Application of biomedical engineering for preclinical and clinical practice

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Application of biomedical engineering for preclinical and clinical practice (en)
Примена биомедицинског инжењеринга у претклиничкој и клиничкој пракси (sr)
Primena biomedicinskog inženjeringa u pretkliničkoj i kliničkoj praksi (sr_RS)
Authors

Publications

Semiconductor Gas Sensors: Materials, Technology, Design, and Application

Nikolić, Maria Vesna; Milovanović, Vladimir; Vasiljević, Zorka Z; Stamenković, Zoran

(MDPI, Basel, 2020)

TY  - JOUR
AU  - Nikolić, Maria Vesna
AU  - Milovanović, Vladimir
AU  - Vasiljević, Zorka Z
AU  - Stamenković, Zoran
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1374
AB  - This paper presents an overview of semiconductor materials used in gas sensors, their technology, design, and application. Semiconductor materials include metal oxides, conducting polymers, carbon nanotubes, and 2D materials. Metal oxides are most often the first choice due to their ease of fabrication, low cost, high sensitivity, and stability. Some of their disadvantages are low selectivity and high operating temperature. Conducting polymers have the advantage of a low operating temperature and can detect many organic vapors. They are flexible but affected by humidity. Carbon nanotubes are chemically and mechanically stable and are sensitive towards NO and NH3, but need dopants or modifications to sense other gases. Graphene, transition metal chalcogenides, boron nitride, transition metal carbides/nitrides, metal organic frameworks, and metal oxide nanosheets as 2D materials represent gas-sensing materials of the future, especially in medical devices, such as breath sensing. This overview covers the most used semiconducting materials in gas sensing, their synthesis methods and morphology, especially oxide nanostructures, heterostructures, and 2D materials, as well as sensor technology and design, application in advance electronic circuits and systems, and research challenges from the perspective of emerging technologies.
PB  - MDPI, Basel
T2  - Sensors
T1  - Semiconductor Gas Sensors: Materials, Technology, Design, and Application
IS  - 22
VL  - 20
DO  - 10.3390/s20226694
ER  - 
@article{
author = "Nikolić, Maria Vesna and Milovanović, Vladimir and Vasiljević, Zorka Z and Stamenković, Zoran",
year = "2020",
abstract = "This paper presents an overview of semiconductor materials used in gas sensors, their technology, design, and application. Semiconductor materials include metal oxides, conducting polymers, carbon nanotubes, and 2D materials. Metal oxides are most often the first choice due to their ease of fabrication, low cost, high sensitivity, and stability. Some of their disadvantages are low selectivity and high operating temperature. Conducting polymers have the advantage of a low operating temperature and can detect many organic vapors. They are flexible but affected by humidity. Carbon nanotubes are chemically and mechanically stable and are sensitive towards NO and NH3, but need dopants or modifications to sense other gases. Graphene, transition metal chalcogenides, boron nitride, transition metal carbides/nitrides, metal organic frameworks, and metal oxide nanosheets as 2D materials represent gas-sensing materials of the future, especially in medical devices, such as breath sensing. This overview covers the most used semiconducting materials in gas sensing, their synthesis methods and morphology, especially oxide nanostructures, heterostructures, and 2D materials, as well as sensor technology and design, application in advance electronic circuits and systems, and research challenges from the perspective of emerging technologies.",
publisher = "MDPI, Basel",
journal = "Sensors",
title = "Semiconductor Gas Sensors: Materials, Technology, Design, and Application",
number = "22",
volume = "20",
doi = "10.3390/s20226694"
}
Nikolić, M. V., Milovanović, V., Vasiljević, Z. Z.,& Stamenković, Z.. (2020). Semiconductor Gas Sensors: Materials, Technology, Design, and Application. in Sensors
MDPI, Basel., 20(22).
https://doi.org/10.3390/s20226694
Nikolić MV, Milovanović V, Vasiljević ZZ, Stamenković Z. Semiconductor Gas Sensors: Materials, Technology, Design, and Application. in Sensors. 2020;20(22).
doi:10.3390/s20226694 .
Nikolić, Maria Vesna, Milovanović, Vladimir, Vasiljević, Zorka Z, Stamenković, Zoran, "Semiconductor Gas Sensors: Materials, Technology, Design, and Application" in Sensors, 20, no. 22 (2020),
https://doi.org/10.3390/s20226694 . .
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OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL

