Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias

2020
Authors
Bogdanović Pristov, Jelena
Opačić, Miloš

Bajčetić, Milica
Mandic, Vesna
Maglic, Dragana
Miković, Zeljko
Spasojević, Ivan

Article (Published version)
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Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxi...dation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.
Source:
PLoS One, 2020, 15, 6Publisher:
- Public Library Science, San Francisco
Funding / projects:
- Modulation of antioxidative metabolism in plants for improvement of plant abiotic stress tolerance and identification of new biomarkers for application in remediation and monitoring of degraded biotopes (RS-43010)
- Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)
DOI: 10.1371/journal.pone.0234253
ISSN: 1932-6203
PubMed: 32555583
WoS: 000542759600044
Scopus: 2-s2.0-85086703521
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Institut za multidisciplinarna istraživanjaTY - JOUR AU - Bogdanović Pristov, Jelena AU - Opačić, Miloš AU - Bajčetić, Milica AU - Mandic, Vesna AU - Maglic, Dragana AU - Miković, Zeljko AU - Spasojević, Ivan PY - 2020 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1316 AB - Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications. PB - Public Library Science, San Francisco T2 - PLoS One T1 - Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias IS - 6 VL - 15 DO - 10.1371/journal.pone.0234253 ER -
@article{ author = "Bogdanović Pristov, Jelena and Opačić, Miloš and Bajčetić, Milica and Mandic, Vesna and Maglic, Dragana and Miković, Zeljko and Spasojević, Ivan", year = "2020", abstract = "Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.", publisher = "Public Library Science, San Francisco", journal = "PLoS One", title = "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias", number = "6", volume = "15", doi = "10.1371/journal.pone.0234253" }
Bogdanović Pristov, J., Opačić, M., Bajčetić, M., Mandic, V., Maglic, D., Miković, Z.,& Spasojević, I.. (2020). Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One Public Library Science, San Francisco., 15(6). https://doi.org/10.1371/journal.pone.0234253
Bogdanović Pristov J, Opačić M, Bajčetić M, Mandic V, Maglic D, Miković Z, Spasojević I. Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One. 2020;15(6). doi:10.1371/journal.pone.0234253 .
Bogdanović Pristov, Jelena, Opačić, Miloš, Bajčetić, Milica, Mandic, Vesna, Maglic, Dragana, Miković, Zeljko, Spasojević, Ivan, "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias" in PLoS One, 15, no. 6 (2020), https://doi.org/10.1371/journal.pone.0234253 . .