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dc.creatorOalde, Mariana
dc.creatorKolarević, Stoimir
dc.creatorŽivković, Jelena
dc.creatorAlimpic-Aradski, Ana
dc.creatorJovanović-Marić, Jovana
dc.creatorKracun-Kolarević, Margareta
dc.creatorĐorđević Aleksić, Jelena
dc.creatorMarin, Petar D.
dc.creatorSavikin, Katarina
dc.creatorVukovic-Gacic, Branka
dc.creatorDuletic-Lausević, Sonja
dc.date.accessioned2022-04-05T15:35:29Z
dc.date.available2022-04-05T15:35:29Z
dc.date.issued2021
dc.identifier.issn2042-6496
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1454
dc.description.abstractThis research was aimed to assess the potential of Glechoma hederacea, Hyssopus officinalis, Lavandula angustifolia, Leonurus cardiaca, Marrubium vulgare and Sideritis scardica (Lamiaceae) methanolic, ethanolic and aqueous extracts against the damaging effects of oxidative stress using different experimental models. The chemical characterization was done spectrophotometrically by quantifying total phenolics, phenolic acids, flavonoids and flavonols in the extracts, as well as by employing HPLC-DAD technique. Moreover, DPPH assay was used to assess the extracts' radical scavenging potential. Genoprotective properties of the extracts were evaluated using plasmid pUC19 Escherichia coli XL1-Blue, whereas their antigenotoxic potential was determined using Salmonella typhimurium TA1535/pSK1002 and normal human lung fibroblasts. All of the extracts showed antioxidant activity in DPPH assay. Furthermore, the results have shown that aqueous extracts provided the best protection for plasmid DNA, while alcoholic extracts most effectively contributed to the preservation of prokaryotic DNA. Additionally, each of the tested samples significantly protected the eukaryotic cells against genomic damages. Finally, despite not showing exceptional results in DPPH assay, S. scardica extracts are regarded as the most favorable in maintaining the integrity of DNA, which might be due to high quantities of phenolics such as quercetin (up to 17.95 mg g(-1)), naringin (up to 5.07 mg g(-1)) and luteolin-7-O-glucoside (up to 3.54 mg g(-1)). Overall, this comprehensive concept highlights the ability of these Lamiaceae species to safeguard the DNA from reactive oxygen species, to curtail the inflicted damage and also improve the efficiency of the DNA repair mechanisms, while emphasizing the importance of polyphenols as their active principles.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//
dc.rightsrestrictedAccess
dc.sourceFood & Function
dc.subjectLamiaceae species
dc.titleA comprehensive assessment of the chemical composition, antioxidant, genoprotective and antigenotoxic activities of Lamiaceae species using different experimental models in vitroen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage3245
dc.citation.issue7
dc.citation.other12(7): 3233-3245
dc.citation.rankM21~
dc.citation.spage3233
dc.citation.volume12
dc.identifier.doi10.1039/d1fo00447f
dc.identifier.pmid33877247
dc.identifier.scopus2-s2.0-85104157452
dc.identifier.wos000631800200001
dc.type.versionpublishedVersion


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