Pantić, Nevena; Popović, Nikolina; Prokopijević, Miloš; Spasojević, Dragica; Prodanović, Radivoje; Đikanović, Daniela; Prodanović, Olivera

(University of Belgrade, Technical Faculty in Bor, 2019)

TY  - CONF
AU  - Pantić, Nevena
AU  - Popović, Nikolina
AU  - Prokopijević, Miloš
AU  - Spasojević, Dragica
AU  - Prodanović, Radivoje
AU  - Đikanović, Daniela
AU  - Prodanović, Olivera
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1656
AB  - Phenolic compounds are one of the most common pollutants in aqueous systems, so their removal
from water is of major interest. Among biocatalysts used for phenol removal, horseradish peroxidase
is the most investigated for this purpose. Enzyme inactivation is a major problem which could be
successfully overcome by immobilization of the enzyme onto different polymers. Tyramine-alginate
micro-beads were tested for the immobilization of horseradish peroxidase. Different concentrations of
tyramine-alginate were used and their influence on specific activity of the enzyme was tested.
Increasing concentration of oxidized alginate results in increase of specific activity. Immobilized HRP
was tested for phenol removal in a batch reactor. Presented results were obtained with HRP
immobilized within 10 mol% tyramine-alginate micro-beads. These biocatalysts can be used up to
three cycles.
PB  - University of Belgrade, Technical Faculty in Bor
C3  - 27th International Conference Ecological Truth and Environmental Research
T1  - OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL
SP  - 220-223
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1656
ER  - 
@conference{
author = "Pantić, Nevena and Popović, Nikolina and Prokopijević, Miloš and Spasojević, Dragica and Prodanović, Radivoje and Đikanović, Daniela and Prodanović, Olivera",
year = "2019",
abstract = "Phenolic compounds are one of the most common pollutants in aqueous systems, so their removal
from water is of major interest. Among biocatalysts used for phenol removal, horseradish peroxidase
is the most investigated for this purpose. Enzyme inactivation is a major problem which could be
successfully overcome by immobilization of the enzyme onto different polymers. Tyramine-alginate
micro-beads were tested for the immobilization of horseradish peroxidase. Different concentrations of
tyramine-alginate were used and their influence on specific activity of the enzyme was tested.
Increasing concentration of oxidized alginate results in increase of specific activity. Immobilized HRP
was tested for phenol removal in a batch reactor. Presented results were obtained with HRP
immobilized within 10 mol% tyramine-alginate micro-beads. These biocatalysts can be used up to
three cycles.",
publisher = "University of Belgrade, Technical Faculty in Bor",
journal = "27th International Conference Ecological Truth and Environmental Research",
title = "OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL",
pages = "220-223",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1656"
}
Pantić, N., Popović, N., Prokopijević, M., Spasojević, D., Prodanović, R., Đikanović, D.,& Prodanović, O.. (2019). OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL. in 27th International Conference Ecological Truth and Environmental Research
University of Belgrade, Technical Faculty in Bor., 220-223.
https://hdl.handle.net/21.15107/rcub_rimsi_1656
Pantić N, Popović N, Prokopijević M, Spasojević D, Prodanović R, Đikanović D, Prodanović O. OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL. in 27th International Conference Ecological Truth and Environmental Research. 2019;:220-223.
https://hdl.handle.net/21.15107/rcub_rimsi_1656 .
Pantić, Nevena, Popović, Nikolina, Prokopijević, Miloš, Spasojević, Dragica, Prodanović, Radivoje, Đikanović, Daniela, Prodanović, Olivera, "OPTIMIZATION OF HORSERADISH PEROXIDASE ENCAPSULATION WITHIN TYRAMINE-ALGINATE FOR PHENOL REMOVAL" in 27th International Conference Ecological Truth and Environmental Research (2019):220-223,
https://hdl.handle.net/21.15107/rcub_rimsi_1656 .

