TY  - JOUR
AU  - Nakarada, Dura
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Mojović, Miloš
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1340
AB  - The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Liposome Research
T1  - Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol
EP  - 226
IS  - 3
SP  - 218
VL  - 30
DO  - 10.1080/08982104.2019.1625378
ER  - 

@article{
author = "Nakarada, Dura and Pejin, Boris and Tommonaro, Giuseppina and Mojović, Miloš",
year = "2020",
abstract = "The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Liposome Research",
title = "Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol",
pages = "226-218",
number = "3",
volume = "30",
doi = "10.1080/08982104.2019.1625378"
}

Nakarada, D., Pejin, B., Tommonaro, G.,& Mojović, M.. (2020). Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol. in Journal of Liposome Research
Taylor & Francis Ltd, Abingdon., 30(3), 218-226.
https://doi.org/10.1080/08982104.2019.1625378

Nakarada D, Pejin B, Tommonaro G, Mojović M. Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol. in Journal of Liposome Research. 2020;30(3):218-226.
doi:10.1080/08982104.2019.1625378 .

Nakarada, Dura, Pejin, Boris, Tommonaro, Giuseppina, Mojović, Miloš, "Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol" in Journal of Liposome Research, 30, no. 3 (2020):218-226,
https://doi.org/10.1080/08982104.2019.1625378 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Glumac, Miodrag
AU  - Jakimov, Dimitar
AU  - Kojić, Vesna
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1194
AB  - This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells
EP  - 620
IS  - 5
SP  - 616
VL  - 32
DO  - 10.1080/14786419.2017.1327959
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Glumac, Miodrag and Jakimov, Dimitar and Kojić, Vesna",
year = "2018",
abstract = "This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells",
pages = "620-616",
number = "5",
volume = "32",
doi = "10.1080/14786419.2017.1327959"
}

Pejin, B., Tommonaro, G., Glumac, M., Jakimov, D.,& Kojić, V.. (2018). The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(5), 616-620.
https://doi.org/10.1080/14786419.2017.1327959

Pejin B, Tommonaro G, Glumac M, Jakimov D, Kojić V. The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research. 2018;32(5):616-620.
doi:10.1080/14786419.2017.1327959 .

Pejin, Boris, Tommonaro, Giuseppina, Glumac, Miodrag, Jakimov, Dimitar, Kojić, Vesna, "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells" in Natural Product Research, 32, no. 5 (2018):616-620,
https://doi.org/10.1080/14786419.2017.1327959 . .

TY  - JOUR
AU  - Janjusević, Ljiljana
AU  - Karaman, Maja
AU  - Sibul, Filip
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Jakovljević, Dragica
AU  - Pejin, Boris
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1086
AB  - This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
EP  - 362
IS  - 1
SP  - 355
VL  - 32
DO  - 10.1080/14756366.2016.1252759
ER  - 

@article{
author = "Janjusević, Ljiljana and Karaman, Maja and Sibul, Filip and Tommonaro, Giuseppina and Iodice, Carmine and Jakovljević, Dragica and Pejin, Boris",
year = "2017",
abstract = "This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents",
pages = "362-355",
number = "1",
volume = "32",
doi = "10.1080/14756366.2016.1252759"
}

Janjusević, L., Karaman, M., Sibul, F., Tommonaro, G., Iodice, C., Jakovljević, D.,& Pejin, B.. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 355-362.
https://doi.org/10.1080/14756366.2016.1252759

Janjusević L, Karaman M, Sibul F, Tommonaro G, Iodice C, Jakovljević D, Pejin B. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):355-362.
doi:10.1080/14756366.2016.1252759 .

