Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .
TY - JOUR
AU - Pejin, Boris
AU - Glumac, Miodrag
PY - 2019
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1209
AB - Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .
PB - Taylor & Francis Ltd, Abingdon
T2 - Natural Product Research
T1 - New cytotoxic natural products from the mangrove biome: covering the period 2007-2015
EP - 1628
IS - 11
SP - 1624
VL - 33
DO - 10.1080/14786419.2018.1425854
ER -
@article{
author = "Pejin, Boris and Glumac, Miodrag",
year = "2019",
abstract = "Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015",
pages = "1628-1624",
number = "11",
volume = "33",
doi = "10.1080/14786419.2018.1425854"
}
Pejin, B.,& Glumac, M.. (2019). New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(11), 1624-1628.
https://doi.org/10.1080/14786419.2018.1425854
Pejin B, Glumac M. New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research. 2019;33(11):1624-1628.
doi:10.1080/14786419.2018.1425854 .
Pejin, Boris, Glumac, Miodrag, "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015" in Natural Product Research, 33, no. 11 (2019):1624-1628,
https://doi.org/10.1080/14786419.2018.1425854 . .