The enzyme immobilization: Carriers and immobilization methods

Spasojević, Milica; Prodanović, Olivera; Pantić, Nevena; Popović, Nikolina; Balaž, Ana Marija; Prodanović, Radivoje

(Faculty of Technology Zvornik, 2019)

TY  - JOUR
AU  - Spasojević, Milica
AU  - Prodanović, Olivera
AU  - Pantić, Nevena
AU  - Popović, Nikolina
AU  - Balaž, Ana Marija
AU  - Prodanović, Radivoje
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1757
AB  - Strategies based on the enzyme application are increasingly replacing the conventional chemical procedures because of their efficiency, quicker performance and environmental protection. However, natural enzymes can rarely be used in industry since their beneficial features cannot endure the industrial conditions. Additional drawbacks of natural enzymes are their inhibition by reaction products and difficulty to be removed from the reaction mixture. The most promising technique to substantially improve the enzyme properties, such as activity, pH, thermal and organic-solvent stability, reusability and storage stability, in non-natural environments is by the enzyme immobilization. In this review different techniques used to immobilize enzymes to inert carriers were summarized. Different materials of both the organic and inorganic origin were used as carriers for the enzyme immobilization. A class of new materials where the enzyme performance was enhanced by combining different classical materials and shaping in specific forms was also summarized.
PB  - Faculty of Technology Zvornik
T2  - Journal of Engineering & Processing Management
T1  - The enzyme immobilization: Carriers and immobilization methods
EP  - 105
IS  - 2
SP  - 89
VL  - 11
DO  - 10.7251/jepm1902089s
ER  - 
@article{
author = "Spasojević, Milica and Prodanović, Olivera and Pantić, Nevena and Popović, Nikolina and Balaž, Ana Marija and Prodanović, Radivoje",
year = "2019",
abstract = "Strategies based on the enzyme application are increasingly replacing the conventional chemical procedures because of their efficiency, quicker performance and environmental protection. However, natural enzymes can rarely be used in industry since their beneficial features cannot endure the industrial conditions. Additional drawbacks of natural enzymes are their inhibition by reaction products and difficulty to be removed from the reaction mixture. The most promising technique to substantially improve the enzyme properties, such as activity, pH, thermal and organic-solvent stability, reusability and storage stability, in non-natural environments is by the enzyme immobilization. In this review different techniques used to immobilize enzymes to inert carriers were summarized. Different materials of both the organic and inorganic origin were used as carriers for the enzyme immobilization. A class of new materials where the enzyme performance was enhanced by combining different classical materials and shaping in specific forms was also summarized.",
publisher = "Faculty of Technology Zvornik",
journal = "Journal of Engineering & Processing Management",
title = "The enzyme immobilization: Carriers and immobilization methods",
pages = "105-89",
number = "2",
volume = "11",
doi = "10.7251/jepm1902089s"
}
Spasojević, M., Prodanović, O., Pantić, N., Popović, N., Balaž, A. M.,& Prodanović, R.. (2019). The enzyme immobilization: Carriers and immobilization methods. in Journal of Engineering & Processing Management
Faculty of Technology Zvornik., 11(2), 89-105.
https://doi.org/10.7251/jepm1902089s
Spasojević M, Prodanović O, Pantić N, Popović N, Balaž AM, Prodanović R. The enzyme immobilization: Carriers and immobilization methods. in Journal of Engineering & Processing Management. 2019;11(2):89-105.
doi:10.7251/jepm1902089s .
Spasojević, Milica, Prodanović, Olivera, Pantić, Nevena, Popović, Nikolina, Balaž, Ana Marija, Prodanović, Radivoje, "The enzyme immobilization: Carriers and immobilization methods" in Journal of Engineering & Processing Management, 11, no. 2 (2019):89-105,
https://doi.org/10.7251/jepm1902089s . .
13

The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis

Cukic, Milena; Oommen, J; Mutavdžić, Dragosav; Jorgovanović, Nikola D; Ljubisavljević, Milos R

(Springer, New York, 2013)

