The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

2017
Authors
Janjusević, Ljiljana
Karaman, Maja

Sibul, Filip

Tommonaro, Giuseppina

Iodice, Carmine
Jakovljević, Dragica

Pejin, Boris

Article (Published version)
Metadata
Show full item recordAbstract
This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually u...sed as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
Keywords:
water extract / Trametes versicolor / anti (OH)-O-center dot activity / Alzheimer's disease / AChE inhibitory activitySource:
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 1, 355-362Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
DOI: 10.1080/14756366.2016.1252759
ISSN: 1475-6366
PubMed: 28097907
WoS: 000392591100028
Scopus: 2-s2.0-85015591411
Collections
Institution/Community
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Janjusević, Ljiljana AU - Karaman, Maja AU - Sibul, Filip AU - Tommonaro, Giuseppina AU - Iodice, Carmine AU - Jakovljević, Dragica AU - Pejin, Boris PY - 2017 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1086 AB - This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease. PB - Taylor & Francis Ltd, Abingdon T2 - Journal of Enzyme Inhibition and Medicinal Chemistry T1 - The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents EP - 362 IS - 1 SP - 355 VL - 32 DO - 10.1080/14756366.2016.1252759 ER -
@article{ author = "Janjusević, Ljiljana and Karaman, Maja and Sibul, Filip and Tommonaro, Giuseppina and Iodice, Carmine and Jakovljević, Dragica and Pejin, Boris", year = "2017", abstract = "This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Journal of Enzyme Inhibition and Medicinal Chemistry", title = "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents", pages = "362-355", number = "1", volume = "32", doi = "10.1080/14756366.2016.1252759" }
Janjusević, L., Karaman, M., Sibul, F., Tommonaro, G., Iodice, C., Jakovljević, D.,& Pejin, B.. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry Taylor & Francis Ltd, Abingdon., 32(1), 355-362. https://doi.org/10.1080/14756366.2016.1252759
Janjusević L, Karaman M, Sibul F, Tommonaro G, Iodice C, Jakovljević D, Pejin B. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):355-362. doi:10.1080/14756366.2016.1252759 .
Janjusević, Ljiljana, Karaman, Maja, Sibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris, "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):355-362, https://doi.org/10.1080/14756366.2016.1252759 . .