Janjusević, Ljiljana, Karaman, Maja, Sibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris, "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):355-362,
https://doi.org/10.1080/14756366.2016.1252759 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Kojić, Vesna
AU  - Jakimov, Dimitar
AU  - Lazović, Milica
AU  - Tommonaro, Giuseppina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/953
AB  - The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro evaluation of cytotoxic and mutagenic activity of avarol
EP  - 1296
IS  - 11
SP  - 1293
VL  - 30
DO  - 10.1080/14786419.2015.1052067
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Kojić, Vesna and Jakimov, Dimitar and Lazović, Milica and Tommonaro, Giuseppina",
year = "2016",
abstract = "The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro evaluation of cytotoxic and mutagenic activity of avarol",
pages = "1296-1293",
number = "11",
volume = "30",
doi = "10.1080/14786419.2015.1052067"
}

Pejin, B., Iodice, C., Kojić, V., Jakimov, D., Lazović, M.,& Tommonaro, G.. (2016). In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(11), 1293-1296.
https://doi.org/10.1080/14786419.2015.1052067

Pejin B, Iodice C, Kojić V, Jakimov D, Lazović M, Tommonaro G. In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research. 2016;30(11):1293-1296.
doi:10.1080/14786419.2015.1052067 .

Pejin, Boris, Iodice, Carmine, Kojić, Vesna, Jakimov, Dimitar, Lazović, Milica, Tommonaro, Giuseppina, "In vitro evaluation of cytotoxic and mutagenic activity of avarol" in Natural Product Research, 30, no. 11 (2016):1293-1296,
https://doi.org/10.1080/14786419.2015.1052067 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Marković, Dejan
AU  - Tommonaro, Giuseppina
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/997
AB  - This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro avarol does affect the growth of Candida sp.
EP  - 1960
IS  - 17
SP  - 1956
VL  - 30
DO  - 10.1080/14786419.2015.1091454
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Marković, Dejan and Tommonaro, Giuseppina and Soković, Marina",
year = "2016",
abstract = "This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro avarol does affect the growth of Candida sp.",
pages = "1960-1956",
number = "17",
volume = "30",
doi = "10.1080/14786419.2015.1091454"
}

Pejin, B., Ciric, A., Marković, D., Tommonaro, G.,& Soković, M.. (2016). In vitro avarol does affect the growth of Candida sp.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(17), 1956-1960.
https://doi.org/10.1080/14786419.2015.1091454

Pejin B, Ciric A, Marković D, Tommonaro G, Soković M. In vitro avarol does affect the growth of Candida sp.. in Natural Product Research. 2016;30(17):1956-1960.
doi:10.1080/14786419.2015.1091454 .

Pejin, Boris, Ciric, Ana, Marković, Dejan, Tommonaro, Giuseppina, Soković, Marina, "In vitro avarol does affect the growth of Candida sp." in Natural Product Research, 30, no. 17 (2016):1956-1960,
https://doi.org/10.1080/14786419.2015.1091454 . .

TY  - JOUR
AU  - Tommonaro, Giuseppina
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tafuto, Antonietta
AU  - De Rosa, Salvatore
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/995
AB  - The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05 mM and 0.50 mu g and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3)mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol
EP  - 686
IS  - 4
SP  - 684
VL  - 31
DO  - 10.3109/14756366.2015.1057724
ER  - 

@article{
author = "Tommonaro, Giuseppina and Pejin, Boris and Iodice, Carmine and Tafuto, Antonietta and De Rosa, Salvatore",
year = "2016",
abstract = "The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05 mM and 0.50 mu g and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3)mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol",
pages = "686-684",
number = "4",
volume = "31",
doi = "10.3109/14756366.2015.1057724"
}

Tommonaro, G., Pejin, B., Iodice, C., Tafuto, A.,& De Rosa, S.. (2016). Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 31(4), 684-686.
https://doi.org/10.3109/14756366.2015.1057724

Tommonaro G, Pejin B, Iodice C, Tafuto A, De Rosa S. Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(4):684-686.
doi:10.3109/14756366.2015.1057724 .

Tommonaro, Giuseppina, Pejin, Boris, Iodice, Carmine, Tafuto, Antonietta, De Rosa, Salvatore, "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol" in Journal of Enzyme Inhibition and Medicinal Chemistry, 31, no. 4 (2016):684-686,
https://doi.org/10.3109/14756366.2015.1057724 . .

