In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.
TY - JOUR
AU - Spasojević, Ivan
AU - Maksimović, Vuk
AU - Zakrzewska, Joanna
AU - Bačić, Goran
PY - 2005
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/140
AB - In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.
PB - Amer Chemical Soc, Washington
T2 - Journal of Chemical Information and Modeling
T1 - Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning
EP - 1685
IS - 6
SP - 1680
VL - 45
DO - 10.1021/ci0501746
ER -
@article{
author = "Spasojević, Ivan and Maksimović, Vuk and Zakrzewska, Joanna and Bačić, Goran",
year = "2005",
abstract = "In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Chemical Information and Modeling",
title = "Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning",
pages = "1685-1680",
number = "6",
volume = "45",
doi = "10.1021/ci0501746"
}
Spasojević, I., Maksimović, V., Zakrzewska, J.,& Bačić, G.. (2005). Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning. in Journal of Chemical Information and Modeling
Amer Chemical Soc, Washington., 45(6), 1680-1685.
https://doi.org/10.1021/ci0501746
Spasojević I, Maksimović V, Zakrzewska J, Bačić G. Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning. in Journal of Chemical Information and Modeling. 2005;45(6):1680-1685.
doi:10.1021/ci0501746 .
Spasojević, Ivan, Maksimović, Vuk, Zakrzewska, Joanna, Bačić, Goran, "Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning" in Journal of Chemical Information and Modeling, 45, no. 6 (2005):1680-1685,
https://doi.org/10.1021/ci0501746 . .
