TY  - JOUR
AU  - Kostic, Ivana
AU  - Ilic, Vesna
AU  - Bukara, Katarina M.
AU  - Mojsilovic, Slavko
AU  - Đurić, Zorka Z
AU  - Draskovic, Petra
AU  - Bugarski, Branko
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2540
AB  - Despite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitates the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of porcine erythrocytes, it indicated the differences in porcine erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected.
T2  - Hemijska industrija
T1  - Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery
VL  - 69
DO  - http://dx.doi.org/10.2298/HEMIND140124021K
ER  - 

@article{
author = "Kostic, Ivana and Ilic, Vesna and Bukara, Katarina M. and Mojsilovic, Slavko and Đurić, Zorka Z and Draskovic, Petra and Bugarski, Branko",
year = "2015",
abstract = "Despite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitates the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of porcine erythrocytes, it indicated the differences in porcine erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected.",
journal = "Hemijska industrija",
title = "Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery",
volume = "69",
doi = "http://dx.doi.org/10.2298/HEMIND140124021K"
}

Kostic, I., Ilic, V., Bukara, K. M., Mojsilovic, S., Đurić, Z. Z., Draskovic, P.,& Bugarski, B.. (2015). Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery. in Hemijska industrija, 69.
https://doi.org/http://dx.doi.org/10.2298/HEMIND140124021K

Kostic I, Ilic V, Bukara KM, Mojsilovic S, Đurić ZZ, Draskovic P, Bugarski B. Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery. in Hemijska industrija. 2015;69.
doi:http://dx.doi.org/10.2298/HEMIND140124021K .

Kostic, Ivana, Ilic, Vesna, Bukara, Katarina M., Mojsilovic, Slavko, Đurić, Zorka Z, Draskovic, Petra, Bugarski, Branko, "Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery" in Hemijska industrija, 69 (2015),
https://doi.org/http://dx.doi.org/10.2298/HEMIND140124021K . .