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Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
dc.creator | Karaman, Maja | |
dc.creator | Janjusević, Ljiljana | |
dc.creator | Jakovljević, Dragica | |
dc.creator | Sibul, Filip | |
dc.creator | Pejin, Boris | |
dc.date.accessioned | 2022-04-05T15:18:30Z | |
dc.date.available | 2022-04-05T15:18:30Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1200 | |
dc.description.abstract | This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | polar extract | en |
dc.subject | Mushrooms | en |
dc.subject | biological activity | en |
dc.subject | Amanitaceae | en |
dc.title | Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1526 | |
dc.citation.issue | 10 | |
dc.citation.other | 33(10): 1522-1526 | |
dc.citation.rank | M22 | |
dc.citation.spage | 1522 | |
dc.citation.volume | 33 | |
dc.identifier.doi | 10.1080/14786419.2017.1422183 | |
dc.identifier.pmid | 29295625 | |
dc.identifier.scopus | 2-s2.0-85039854192 | |
dc.identifier.wos | 000469243700024 | |
dc.type.version | publishedVersion |
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