@inbook{
author = "Opačić, Miloš and Ristic, Aleksandar J and Savic, Danijela and Selih, Vid Simon and Zivin, Marko and Sokic, Dragoslav and Raičević, Savo and Bascarevic, Vladimir and Spasojević, Ivan",
year = "2017",
abstract = "Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human
focal epilepsies and perhaps the best-characterized disorder of this type 1
. Hippocampal
sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2
. The histopathologic hallmark of HS is segmental pyramidal cell loss,
which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss
is always associated with a severe pattern of astrogliosis 3
. Therewithal, disturbed
homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been
considered to play a major role in epileptogenesis in relation to its involvement in the
modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that
epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low
brain levels of copper and manganese have been reported in patients with Menkes disease
and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were
the first to conduct a case-control study of total concentration of metals in tissue of human
HS, and report lower concentrations of copper and manganese 10.",
publisher = "Biohemijsko društvo Srbije",
journal = "Biochemistry of Control in Life and Technology",
booktitle = "Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy",
pages = "181-179",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2938"
}