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The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells
dc.creator | Pejin, Boris | |
dc.creator | Tommonaro, Giuseppina | |
dc.creator | Glumac, Miodrag | |
dc.creator | Jakimov, Dimitar | |
dc.creator | Kojić, Vesna | |
dc.date.accessioned | 2022-04-05T15:18:06Z | |
dc.date.available | 2022-04-05T15:18:06Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1194 | |
dc.description.abstract | This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] . | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | the avarol scaffold | en |
dc.subject | Dysidea avara | en |
dc.subject | Brain tumours | en |
dc.title | The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 620 | |
dc.citation.issue | 5 | |
dc.citation.other | 32(5): 616-620 | |
dc.citation.rank | M22 | |
dc.citation.spage | 616 | |
dc.citation.volume | 32 | |
dc.identifier.doi | 10.1080/14786419.2017.1327959 | |
dc.identifier.pmid | 28504009 | |
dc.identifier.scopus | 2-s2.0-85019215056 | |
dc.identifier.wos | 000426941200021 | |
dc.type.version | publishedVersion |
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