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dc.creatorSpasojević, Ivan
dc.creatorZakrzewska, Joanna
dc.creatorBačić, Goran
dc.date.accessioned2022-04-05T14:06:20Z
dc.date.available2022-04-05T14:06:20Z
dc.date.issued2005
dc.identifier.issn0077-8923
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/124
dc.description.abstractAntineoplastic drug 5-fluorouracil (5-FU) frequently shows cardiotoxic effects, the mechanism of which has not yet been elucidated. The objective of the present study was to explore effects of 5-FU on metabolism of ATP, 2,3-BPG, and oxygen in erythrocytes and to relate these to the phenomenon of 5-FU cardiotoxicity. We determined that 5-FU induced rapid increase in 02 consumption, which led to drastic changes in the metabolism of phosphate compounds in erythrocytes. Decrease in pO(2) provoked increase in production of 2,3-BPG and subsequent deoxygenation of oxyHb to deoxyHb. However, the most important effect of 5-FU on erythrocytes is severe decrease in the level of ATP. This could lead to a number of irreversible changes in erythrocyte structure and functioning, such as echinocytosis, increase in membrane fluidity, and non-functioning of membrane ion pumps. All these changes affect normal functioning of erythrocytes, leading to difficulties in oxygen transport and insufficient supply of oxygen to the heart, and pointing to the importance of studying the effects of antineoplastic drugs on intracellular metabolism of erythrocytes.en
dc.publisherNew York Acad Sciences, New York
dc.rightsrestrictedAccess
dc.sourceBiophysics From Molecules to Brain: in Memory of Radoslav K. Andjus
dc.subjectP-31 NMR spectroscopyen
dc.subjectoxygenen
dc.subjecterythrocytesen
dc.subjectcardiotoxicityen
dc.subject5-FUen
dc.titleP-31 NMR spectroscopy and polarographic combined study of erythrocytes treated with 5-fluorouracil - Cardiotoxicity-related changes in ATP, 2,3-BPG, and O-2 metabolismen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage320
dc.citation.other1048: 311-320
dc.citation.rankM21
dc.citation.spage311
dc.citation.volume1048
dc.identifier.doi10.1196/annals.1342.028
dc.identifier.pmid16154943
dc.identifier.scopus2-s2.0-25144480370
dc.identifier.wos000233712300027
dc.type.versionpublishedVersion


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