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dc.creatorPejin, Boris
dc.creatorIodice, Carmine
dc.creatorBogdanović, Gordana
dc.creatorKojić, Vesna
dc.creatorTešević, Vele
dc.date.accessioned2022-04-05T15:11:10Z
dc.date.available2022-04-05T15:11:10Z
dc.date.issued2017
dc.identifier.issn1878-5352
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1092
dc.description.abstractThe growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArabian Journal of Chemistry
dc.subjectMTT growth inhibition assayen
dc.subjectLobaria pulmonariaen
dc.subjectHuman colon adenocarcinomaen
dc.subjectbeta-Orcinol depsidoneen
dc.titleStictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cellsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epageS1242
dc.citation.other10: S1240-S1242
dc.citation.rankM22
dc.citation.spageS1240
dc.citation.volume10
dc.identifier.doi10.1016/j.arabjc.2013.03.003
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/70/1089.pdf
dc.identifier.scopus2-s2.0-84875689064
dc.identifier.wos000399414100163
dc.type.versionpublishedVersion


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