Приказ основних података о документу

dc.creatorDraca, Dijana
dc.creatorMijatović, Sanja
dc.creatorKrajnović, Tamara
dc.creatorBogdanović Pristov, Jelena
dc.creatorDukic, Tatjana
dc.creatorKaluderović, Goran N.
dc.creatorWessjohann, Ludger A.
dc.creatorMaksimović-Ivanić, Danijela
dc.date.accessioned2022-04-05T15:20:24Z
dc.date.available2022-04-05T15:20:24Z
dc.date.issued2019
dc.identifier.issn0014-4827
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1228
dc.description.abstractSynthetic tubugis are equally potent but more stable than their natural forms. Their anticancer potential was estimated on a solid melanoma in vitro and in vivo. Tubugi-1 induced the apoptosis in B16 cells accompanied with strong intracellular production of reactive species, subsequently imposing glutathione and thiol group depletion. Paradoxically, membrane lipids were excluded from the cascade of intracellular oxidation, according to malondialdehyde decrease. Although morphologically apoptosis was typical, externalization of phosphatidylserine (PS) as an early apoptotic event was not detected. Even their exposition is pivotal for apoptotic cell eradication, primary macrophages successfully eliminated PS-deficient tubugi-1 induced apoptotic cells. The tumor volume in animals exposed to the drug in therapeutic mode was reduced in comparison to control as well as to paclitaxeltreated animals Importantly, macrophages isolated from tubugi-1 treated animals possessed conserved phagocytic activity and were functionally and phenotypically recognized as Ml. The cytotoxic effect of tubugi-1 is accomplished through its ability to polarize the macrophages toward Ml, probably by PS independent apoptotic cell engulfment. The unique potential of tubugi-1 to prime the innate immune response through the induction of a specific pattern of tumor cell apoptosis can be of extraordinary importance from fundamental and applicable aspects.en
dc.publisherElsevier Inc, San Diego
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationLeibniz Institute of Plant Biochemistry, Halle
dc.relationGerman Academic Exchange Service (DAAD)Deutscher Akademischer Austausch Dienst (DAAD)
dc.rightsrestrictedAccess
dc.sourceExperimental Cell Research
dc.subjectTubulysinen
dc.subjectPhosphatidylserineen
dc.subjectMacrophage polarizationen
dc.subjectCanceren
dc.subjectApoptosisen
dc.titleThe synthetic tubulysin derivative, tubugi-1, improves the innate immune response by macrophage polarization in addition to its direct cytotoxic effects in a murine melanoma modelen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage170
dc.citation.issue2
dc.citation.other380(2): 159-170
dc.citation.rankM22
dc.citation.spage159
dc.citation.volume380
dc.identifier.doi10.1016/j.yexcr.2019.04.028
dc.identifier.pmid31042500
dc.identifier.scopus2-s2.0-85065046067
dc.identifier.wos000469307600006
dc.type.versionpublishedVersion


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Приказ основних података о документу