TY  - JOUR
AU  - Tommonaro, Giuseppina
AU  - Garcia-Font, Nuria
AU  - Vitale, Rosa Maria
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Canadas, Sixta
AU  - Marco-Contelles, Jose
AU  - Jesus, Oset-Gasque, Maria
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1011
AB  - Avarol is a marine sesquiterpenoid hydroquinone, previously isolated from the marine sponge Dysidea avara Schmidt (Dictyoceratida), with antiinflammatory, antitumor, antioxidant, antiplatelet, anti-HIV, and antipsoriatic effects. Recent findings indicate that some thio-avarol derivatives exhibit acetylcholinesterase (AChE) inhibitory activity. The multiple pharmacological properties of avarol, thio-avarol and/or their derivatives prompted us to continue the in vitro screening, focusing on their AChE inhibitory and neuroprotective effects. Due to the complex nature of Alzheimer's disease (AD), there is a renewed search for new, non hepatotoxic anticholinesterasic compounds. This paper describes the synthesis and in vitro biological evaluation of avarol-3'-thiosalicylate (TAVA) and thiosalycil-prenyl-hydroquinones (TPHs), as non hepatotoxic anticholinesterasic agents, showing a good neuroprotective effect on the decreased viability of SHSY5Y human neuroblastoma cells induced by oligomycin A/rotenone and okadaic acid. A molecular modeling study was also undertaken on the most promising molecules within the series to elucidate their AChE binding modes and in particular the role played by the carboxylate group in enzyme inhibition. Among them, TPH4, bearing a geranylgeraniol substituent, is the most significant Electrophorus electricus AChE (EeAChE) inhibitor (IC50 = 6.77 +/- 0.24 M), also endowed with a moderate serum horse butyrylcholinesterase (eqBuChE) inhibitory activity, being also the least hepatotoxic and the best neuroprotective compound of the series. Thus, TPHs represents a new family of synthetic compounds, chemically related to the natural compound avarol, which has been discovered for the potential treatment of AD. Findings prove the relevance of TPHs as a new possible generation of competitive AChE inhibitors pointing out the importance of the salycilic substituents on the hydroquinone ring. Since these compounds do not belong to the class of alkaloids, which are notorious for their capability to inhibit AChE while exhibiting side effects, they may constitute novel active AChE inhibitors with fewer side effects.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease
EP  - 338
SP  - 326
VL  - 122
DO  - 10.1016/j.ejmech.2016.06.036
ER  - 

@article{
author = "Tommonaro, Giuseppina and Garcia-Font, Nuria and Vitale, Rosa Maria and Pejin, Boris and Iodice, Carmine and Canadas, Sixta and Marco-Contelles, Jose and Jesus, Oset-Gasque, Maria",
year = "2016",
abstract = "Avarol is a marine sesquiterpenoid hydroquinone, previously isolated from the marine sponge Dysidea avara Schmidt (Dictyoceratida), with antiinflammatory, antitumor, antioxidant, antiplatelet, anti-HIV, and antipsoriatic effects. Recent findings indicate that some thio-avarol derivatives exhibit acetylcholinesterase (AChE) inhibitory activity. The multiple pharmacological properties of avarol, thio-avarol and/or their derivatives prompted us to continue the in vitro screening, focusing on their AChE inhibitory and neuroprotective effects. Due to the complex nature of Alzheimer's disease (AD), there is a renewed search for new, non hepatotoxic anticholinesterasic compounds. This paper describes the synthesis and in vitro biological evaluation of avarol-3'-thiosalicylate (TAVA) and thiosalycil-prenyl-hydroquinones (TPHs), as non hepatotoxic anticholinesterasic agents, showing a good neuroprotective effect on the decreased viability of SHSY5Y human neuroblastoma cells induced by oligomycin A/rotenone and okadaic acid. A molecular modeling study was also undertaken on the most promising molecules within the series to elucidate their AChE binding modes and in particular the role played by the carboxylate group in enzyme inhibition. Among them, TPH4, bearing a geranylgeraniol substituent, is the most significant Electrophorus electricus AChE (EeAChE) inhibitor (IC50 = 6.77 +/- 0.24 M), also endowed with a moderate serum horse butyrylcholinesterase (eqBuChE) inhibitory activity, being also the least hepatotoxic and the best neuroprotective compound of the series. Thus, TPHs represents a new family of synthetic compounds, chemically related to the natural compound avarol, which has been discovered for the potential treatment of AD. Findings prove the relevance of TPHs as a new possible generation of competitive AChE inhibitors pointing out the importance of the salycilic substituents on the hydroquinone ring. Since these compounds do not belong to the class of alkaloids, which are notorious for their capability to inhibit AChE while exhibiting side effects, they may constitute novel active AChE inhibitors with fewer side effects.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease",
pages = "338-326",
volume = "122",
doi = "10.1016/j.ejmech.2016.06.036"
}

