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The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

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2017
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Аутори
Janjusević, Ljiljana
Karaman, Maja
Sibul, Filip
Tommonaro, Giuseppina
Iodice, Carmine
Jakovljević, Dragica
Pejin, Boris
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually u...sed as drug-like compounds or food supplements in the treatment of Alzheimer's disease.

Кључне речи:
water extract / Trametes versicolor / anti (OH)-O-center dot activity / Alzheimer's disease / AChE inhibitory activity
Извор:
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 1, 355-362
Издавач:
  • Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
  • Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-172053)
  • Биолошки активни природни производи као потенцијални извори нових лекова и дијететских суплемената (RS-172058)

DOI: 10.1080/14756366.2016.1252759

ISSN: 1475-6366

PubMed: 28097907

WoS: 000392591100028

Scopus: 2-s2.0-85015591411
[ Google Scholar ]
51
37
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/1086
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Institut za multidisciplinarna istraživanja
TY  - JOUR
AU  - Janjusević, Ljiljana
AU  - Karaman, Maja
AU  - Sibul, Filip
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Jakovljević, Dragica
AU  - Pejin, Boris
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1086
AB  - This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
EP  - 362
IS  - 1
SP  - 355
VL  - 32
DO  - 10.1080/14756366.2016.1252759
ER  - 
@article{
author = "Janjusević, Ljiljana and Karaman, Maja and Sibul, Filip and Tommonaro, Giuseppina and Iodice, Carmine and Jakovljević, Dragica and Pejin, Boris",
year = "2017",
abstract = "This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents",
pages = "362-355",
number = "1",
volume = "32",
doi = "10.1080/14756366.2016.1252759"
}
Janjusević, L., Karaman, M., Sibul, F., Tommonaro, G., Iodice, C., Jakovljević, D.,& Pejin, B.. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 355-362.
https://doi.org/10.1080/14756366.2016.1252759
Janjusević L, Karaman M, Sibul F, Tommonaro G, Iodice C, Jakovljević D, Pejin B. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):355-362.
doi:10.1080/14756366.2016.1252759 .
Janjusević, Ljiljana, Karaman, Maja, Sibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris, "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):355-362,
https://doi.org/10.1080/14756366.2016.1252759 . .

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