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Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract

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Authors
Karaman, Maja
Janjusević, Ljiljana
Jakovljević, Dragica
Sibul, Filip
Pejin, Boris
Article (Published version)
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Abstract
This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natur...al origin successfully addressing both oxidative stress and lack of acetylcholine.

Keywords:
polar extract / Mushrooms / biological activity / Amanitaceae
Source:
Natural Product Research, 2019, 33, 10, 1522-1526
Publisher:
  • Taylor & Francis Ltd, Abingdon
Funding / projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Biosensing Technologies and Global System for Long-Term Research and Integrated Management of Ecosystems (RS-43002)
  • Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-43004)

DOI: 10.1080/14786419.2017.1422183

ISSN: 1478-6419

PubMed: 29295625

WoS: 000469243700024

Scopus: 2-s2.0-85039854192
[ Google Scholar ]
12
11
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/1200
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - JOUR
AU  - Karaman, Maja
AU  - Janjusević, Ljiljana
AU  - Jakovljević, Dragica
AU  - Sibul, Filip
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1200
AB  - This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
EP  - 1526
IS  - 10
SP  - 1522
VL  - 33
DO  - 10.1080/14786419.2017.1422183
ER  - 
@article{
author = "Karaman, Maja and Janjusević, Ljiljana and Jakovljević, Dragica and Sibul, Filip and Pejin, Boris",
year = "2019",
abstract = "This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract",
pages = "1526-1522",
number = "10",
volume = "33",
doi = "10.1080/14786419.2017.1422183"
}
Karaman, M., Janjusević, L., Jakovljević, D., Sibul, F.,& Pejin, B.. (2019). Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(10), 1522-1526.
https://doi.org/10.1080/14786419.2017.1422183
Karaman M, Janjusević L, Jakovljević D, Sibul F, Pejin B. Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research. 2019;33(10):1522-1526.
doi:10.1080/14786419.2017.1422183 .
Karaman, Maja, Janjusević, Ljiljana, Jakovljević, Dragica, Sibul, Filip, Pejin, Boris, "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract" in Natural Product Research, 33, no. 10 (2019):1522-1526,
https://doi.org/10.1080/14786419.2017.1422183 . .

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