Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms
2020
Autori
Blagotinsek, Cokan, KajaMavri, Masa
Rutland, Catrin Sian
Glisic, Sanja
Sencanski, Milan
Vrecl, Milka
Kubale, Valentina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The type 2 dopamine receptor D-2 (D-2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D-2S-R) and long (D-2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D-2L-R. These isoforms differ in their intracellular localization and trafficking functionality, as D-2L-R possesses a larger intracellular pool, mostly in the endoplasmic reticulum (ER). This review focuses on the evolutionarily conserved motifs in the ICL3 of the D-2-R and proteins interacting with the ICL3 of both isoforms, specifically with the 29 AA insert. These motifs might be involved in D-2-R exit from the ER and have an impact on cell-surface and intracellular localization and, therefore, also play a role in the function of dopamine receptor signaling, ligand binding and possible homo/heterodimerization. Our recent bioinformatic data on potential new interaction partners for the ICL3 of D-2-Rs are also presented. Both are high...ly relevant, and have clinical impacts on the pathophysiology of several diseases such as Parkinson's disease, schizophrenia, Tourette's syndrome, Huntington's disease, manic depression, and others, as they are connected to a variety of essential motifs and differences in communication with interaction partners.
Ključne reči:
retention motifs / intracellular trafficking / interacting partners / ICL3 / endoplasmic reticulum / D-2 dopamine receptorIzvor:
Biomolecules, 2020, 10, 10Izdavač:
- MDPI, Basel
Finansiranje / projekti:
- Slovenian Research Agency ProgrammeSlovenian Research Agency - Slovenia [P4-0053]
- Slovenian-Serbian bilateral project [BI-RS/20-21-045]
- Slovenian Research AgencySlovenian Research Agency - Slovenia
- Primena EIIP/ISM bioinformatičke platforme u otkrivanju novih terapeutskih targeta i potencijalnih terapeutskih molekula (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.3390/biom10101355
ISSN: 2218-273X
PubMed: 32977535
WoS: 000584591400001
Scopus: 2-s2.0-85091388778
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Blagotinsek, Cokan, Kaja AU - Mavri, Masa AU - Rutland, Catrin Sian AU - Glisic, Sanja AU - Sencanski, Milan AU - Vrecl, Milka AU - Kubale, Valentina PY - 2020 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1301 AB - The type 2 dopamine receptor D-2 (D-2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D-2S-R) and long (D-2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D-2L-R. These isoforms differ in their intracellular localization and trafficking functionality, as D-2L-R possesses a larger intracellular pool, mostly in the endoplasmic reticulum (ER). This review focuses on the evolutionarily conserved motifs in the ICL3 of the D-2-R and proteins interacting with the ICL3 of both isoforms, specifically with the 29 AA insert. These motifs might be involved in D-2-R exit from the ER and have an impact on cell-surface and intracellular localization and, therefore, also play a role in the function of dopamine receptor signaling, ligand binding and possible homo/heterodimerization. Our recent bioinformatic data on potential new interaction partners for the ICL3 of D-2-Rs are also presented. Both are highly relevant, and have clinical impacts on the pathophysiology of several diseases such as Parkinson's disease, schizophrenia, Tourette's syndrome, Huntington's disease, manic depression, and others, as they are connected to a variety of essential motifs and differences in communication with interaction partners. PB - MDPI, Basel T2 - Biomolecules T1 - Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms IS - 10 VL - 10 DO - 10.3390/biom10101355 ER -
@article{ author = "Blagotinsek, Cokan, Kaja and Mavri, Masa and Rutland, Catrin Sian and Glisic, Sanja and Sencanski, Milan and Vrecl, Milka and Kubale, Valentina", year = "2020", abstract = "The type 2 dopamine receptor D-2 (D-2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D-2S-R) and long (D-2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D-2L-R. These isoforms differ in their intracellular localization and trafficking functionality, as D-2L-R possesses a larger intracellular pool, mostly in the endoplasmic reticulum (ER). This review focuses on the evolutionarily conserved motifs in the ICL3 of the D-2-R and proteins interacting with the ICL3 of both isoforms, specifically with the 29 AA insert. These motifs might be involved in D-2-R exit from the ER and have an impact on cell-surface and intracellular localization and, therefore, also play a role in the function of dopamine receptor signaling, ligand binding and possible homo/heterodimerization. Our recent bioinformatic data on potential new interaction partners for the ICL3 of D-2-Rs are also presented. Both are highly relevant, and have clinical impacts on the pathophysiology of several diseases such as Parkinson's disease, schizophrenia, Tourette's syndrome, Huntington's disease, manic depression, and others, as they are connected to a variety of essential motifs and differences in communication with interaction partners.", publisher = "MDPI, Basel", journal = "Biomolecules", title = "Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms", number = "10", volume = "10", doi = "10.3390/biom10101355" }
Blagotinsek, C. K., Mavri, M., Rutland, C. S., Glisic, S., Sencanski, M., Vrecl, M.,& Kubale, V.. (2020). Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms. in Biomolecules MDPI, Basel., 10(10). https://doi.org/10.3390/biom10101355
Blagotinsek CK, Mavri M, Rutland CS, Glisic S, Sencanski M, Vrecl M, Kubale V. Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms. in Biomolecules. 2020;10(10). doi:10.3390/biom10101355 .
Blagotinsek, Cokan, Kaja, Mavri, Masa, Rutland, Catrin Sian, Glisic, Sanja, Sencanski, Milan, Vrecl, Milka, Kubale, Valentina, "Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms" in Biomolecules, 10, no. 10 (2020), https://doi.org/10.3390/biom10101355 . .