TY  - JOUR
AU  - Štrbac, Filip
AU  - Bosco, Antonio
AU  - Maurelli, Maria Paola
AU  - Ratajac, Radomir
AU  - Stojanović, Dragica
AU  - Simin, Nataša
AU  - Orcic, Dejan
AU  - Pusic, Ivan
AU  - Krnjajić, Slobodan
AU  - Sotiraki, Smaragda
AU  - Saralli, Giorgio
AU  - Cringoli, Giuseppe
AU  - Rinaldi, Laura
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1548
AB  - Herbal products such as essential oils may play a promising role in the treatment of infections caused by gastrointestinal nematodes (GINs). The aim of this study was to evaluate the in vitro potential of 11 essential oils (EOs) and one binary combination of isolated EO compounds, as well as the in vivo anthelmintic efficacy of two EO formulations. Four GIN genera were identified in the coproculture examination: Haemonchus, Trichostrongylus, Teladorsagia and Chabertia. The in vitro egg hatch test (EHT) was performed at six different concentrations (50, 12.5, 3.125, 0.781, 0.195 and 0.049 mg/mL) for each EO, whereas in the in vivo faecal egg count reduction test (FECRT), each EO sample was diluted in sunflower oil and orally administrated at a dose of 100 mg/kg to the different group of animals. In the EHT, the EOs of Origanum vulgare, Foeniculum vulgare, Satureja montana, Satureja hortensis and two types of Thymus vulgaris were the most effective. The dominant compounds of these EOs were carvacrol, thymol, anethol, p-cymene and gamma-terpinene, indicating their importance for the anthelmintic activity. In the FECRT, both T. vulgaris EO type 1 and linalool:estragole combination show an anthelmintic potential with a mean effect on FECR of approximately 25%. The results suggest the possible role of tested EOs as anthelmintic agents in sheep farms, although further in vivo tests are needed.
PB  - MDPI, Basel
T2  - Veterinary Sciences
T1  - Anthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studies
IS  - 2
VL  - 9
DO  - 10.3390/vetsci9020093
ER  - 

@article{
author = "Štrbac, Filip and Bosco, Antonio and Maurelli, Maria Paola and Ratajac, Radomir and Stojanović, Dragica and Simin, Nataša and Orcic, Dejan and Pusic, Ivan and Krnjajić, Slobodan and Sotiraki, Smaragda and Saralli, Giorgio and Cringoli, Giuseppe and Rinaldi, Laura",
year = "2022",
abstract = "Herbal products such as essential oils may play a promising role in the treatment of infections caused by gastrointestinal nematodes (GINs). The aim of this study was to evaluate the in vitro potential of 11 essential oils (EOs) and one binary combination of isolated EO compounds, as well as the in vivo anthelmintic efficacy of two EO formulations. Four GIN genera were identified in the coproculture examination: Haemonchus, Trichostrongylus, Teladorsagia and Chabertia. The in vitro egg hatch test (EHT) was performed at six different concentrations (50, 12.5, 3.125, 0.781, 0.195 and 0.049 mg/mL) for each EO, whereas in the in vivo faecal egg count reduction test (FECRT), each EO sample was diluted in sunflower oil and orally administrated at a dose of 100 mg/kg to the different group of animals. In the EHT, the EOs of Origanum vulgare, Foeniculum vulgare, Satureja montana, Satureja hortensis and two types of Thymus vulgaris were the most effective. The dominant compounds of these EOs were carvacrol, thymol, anethol, p-cymene and gamma-terpinene, indicating their importance for the anthelmintic activity. In the FECRT, both T. vulgaris EO type 1 and linalool:estragole combination show an anthelmintic potential with a mean effect on FECR of approximately 25%. The results suggest the possible role of tested EOs as anthelmintic agents in sheep farms, although further in vivo tests are needed.",
publisher = "MDPI, Basel",
journal = "Veterinary Sciences",
title = "Anthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studies",
number = "2",
volume = "9",
doi = "10.3390/vetsci9020093"
}

Štrbac, F., Bosco, A., Maurelli, M. P., Ratajac, R., Stojanović, D., Simin, N., Orcic, D., Pusic, I., Krnjajić, S., Sotiraki, S., Saralli, G., Cringoli, G.,& Rinaldi, L.. (2022). Anthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studies. in Veterinary Sciences
MDPI, Basel., 9(2).
https://doi.org/10.3390/vetsci9020093

Štrbac F, Bosco A, Maurelli MP, Ratajac R, Stojanović D, Simin N, Orcic D, Pusic I, Krnjajić S, Sotiraki S, Saralli G, Cringoli G, Rinaldi L. Anthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studies. in Veterinary Sciences. 2022;9(2).
doi:10.3390/vetsci9020093 .

Štrbac, Filip, Bosco, Antonio, Maurelli, Maria Paola, Ratajac, Radomir, Stojanović, Dragica, Simin, Nataša, Orcic, Dejan, Pusic, Ivan, Krnjajić, Slobodan, Sotiraki, Smaragda, Saralli, Giorgio, Cringoli, Giuseppe, Rinaldi, Laura, "Anthelmintic Properties of Essential Oils to Control Gastrointestinal Nematodes in Sheep-In Vitro and In Vivo Studies" in Veterinary Sciences, 9, no. 2 (2022),
https://doi.org/10.3390/vetsci9020093 . .