TY  - JOUR
AU  - Blagotinsek, Cokan, Kaja
AU  - Mavri, Masa
AU  - Rutland, Catrin Sian
AU  - Glisic, Sanja
AU  - Sencanski, Milan
AU  - Vrecl, Milka
AU  - Kubale, Valentina
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1301
AB  - The type 2 dopamine receptor D-2 (D-2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D-2S-R) and long (D-2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D-2L-R. These isoforms differ in their intracellular localization and trafficking functionality, as D-2L-R possesses a larger intracellular pool, mostly in the endoplasmic reticulum (ER). This review focuses on the evolutionarily conserved motifs in the ICL3 of the D-2-R and proteins interacting with the ICL3 of both isoforms, specifically with the 29 AA insert. These motifs might be involved in D-2-R exit from the ER and have an impact on cell-surface and intracellular localization and, therefore, also play a role in the function of dopamine receptor signaling, ligand binding and possible homo/heterodimerization. Our recent bioinformatic data on potential new interaction partners for the ICL3 of D-2-Rs are also presented. Both are highly relevant, and have clinical impacts on the pathophysiology of several diseases such as Parkinson's disease, schizophrenia, Tourette's syndrome, Huntington's disease, manic depression, and others, as they are connected to a variety of essential motifs and differences in communication with interaction partners.
PB  - MDPI, Basel
T2  - Biomolecules
T1  - Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms
IS  - 10
VL  - 10
DO  - 10.3390/biom10101355
ER  - 

@article{
author = "Blagotinsek, Cokan, Kaja and Mavri, Masa and Rutland, Catrin Sian and Glisic, Sanja and Sencanski, Milan and Vrecl, Milka and Kubale, Valentina",
year = "2020",
abstract = "The type 2 dopamine receptor D-2 (D-2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D-2S-R) and long (D-2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D-2L-R. These isoforms differ in their intracellular localization and trafficking functionality, as D-2L-R possesses a larger intracellular pool, mostly in the endoplasmic reticulum (ER). This review focuses on the evolutionarily conserved motifs in the ICL3 of the D-2-R and proteins interacting with the ICL3 of both isoforms, specifically with the 29 AA insert. These motifs might be involved in D-2-R exit from the ER and have an impact on cell-surface and intracellular localization and, therefore, also play a role in the function of dopamine receptor signaling, ligand binding and possible homo/heterodimerization. Our recent bioinformatic data on potential new interaction partners for the ICL3 of D-2-Rs are also presented. Both are highly relevant, and have clinical impacts on the pathophysiology of several diseases such as Parkinson's disease, schizophrenia, Tourette's syndrome, Huntington's disease, manic depression, and others, as they are connected to a variety of essential motifs and differences in communication with interaction partners.",
publisher = "MDPI, Basel",
journal = "Biomolecules",
title = "Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms",
number = "10",
volume = "10",
doi = "10.3390/biom10101355"
}

Blagotinsek, C. K., Mavri, M., Rutland, C. S., Glisic, S., Sencanski, M., Vrecl, M.,& Kubale, V.. (2020). Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms. in Biomolecules
MDPI, Basel., 10(10).
https://doi.org/10.3390/biom10101355

Blagotinsek CK, Mavri M, Rutland CS, Glisic S, Sencanski M, Vrecl M, Kubale V. Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms. in Biomolecules. 2020;10(10).
doi:10.3390/biom10101355 .

Blagotinsek, Cokan, Kaja, Mavri, Masa, Rutland, Catrin Sian, Glisic, Sanja, Sencanski, Milan, Vrecl, Milka, Kubale, Valentina, "Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D-2 Dopamine Receptor (D-2-R) Isoforms" in Biomolecules, 10, no. 10 (2020),
https://doi.org/10.3390/biom10101355 . .