Tommonaro, G., Garcia-Font, N., Vitale, R. M., Pejin, B., Iodice, C., Canadas, S., Marco-Contelles, J.,& Jesus, O. M.. (2016). Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 122, 326-338.
https://doi.org/10.1016/j.ejmech.2016.06.036

Tommonaro G, Garcia-Font N, Vitale RM, Pejin B, Iodice C, Canadas S, Marco-Contelles J, Jesus OM. Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease. in European Journal of Medicinal Chemistry. 2016;122:326-338.
doi:10.1016/j.ejmech.2016.06.036 .

Tommonaro, Giuseppina, Garcia-Font, Nuria, Vitale, Rosa Maria, Pejin, Boris, Iodice, Carmine, Canadas, Sixta, Marco-Contelles, Jose, Jesus, Oset-Gasque, Maria, "Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease" in European Journal of Medicinal Chemistry, 122 (2016):326-338,
https://doi.org/10.1016/j.ejmech.2016.06.036 . .

TY  - JOUR
AU  - Tommonaro, Giuseppina
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tafuto, Antonietta
AU  - De Rosa, Salvatore
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/827
AB  - The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio-and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3) mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05mM and 0.50 mg and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3) mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol
EP  - 335
IS  - 2
SP  - 333
VL  - 30
DO  - 10.3109/14756366.2014.913037
ER  - 

@article{
author = "Tommonaro, Giuseppina and Pejin, Boris and Iodice, Carmine and Tafuto, Antonietta and De Rosa, Salvatore",
year = "2015",
abstract = "The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio-and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3) mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05mM and 0.50 mg and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3) mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol",
pages = "335-333",
number = "2",
volume = "30",
doi = "10.3109/14756366.2014.913037"
}

Tommonaro, G., Pejin, B., Iodice, C., Tafuto, A.,& De Rosa, S.. (2015). Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 30(2), 333-335.
https://doi.org/10.3109/14756366.2014.913037

Tommonaro G, Pejin B, Iodice C, Tafuto A, De Rosa S. Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2015;30(2):333-335.
doi:10.3109/14756366.2014.913037 .

Tommonaro, Giuseppina, Pejin, Boris, Iodice, Carmine, Tafuto, Antonietta, De Rosa, Salvatore, "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol" in Journal of Enzyme Inhibition and Medicinal Chemistry, 30, no. 2 (2015):333-335,
https://doi.org/10.3109/14756366.2014.913037 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Stanimirović, Bojana
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - De Rosa, Salvatore
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/776
AB  - This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol
EP  - 588
IS  - 6
SP  - 583
VL  - 15
DO  - 10.2174/138920101506140910152253
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Stanimirović, Bojana and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and De Rosa, Salvatore and Soković, Marina",
year = "2014",
abstract = "This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol",
pages = "588-583",
number = "6",
volume = "15",
doi = "10.2174/138920101506140910152253"
}

Pejin, B., Iodice, C., Tommonaro, G., Stanimirović, B., Ciric, A., Glamočlija, J., Nikolic, M., De Rosa, S.,& Soković, M.. (2014). Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 15(6), 583-588.
https://doi.org/10.2174/138920101506140910152253

