(6):757-768.
doi:10.1080/09553002.2020.1859155 .
Paunesku, Tatjana, Stevanović, Aleksandra, Popović, Jelena, Woloschak, Gayle E., "Effects of low dose and low dose rate low linear energy transfer radiation on animals - review of recent studies relevant for carcinogenesis" in International Journal of Radiation Biology, 97, no. 6 (2021):757-768,
https://doi.org/10.1080/09553002.2020.1859155 . .

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