TY  - JOUR
AU  - Cukic, Milena
AU  - Oommen, J
AU  - Mutavdžić, Dragosav
AU  - Jorgovanović, Nikola D
AU  - Ljubisavljević, Milos R
PY  - 2013
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/697
AB  - The aim of this study was to examine whether single-pulse transcranial magnetic stimulation (spTMS) affects the pattern of corticospinal activity once voluntary drive has been restored after spTMS-induced EMG silence. We used fractal dimension (FD) to explore the 'complexity' of the electromyography (EMG) signal, and median frequency of the spectra (MDF) to examine changes in EMG spectral characteristics. FD and MDF of the raw EMG epochs immediately before were compared with those obtained from epochs after the EMG silence. Changes in FD and MDF after spTMS were examined with three levels of muscle contraction corresponding to weak (20-40 %), moderate (40-60 %) and strong (60-80 % of maximal voluntary contraction) and three intensities of stimulation set at 10, 20 and 30 % above the resting motor threshold. FD was calculated using the Higuchi fractal dimension algorithm. Finally, to discern the origin of FD changes between the CNS and muscle, we compared the effects of spTMS with the effects of peripheral nerve stimulation (PNS) on FD and MDF. The results show that spTMS induced significant decrease in both FD and MDF of EMG signal after stimulation. PNS did not have any significant effects on FD nor MDF. Changes in TMS intensity did not have any significant effect on FD or MDF after stimulation nor had the strength of muscle contraction. However, increase in contraction strength decreased FD before stimulation but only between weak and moderate contraction. The results suggest that the effects of spTMS on corticospinal activity, underlying voluntary motor output, outlast the TMS stimulus. It appears that the complexity of the EMG signal is reduced after spTMS, suggesting that TMS alters the dynamics of the ongoing corticospinal activity most likely temporarily synchronizing the neural network activity. Further studies are needed to confirm whether observed changes after TMS occur at the cortical level.
PB  - Springer, New York
T2  - Experimental Brain Research
T1  - The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis
EP  - 104
IS  - 1
SP  - 97
VL  - 228
DO  - 10.1007/s00221-013-3541-1
ER  - 
@article{
author = "Cukic, Milena and Oommen, J and Mutavdžić, Dragosav and Jorgovanović, Nikola D and Ljubisavljević, Milos R",
year = "2013",
abstract = "The aim of this study was to examine whether single-pulse transcranial magnetic stimulation (spTMS) affects the pattern of corticospinal activity once voluntary drive has been restored after spTMS-induced EMG silence. We used fractal dimension (FD) to explore the 'complexity' of the electromyography (EMG) signal, and median frequency of the spectra (MDF) to examine changes in EMG spectral characteristics. FD and MDF of the raw EMG epochs immediately before were compared with those obtained from epochs after the EMG silence. Changes in FD and MDF after spTMS were examined with three levels of muscle contraction corresponding to weak (20-40 %), moderate (40-60 %) and strong (60-80 % of maximal voluntary contraction) and three intensities of stimulation set at 10, 20 and 30 % above the resting motor threshold. FD was calculated using the Higuchi fractal dimension algorithm. Finally, to discern the origin of FD changes between the CNS and muscle, we compared the effects of spTMS with the effects of peripheral nerve stimulation (PNS) on FD and MDF. The results show that spTMS induced significant decrease in both FD and MDF of EMG signal after stimulation. PNS did not have any significant effects on FD nor MDF. Changes in TMS intensity did not have any significant effect on FD or MDF after stimulation nor had the strength of muscle contraction. However, increase in contraction strength decreased FD before stimulation but only between weak and moderate contraction. The results suggest that the effects of spTMS on corticospinal activity, underlying voluntary motor output, outlast the TMS stimulus. It appears that the complexity of the EMG signal is reduced after spTMS, suggesting that TMS alters the dynamics of the ongoing corticospinal activity most likely temporarily synchronizing the neural network activity. Further studies are needed to confirm whether observed changes after TMS occur at the cortical level.",
publisher = "Springer, New York",
journal = "Experimental Brain Research",
title = "The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis",
pages = "104-97",
number = "1",
volume = "228",
doi = "10.1007/s00221-013-3541-1"
}
Cukic, M., Oommen, J., Mutavdžić, D., Jorgovanović, N. D.,& Ljubisavljević, M. R.. (2013). The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis. in Experimental Brain Research
Springer, New York., 228(1), 97-104.
https://doi.org/10.1007/s00221-013-3541-1
Cukic M, Oommen J, Mutavdžić D, Jorgovanović ND, Ljubisavljević MR. The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis. in Experimental Brain Research. 2013;228(1):97-104.
doi:10.1007/s00221-013-3541-1 .
Cukic, Milena, Oommen, J, Mutavdžić, Dragosav, Jorgovanović, Nikola D, Ljubisavljević, Milos R, "The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis" in Experimental Brain Research, 228, no. 1 (2013):97-104,
https://doi.org/10.1007/s00221-013-3541-1 . .
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