Pejin B, Iodice C, Tommonaro G, Stanimirović B, Ciric A, Glamočlija J, Nikolic M, De Rosa S, Soković M. Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology. 2014;15(6):583-588.
doi:10.2174/138920101506140910152253 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Stanimirović, Bojana, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, De Rosa, Salvatore, Soković, Marina, "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol" in Current Pharmaceutical Biotechnology, 15, no. 6 (2014):583-588,
https://doi.org/10.2174/138920101506140910152253 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna 
AU  - De Rosa, Salvatore
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/779
AB  - The cytotoxicity of 4-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40M and 9.62M, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64M and 17.31M, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24M and 15.54M, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone
EP  - 350
IS  - 5
SP  - 347
VL  - 28
DO  - 10.1080/14786419.2013.863201
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Bogdanović, Gordana and Kojić, Vesna  and De Rosa, Salvatore",
year = "2014",
abstract = "The cytotoxicity of 4-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40M and 9.62M, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64M and 17.31M, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24M and 15.54M, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone",
pages = "350-347",
number = "5",
volume = "28",
doi = "10.1080/14786419.2013.863201"
}

Pejin, B., Iodice, C., Tommonaro, G., Bogdanović, G., Kojić, V.,& De Rosa, S.. (2014). Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(5), 347-350.
https://doi.org/10.1080/14786419.2013.863201

Pejin B, Iodice C, Tommonaro G, Bogdanović G, Kojić V, De Rosa S. Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone. in Natural Product Research. 2014;28(5):347-350.
doi:10.1080/14786419.2013.863201 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Bogdanović, Gordana, Kojić, Vesna , De Rosa, Salvatore, "Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone" in Natural Product Research, 28, no. 5 (2014):347-350,
https://doi.org/10.1080/14786419.2013.863201 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, Salvatore
PY  - 2013
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/660
AB  - The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.
PB  - Informa Healthcare, London
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity
EP  - 878
IS  - 4
SP  - 876
VL  - 28
DO  - 10.3109/14756366.2012.677839
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka E and De Rosa, Salvatore",
year = "2013",
abstract = "The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.",
publisher = "Informa Healthcare, London",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity",
pages = "878-876",
number = "4",
volume = "28",
doi = "10.3109/14756366.2012.677839"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2013). A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry
Informa Healthcare, London., 28(4), 876-878.
https://doi.org/10.3109/14756366.2012.677839

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs VE, De Rosa S. A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):876-878.
doi:10.3109/14756366.2012.677839 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka E, De Rosa, Salvatore, "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):876-878,
https://doi.org/10.3109/14756366.2012.677839 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Sabovljević, Marko S
AU  - Bianco, Armandodoriano
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, Salvatore
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/577
AB  - Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.
EP  - 215
IS  - 3
SP  - 209
VL  - 26
DO  - 10.1080/14786419.2010.535163
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Sabovljević, Marko S and Bianco, Armandodoriano and Tešević, Vele and Vajs, Vlatka E and De Rosa, Salvatore",
year = "2012",
abstract = "Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.",
pages = "215-209",
number = "3",
volume = "26",
doi = "10.1080/14786419.2010.535163"
}

Pejin, B., Iodice, C., Tommonaro, G., Sabovljević, M. S., Bianco, A., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2012). Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(3), 209-215.
https://doi.org/10.1080/14786419.2010.535163

