Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources

2021
Аутори
Anicic, Neda
Gasic, Uros
Lu, Feng
Ciric, Ana

Ivanov, Marija

Jevtic, Bojan

Dimitrijević, Milena

Anđelković, Boban
Skoric, Marijana

Nestorović-Živković, Jasmina M
Mao, Yingle
Liu, Jia
Tang, Chunping
Soković, Marina

Ye, Yang
Misic, Danijela

Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displa...yed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
Кључне речи:
nepetalactone / Nepeta / immunomodulatory effects / antimicrobial activity / antibiofilm / 1,5,9-epideoxyloganic acidИзвор:
Pharmaceuticals, 2021, 14, 5Издавач:
- MDPI, Basel
Финансирање / пројекти:
- President's International Fellowship Initiative (PIFI) grant (2019), Fellowship from the Chinese Academy of Sciences (CAS)
- Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-200007)
- Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-200007)
DOI: 10.3390/ph14050414
ISSN: 1424-8247
PubMed: 33925239
WoS: 000654389200001
Scopus: 2-s2.0-85105960331
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Anicic, Neda AU - Gasic, Uros AU - Lu, Feng AU - Ciric, Ana AU - Ivanov, Marija AU - Jevtic, Bojan AU - Dimitrijević, Milena AU - Anđelković, Boban AU - Skoric, Marijana AU - Nestorović-Živković, Jasmina M AU - Mao, Yingle AU - Liu, Jia AU - Tang, Chunping AU - Soković, Marina AU - Ye, Yang AU - Misic, Danijela PY - 2021 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1485 AB - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products. PB - MDPI, Basel T2 - Pharmaceuticals T1 - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources IS - 5 VL - 14 DO - 10.3390/ph14050414 ER -
@article{ author = "Anicic, Neda and Gasic, Uros and Lu, Feng and Ciric, Ana and Ivanov, Marija and Jevtic, Bojan and Dimitrijević, Milena and Anđelković, Boban and Skoric, Marijana and Nestorović-Živković, Jasmina M and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Misic, Danijela", year = "2021", abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.", publisher = "MDPI, Basel", journal = "Pharmaceuticals", title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources", number = "5", volume = "14", doi = "10.3390/ph14050414" }
Anicic, N., Gasic, U., Lu, F., Ciric, A., Ivanov, M., Jevtic, B., Dimitrijević, M., Anđelković, B., Skoric, M., Nestorović-Živković, J. M., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Misic, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals MDPI, Basel., 14(5). https://doi.org/10.3390/ph14050414
Anicic N, Gasic U, Lu F, Ciric A, Ivanov M, Jevtic B, Dimitrijević M, Anđelković B, Skoric M, Nestorović-Živković JM, Mao Y, Liu J, Tang C, Soković M, Ye Y, Misic D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5). doi:10.3390/ph14050414 .
Anicic, Neda, Gasic, Uros, Lu, Feng, Ciric, Ana, Ivanov, Marija, Jevtic, Bojan, Dimitrijević, Milena, Anđelković, Boban, Skoric, Marijana, Nestorović-Živković, Jasmina M, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Misic, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021), https://doi.org/10.3390/ph14050414 . .