TY  - JOUR
AU  - Martinović, Rajko
AU  - Kolarević, Stoimir
AU  - Kracun-Kolarević, Margareta
AU  - Kostić-Vuković, Jovana
AU  - Jokanović, Sandra
AU  - Gačić, Zoran
AU  - Joksimović, Danijela
AU  - Durović, Mirko
AU  - Kljajic, Zoran
AU  - Vukovic-Gacic, Branka
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1009
AB  - This study gives an insight in sensitivity of heart rate (Hr) of Mytilus galloprovincialis as a physiological biomarker. Impact of tributyltin chloride (TBT-Cl) on Hr was studied in parallel with evaluation of mutagenic, genotoxic and cytotoxic potential of TBT-Cl (10,100 and 1000 mu g/L) within 96 h treatment in static conditions. Mutagenic potential was assessed by SOS/umuC assay while genotoxicity was assessed in haemocytes of M. galloprovincialis by using the comet assay and the micronucleus test. Benzo(a)pyrene (B(a)P) was used as a positive control. Hr variations detected in TBT-Cl treatments can be linked to data obtained in the genotoxicological assays indicating that Hr can be considered and used as a reliable physiological biomarker for detecting the presence of organotin compounds. However despite the observed genotoxic potential of B(a)P, a noteworthy Hr response was not observed which further questions the potential of Hr in the detection of different types of pollutants.
PB  - Elsevier Science Bv, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride
EP  - 174
SP  - 165
VL  - 47
DO  - 10.1016/j.etap.2016.09.019
ER  - 

@article{
author = "Martinović, Rajko and Kolarević, Stoimir and Kracun-Kolarević, Margareta and Kostić-Vuković, Jovana and Jokanović, Sandra and Gačić, Zoran and Joksimović, Danijela and Durović, Mirko and Kljajic, Zoran and Vukovic-Gacic, Branka",
year = "2016",
abstract = "This study gives an insight in sensitivity of heart rate (Hr) of Mytilus galloprovincialis as a physiological biomarker. Impact of tributyltin chloride (TBT-Cl) on Hr was studied in parallel with evaluation of mutagenic, genotoxic and cytotoxic potential of TBT-Cl (10,100 and 1000 mu g/L) within 96 h treatment in static conditions. Mutagenic potential was assessed by SOS/umuC assay while genotoxicity was assessed in haemocytes of M. galloprovincialis by using the comet assay and the micronucleus test. Benzo(a)pyrene (B(a)P) was used as a positive control. Hr variations detected in TBT-Cl treatments can be linked to data obtained in the genotoxicological assays indicating that Hr can be considered and used as a reliable physiological biomarker for detecting the presence of organotin compounds. However despite the observed genotoxic potential of B(a)P, a noteworthy Hr response was not observed which further questions the potential of Hr in the detection of different types of pollutants.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride",
pages = "174-165",
volume = "47",
doi = "10.1016/j.etap.2016.09.019"
}

Martinović, R., Kolarević, S., Kracun-Kolarević, M., Kostić-Vuković, J., Jokanović, S., Gačić, Z., Joksimović, D., Durović, M., Kljajic, Z.,& Vukovic-Gacic, B.. (2016). Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride. in Environmental Toxicology and Pharmacology
Elsevier Science Bv, Amsterdam., 47, 165-174.
https://doi.org/10.1016/j.etap.2016.09.019

Martinović R, Kolarević S, Kracun-Kolarević M, Kostić-Vuković J, Jokanović S, Gačić Z, Joksimović D, Durović M, Kljajic Z, Vukovic-Gacic B. Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride. in Environmental Toxicology and Pharmacology. 2016;47:165-174.
doi:10.1016/j.etap.2016.09.019 .

Martinović, Rajko, Kolarević, Stoimir, Kracun-Kolarević, Margareta, Kostić-Vuković, Jovana, Jokanović, Sandra, Gačić, Zoran, Joksimović, Danijela, Durović, Mirko, Kljajic, Zoran, Vukovic-Gacic, Branka, "Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride" in Environmental Toxicology and Pharmacology, 47 (2016):165-174,
https://doi.org/10.1016/j.etap.2016.09.019 . .