@conference{
author = "Bozic Cvijan, Bojana and Korać Jačić, Jelena and Stanković, Dalibor and Stanić, Marina and Popovic Bijelic, Ana and Bogdanović Pristov, Jelena and Spasojević, Ivan and Bajcetic, Milica",
year = "2019",
abstract = "Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or
coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological
pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry.
Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to
inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions
with BR. Cu1+ undergoes spontaneous oxidation by O2 resulting in hydrogen peroxide accumulation and
hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects
on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species
by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further
examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia
is needed.",
publisher = "Srpsko farmakološko društvo Beograd, Novi Sad",
journal = "14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation",
title = "Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper",
pages = "242-240",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2847"
}