TY  - JOUR
AU  - Petrović, Suzana M
AU  - Perusko, Davor B
AU  - Radovic-Bogdanović, I
AU  - Branković, Goran
AU  - Cekada, M
AU  - Gaković, Biljana M
AU  - Jaksic, M
AU  - Trtica, Milan S
AU  - Milosavljević, Momir S
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/532
AB  - In this work we studied the influence of laser radiation on the composition, structure and morphology of WTi thin films deposited on n-type (100) silicon wafers. The films were deposited by d.c. sputtering from a 70:30 at% W-Ti target, using Ar ions, to a thickness of similar to 190 nm. Irradiation was performed with a pulsed Nd:YAG laser operating at 1064 nm, whereas the pulse duration was 150 ps. Laser fluences of 3.2 and 5.9 J/cm(2) were found to be sufficient for modification of the WTi/silicon target system. The results show: (i) ablation of WTi thin film and a Si substrate in the central zone of spots, (ii) appearance of hydrodynamic features like resolidified material, (iii) partial ablation of the WTi thin film at the periphery and (iv) appearance of thin film cracks at the far periphery. On the non-ablated areas, the laser modification induced changes in composition, such as inter-mixing of components at the WTi/Si interface with formation of silicides in both metals. Surface oxidation was the dominant process in the ablated areas, which is demonstrated by the presence of a SiO2 phase.
PB  - Korean Inst Metals Materials, Seoul
T2  - Metals and Materials International
T1  - Evaluation of the composition and morphology of a WTi/Si system processed by a picosecond laser
EP  - 463
IS  - 3
SP  - 457
VL  - 18
DO  - 10.1007/s12540-012-3012-4
ER  - 

@article{
author = "Petrović, Suzana M and Perusko, Davor B and Radovic-Bogdanović, I and Branković, Goran and Cekada, M and Gaković, Biljana M and Jaksic, M and Trtica, Milan S and Milosavljević, Momir S",
year = "2012",
abstract = "In this work we studied the influence of laser radiation on the composition, structure and morphology of WTi thin films deposited on n-type (100) silicon wafers. The films were deposited by d.c. sputtering from a 70:30 at% W-Ti target, using Ar ions, to a thickness of similar to 190 nm. Irradiation was performed with a pulsed Nd:YAG laser operating at 1064 nm, whereas the pulse duration was 150 ps. Laser fluences of 3.2 and 5.9 J/cm(2) were found to be sufficient for modification of the WTi/silicon target system. The results show: (i) ablation of WTi thin film and a Si substrate in the central zone of spots, (ii) appearance of hydrodynamic features like resolidified material, (iii) partial ablation of the WTi thin film at the periphery and (iv) appearance of thin film cracks at the far periphery. On the non-ablated areas, the laser modification induced changes in composition, such as inter-mixing of components at the WTi/Si interface with formation of silicides in both metals. Surface oxidation was the dominant process in the ablated areas, which is demonstrated by the presence of a SiO2 phase.",
publisher = "Korean Inst Metals Materials, Seoul",
journal = "Metals and Materials International",
title = "Evaluation of the composition and morphology of a WTi/Si system processed by a picosecond laser",
pages = "463-457",
number = "3",
volume = "18",
doi = "10.1007/s12540-012-3012-4"
}

Petrović, S. M., Perusko, D. B., Radovic-Bogdanović, I., Branković, G., Cekada, M., Gaković, B. M., Jaksic, M., Trtica, M. S.,& Milosavljević, M. S.. (2012). Evaluation of the composition and morphology of a WTi/Si system processed by a picosecond laser. in Metals and Materials International
Korean Inst Metals Materials, Seoul., 18(3), 457-463.
https://doi.org/10.1007/s12540-012-3012-4

Petrović SM, Perusko DB, Radovic-Bogdanović I, Branković G, Cekada M, Gaković BM, Jaksic M, Trtica MS, Milosavljević MS. Evaluation of the composition and morphology of a WTi/Si system processed by a picosecond laser. in Metals and Materials International. 2012;18(3):457-463.
doi:10.1007/s12540-012-3012-4 .

Petrović, Suzana M, Perusko, Davor B, Radovic-Bogdanović, I, Branković, Goran, Cekada, M, Gaković, Biljana M, Jaksic, M, Trtica, Milan S, Milosavljević, Momir S, "Evaluation of the composition and morphology of a WTi/Si system processed by a picosecond laser" in Metals and Materials International, 18, no. 3 (2012):457-463,
https://doi.org/10.1007/s12540-012-3012-4 . .