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Biliverdin-copper complex at physiological pH
dc.creator | Dimitrijević, Milena | |
dc.creator | Bogdanović Pristov, Jelena | |
dc.creator | Žižić, Milan | |
dc.creator | Stanković, Dalibor M. | |
dc.creator | Bajuk-Bogdanović, Danica | |
dc.creator | Stanić, Marina | |
dc.creator | Spasic, Snežana | |
dc.creator | Hagen, Wilfred | |
dc.creator | Spasojević, Ivan | |
dc.date.accessioned | 2022-04-05T15:21:36Z | |
dc.date.available | 2022-04-05T15:21:36Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1246 | |
dc.description.abstract | Biliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, H-1 NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1:1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e(-). The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O-2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43010/RS// | |
dc.relation | COST Action FeSBioNet [CA15133] | |
dc.relation | Magbiovin project [621375] | |
dc.rights | restrictedAccess | |
dc.source | Dalton Transactions | |
dc.subject | biliverdin | |
dc.subject | copper | |
dc.subject | complex | |
dc.subject | physiological pH | |
dc.title | Biliverdin-copper complex at physiological pH | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 6070 | |
dc.citation.issue | 18 | |
dc.citation.other | 48(18): 6061-6070 | |
dc.citation.rank | M21 | |
dc.citation.spage | 6061 | |
dc.citation.volume | 48 | |
dc.identifier.doi | 10.1039/c8dt04724c | |
dc.identifier.pmid | 30734795 | |
dc.identifier.scopus | 2-s2.0-85065545631 | |
dc.identifier.wos | 000472449300020 | |
dc.type.version | publishedVersion |