The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
2020
Autori
Stojadinović, GordanaMartać, Ljiljana
Podgorac, Jelena
Spasić, Slađana
Petković, Branka
Sekulic, Slobodan
Kesic, Srdjan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlat...ion with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
Ključne reči:
spectral analysis / Nembutal / intracerebellar EEG / fractal analysisIzvor:
Archives of Biological Sciences, 2020, 72, 3, 425-432Izdavač:
- Srpsko biološko društvo, Beograd, i dr.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200053 (Univerzitet u Beogradu, Institut za multidisciplinarna istraživanja) (RS-MESTD-inst-2020-200053)
DOI: 10.2298/ABS200524036S
ISSN: 0354-4664
WoS: 000583939900013
Scopus: 2-s2.0-85096374881
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Stojadinović, Gordana AU - Martać, Ljiljana AU - Podgorac, Jelena AU - Spasić, Slađana AU - Petković, Branka AU - Sekulic, Slobodan AU - Kesic, Srdjan PY - 2020 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1386 AB - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis EP - 432 IS - 3 SP - 425 VL - 72 DO - 10.2298/ABS200524036S ER -
@article{ author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana and Petković, Branka and Sekulic, Slobodan and Kesic, Srdjan", year = "2020", abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis", pages = "432-425", number = "3", volume = "72", doi = "10.2298/ABS200524036S" }
Stojadinović, G., Martać, L., Podgorac, J., Spasić, S., Petković, B., Sekulic, S.,& Kesic, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 72(3), 425-432. https://doi.org/10.2298/ABS200524036S
Stojadinović G, Martać L, Podgorac J, Spasić S, Petković B, Sekulic S, Kesic S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432. doi:10.2298/ABS200524036S .
Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana, Petković, Branka, Sekulic, Slobodan, Kesic, Srdjan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432, https://doi.org/10.2298/ABS200524036S . .