TY  - JOUR
AU  - Stosic, Jelena
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Nikolic, Miroslav
AU  - Popov, Aleksandra D
AU  - Kataranovski, Dragan S
AU  - Kataranovski, Milena V
PY  - 2010
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/404
AB  - Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA) stimulation was noted in cells recovered from lungs of male rats. Rise in intracellular content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6 levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.
PB  - Chinese Center Disease Control & Prevention, Beijing
T2  - Biomedical and Environmental Sciences
T1  - Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats
EP  - 299
IS  - 4
SP  - 293
VL  - 23
DO  - 10.1016/S0895-3988(10)60066-9
ER  - 

@article{
author = "Stosic, Jelena and Mirkov, Ivana and Belij, Sandra and Nikolic, Miroslav and Popov, Aleksandra D and Kataranovski, Dragan S and Kataranovski, Milena V",
year = "2010",
abstract = "Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA) stimulation was noted in cells recovered from lungs of male rats. Rise in intracellular content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6 levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.",
publisher = "Chinese Center Disease Control & Prevention, Beijing",
journal = "Biomedical and Environmental Sciences",
title = "Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats",
pages = "299-293",
number = "4",
volume = "23",
doi = "10.1016/S0895-3988(10)60066-9"
}

Stosic, J., Mirkov, I., Belij, S., Nikolic, M., Popov, A. D., Kataranovski, D. S.,& Kataranovski, M. V.. (2010). Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats. in Biomedical and Environmental Sciences
Chinese Center Disease Control & Prevention, Beijing., 23(4), 293-299.
https://doi.org/10.1016/S0895-3988(10)60066-9

Stosic J, Mirkov I, Belij S, Nikolic M, Popov AD, Kataranovski DS, Kataranovski MV. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats. in Biomedical and Environmental Sciences. 2010;23(4):293-299.
doi:10.1016/S0895-3988(10)60066-9 .

Stosic, Jelena, Mirkov, Ivana, Belij, Sandra, Nikolic, Miroslav, Popov, Aleksandra D, Kataranovski, Dragan S, Kataranovski, Milena V, "Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats" in Biomedical and Environmental Sciences, 23, no. 4 (2010):293-299,
https://doi.org/10.1016/S0895-3988(10)60066-9 . .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Nikolic, Miroslav
AU  - Zolotarevski, Lidija
AU  - Ciric, Danica
AU  - Kataranovski, Dragan
PY  - 2009
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/342
AB  - Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal.
PB  - Elsevier Science Bv, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Lungs: Remote inflammatory target of systemic cadmium administration in rats
EP  - 231
IS  - 2
SP  - 225
VL  - 28
DO  - 10.1016/j.etap.2009.04.008
ER  - 

@article{
author = "Kataranovski, Milena and Mirkov, Ivana and Belij, Sandra and Nikolic, Miroslav and Zolotarevski, Lidija and Ciric, Danica and Kataranovski, Dragan",
year = "2009",
abstract = "Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Lungs: Remote inflammatory target of systemic cadmium administration in rats",
pages = "231-225",
number = "2",
volume = "28",
doi = "10.1016/j.etap.2009.04.008"
}

Kataranovski, M., Mirkov, I., Belij, S., Nikolic, M., Zolotarevski, L., Ciric, D.,& Kataranovski, D.. (2009). Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology
Elsevier Science Bv, Amsterdam., 28(2), 225-231.
https://doi.org/10.1016/j.etap.2009.04.008

Kataranovski M, Mirkov I, Belij S, Nikolic M, Zolotarevski L, Ciric D, Kataranovski D. Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology. 2009;28(2):225-231.
doi:10.1016/j.etap.2009.04.008 .

Kataranovski, Milena, Mirkov, Ivana, Belij, Sandra, Nikolic, Miroslav, Zolotarevski, Lidija, Ciric, Danica, Kataranovski, Dragan, "Lungs: Remote inflammatory target of systemic cadmium administration in rats" in Environmental Toxicology and Pharmacology, 28, no. 2 (2009):225-231,
https://doi.org/10.1016/j.etap.2009.04.008 . .