Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells

Pejin, Boris; Iodice, Carmine; Bogdanović, Gordana; Kojić, Vesna; Tešević, Vele

doi:10.1016/j.arabjc.2013.03.003

2017

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Authors

Pejin, Boris

Iodice, Carmine
Bogdanović, Gordana

Kojić, Vesna

Tešević, Vele

Article (Published version)

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Abstract

The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs.

Keywords:

MTT growth inhibition assay / Lobaria pulmonaria / Human colon adenocarcinoma / beta-Orcinol depsidone

Source:
Arabian Journal of Chemistry, 2017, 10, S1240-S1242

Publisher:

Elsevier Science Bv, Amsterdam

Funding / projects:

DOI: 10.1016/j.arabjc.2013.03.003

ISSN: 1878-5352

WoS: 000399414100163

Scopus: 2-s2.0-84875689064

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TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna
AU  - Tešević, Vele
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1092
AB  - The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs.
PB  - Elsevier Science Bv, Amsterdam
T2  - Arabian Journal of Chemistry
T1  - Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells
EP  - S1242
SP  - S1240
VL  - 10
DO  - 10.1016/j.arabjc.2013.03.003
ER  -

@article{
author = "Pejin, Boris and Iodice, Carmine and Bogdanović, Gordana and Kojić, Vesna and Tešević, Vele",
year = "2017",
abstract = "The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Arabian Journal of Chemistry",
title = "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells",
pages = "S1242-S1240",
volume = "10",
doi = "10.1016/j.arabjc.2013.03.003"
}

Pejin, B., Iodice, C., Bogdanović, G., Kojić, V.,& Tešević, V.. (2017). Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry
Elsevier Science Bv, Amsterdam., 10, S1240-S1242.
https://doi.org/10.1016/j.arabjc.2013.03.003

Pejin B, Iodice C, Bogdanović G, Kojić V, Tešević V. Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry. 2017;10:S1240-S1242.
doi:10.1016/j.arabjc.2013.03.003 .

Pejin, Boris, Iodice, Carmine, Bogdanović, Gordana, Kojić, Vesna, Tešević, Vele, "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells" in Arabian Journal of Chemistry, 10 (2017):S1240-S1242,
https://doi.org/10.1016/j.arabjc.2013.03.003 . .