dc.creator | Pejin, Boris | |
dc.creator | Iodice, Carmine | |
dc.creator | Bogdanović, Gordana | |
dc.creator | Kojić, Vesna | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2022-04-05T15:11:10Z | |
dc.date.available | 2022-04-05T15:11:10Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1878-5352 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1092 | |
dc.description.abstract | The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Arabian Journal of Chemistry | |
dc.subject | MTT growth inhibition assay | en |
dc.subject | Lobaria pulmonaria | en |
dc.subject | Human colon adenocarcinoma | en |
dc.subject | beta-Orcinol depsidone | en |
dc.title | Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | S1242 | |
dc.citation.other | 10: S1240-S1242 | |
dc.citation.rank | M22 | |
dc.citation.spage | S1240 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.1016/j.arabjc.2013.03.003 | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/70/1089.pdf | |
dc.identifier.scopus | 2-s2.0-84875689064 | |
dc.identifier.wos | 000399414100163 | |
dc.type.version | publishedVersion | |