dc.creator | Kolarević, Stoimir | |
dc.creator | Milovanović, Dragana | |
dc.creator | Kracun-Kolarević, Margareta | |
dc.creator | Kostić-Vuković, Jovana | |
dc.creator | Sunjog, Karolina | |
dc.creator | Martinović, Rajko | |
dc.creator | Đorđević Aleksić, Jelena | |
dc.creator | Novaković, Irena | |
dc.creator | Sladic, Dusan | |
dc.creator | Vukovic-Gacic, Branka | |
dc.date.accessioned | 2022-04-05T15:23:27Z | |
dc.date.available | 2022-04-05T15:23:27Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0148-0545 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1274 | |
dc.description.abstract | In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3 '-methoxyavarone, 4 '-(methylamino)avarone and 3 '-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3 '-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3 '-methoxyavarone and 3 '-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.rights | restrictedAccess | |
dc.source | Drug and Chemical Toxicology | |
dc.subject | SOS/umuC | en |
dc.subject | mutagenicity | en |
dc.subject | genotoxicity | en |
dc.subject | comet assay | en |
dc.subject | avarone | en |
dc.subject | Avarol | en |
dc.title | Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 139 | |
dc.citation.issue | 2 | |
dc.citation.other | 42(2): 130-139 | |
dc.citation.rank | M22 | |
dc.citation.spage | 130 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.1080/01480545.2017.1413108 | |
dc.identifier.pmid | 29299944 | |
dc.identifier.scopus | 2-s2.0-85041102861 | |
dc.identifier.wos | 000459818600003 | |
dc.type.version | publishedVersion | |