The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone.... Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.
TY - JOUR
AU - Nakarada, Dura
AU - Pejin, Boris
AU - Dimic, Dusan
AU - Ivanovic-Sasic, Ana
AU - Mojović, Zorica
AU - Mojović, Miloš
PY - 2019
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1206
AB - The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.
PB - Springer, Dordrecht
T2 - Reaction Kinetics Mechanisms and Catalysis
T1 - Electrochemical and spectroscopic study of l-dopa interaction with avarol
EP - 229
IS - 1
SP - 219
VL - 127
DO - 10.1007/s11144-019-01575-z
ER -
@article{
author = "Nakarada, Dura and Pejin, Boris and Dimic, Dusan and Ivanovic-Sasic, Ana and Mojović, Zorica and Mojović, Miloš",
year = "2019",
abstract = "The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.",
publisher = "Springer, Dordrecht",
journal = "Reaction Kinetics Mechanisms and Catalysis",
title = "Electrochemical and spectroscopic study of l-dopa interaction with avarol",
pages = "229-219",
number = "1",
volume = "127",
doi = "10.1007/s11144-019-01575-z"
}
Nakarada, D., Pejin, B., Dimic, D., Ivanovic-Sasic, A., Mojović, Z.,& Mojović, M.. (2019). Electrochemical and spectroscopic study of l-dopa interaction with avarol. in Reaction Kinetics Mechanisms and Catalysis
Springer, Dordrecht., 127(1), 219-229.
https://doi.org/10.1007/s11144-019-01575-z
Nakarada D, Pejin B, Dimic D, Ivanovic-Sasic A, Mojović Z, Mojović M. Electrochemical and spectroscopic study of l-dopa interaction with avarol. in Reaction Kinetics Mechanisms and Catalysis. 2019;127(1):219-229.
doi:10.1007/s11144-019-01575-z .
Nakarada, Dura, Pejin, Boris, Dimic, Dusan, Ivanovic-Sasic, Ana, Mojović, Zorica, Mojović, Miloš, "Electrochemical and spectroscopic study of l-dopa interaction with avarol" in Reaction Kinetics Mechanisms and Catalysis, 127, no. 1 (2019):219-229,
https://doi.org/10.1007/s11144-019-01575-z . .