Pejin B, Iodice C, Tommonaro G, Sabovljević MS, Bianco A, Tešević V, Vajs VE, De Rosa S. Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research. 2012;26(3):209-215.
doi:10.1080/14786419.2010.535163 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Sabovljević, Marko S, Bianco, Armandodoriano, Tešević, Vele, Vajs, Vlatka E, De Rosa, Salvatore, "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb." in Natural Product Research, 26, no. 3 (2012):209-215,
https://doi.org/10.1080/14786419.2010.535163 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, S.
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/620
AB  - The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.
PB  - Inst Materials Physics
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - A new lichen depsidone from l obaria pulmonaria
EP  - 1666
IS  - 4
SP  - 1663
VL  - 7
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1566
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka E and De Rosa, S.",
year = "2012",
abstract = "The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.",
publisher = "Inst Materials Physics",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "A new lichen depsidone from l obaria pulmonaria",
pages = "1666-1663",
number = "4",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1566"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2012). A new lichen depsidone from l obaria pulmonaria. in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics., 7(4), 1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs VE, De Rosa S. A new lichen depsidone from l obaria pulmonaria. in Digest Journal of Nanomaterials and Biostructures. 2012;7(4):1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka E, De Rosa, S., "A new lichen depsidone from l obaria pulmonaria" in Digest Journal of Nanomaterials and Biostructures, 7, no. 4 (2012):1663-1666,
https://hdl.handle.net/21.15107/rcub_cherry_1566 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/591
AB  - As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria
EP  - 1637
IS  - 17
SP  - 1634
VL  - 26
DO  - 10.1080/14786419.2011.585989
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka E",
year = "2012",
abstract = "As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria",
pages = "1637-1634",
number = "17",
volume = "26",
doi = "10.1080/14786419.2011.585989"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V. E.. (2012). Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(17), 1634-1637.
https://doi.org/10.1080/14786419.2011.585989

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs VE. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research. 2012;26(17):1634-1637.
doi:10.1080/14786419.2011.585989 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka E, "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria" in Natural Product Research, 26, no. 17 (2012):1634-1637,
https://doi.org/10.1080/14786419.2011.585989 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/538
AB  - A phytochemical investigation conducted on a folise lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina led to a mixture of methylated depsidones which showed acetylcholinesterase inhibition activity (2 mu g) in the acetylcholinesterase inhibition test on thin-layer chromatography plate. Present results indicate for the first time the potential of methylated depsidones in searching for these inhibitors, which still represent the best drugs currently available for the management of Alzheimer's disease.
PB  - Asian Journal Of Chemistry, Sahibabad
T2  - Asian Journal of Chemistry
T1  - Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria
EP  - 3262
IS  - 7
SP  - 3261
VL  - 24
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1306
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka E",
year = "2012",
abstract = "A phytochemical investigation conducted on a folise lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina led to a mixture of methylated depsidones which showed acetylcholinesterase inhibition activity (2 mu g) in the acetylcholinesterase inhibition test on thin-layer chromatography plate. Present results indicate for the first time the potential of methylated depsidones in searching for these inhibitors, which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Asian Journal Of Chemistry, Sahibabad",
journal = "Asian Journal of Chemistry",
title = "Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria",
pages = "3262-3261",
number = "7",
volume = "24",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1306"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V. E.. (2012). Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria. in Asian Journal of Chemistry
Asian Journal Of Chemistry, Sahibabad., 24(7), 3261-3262.
https://hdl.handle.net/21.15107/rcub_cherry_1306

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs VE. Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria. in Asian Journal of Chemistry. 2012;24(7):3261-3262.
https://hdl.handle.net/21.15107/rcub_cherry_1306 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka E, "Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria" in Asian Journal of Chemistry, 24, no. 7 (2012):3261-3262,
https://hdl.handle.net/21.15107/rcub_cherry_1306 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - De Rosa, Salvatore
PY  - 2008
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/281
AB  - Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thioavarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Synthesis and Biological Activities of Thio-avarol Derivatives
EP  - 1853
IS  - 11
SP  - 1850
VL  - 71
DO  - 10.1021/np800318m
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and De Rosa, Salvatore",
year = "2008",
abstract = "Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thioavarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Synthesis and Biological Activities of Thio-avarol Derivatives",
pages = "1853-1850",
number = "11",
volume = "71",
doi = "10.1021/np800318m"
}

Pejin, B., Iodice, C., Tommonaro, G.,& De Rosa, S.. (2008). Synthesis and Biological Activities of Thio-avarol Derivatives. in Journal of Natural Products
Amer Chemical Soc, Washington., 71(11), 1850-1853.
https://doi.org/10.1021/np800318m

Pejin B, Iodice C, Tommonaro G, De Rosa S. Synthesis and Biological Activities of Thio-avarol Derivatives. in Journal of Natural Products. 2008;71(11):1850-1853.
doi:10.1021/np800318m .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, De Rosa, Salvatore, "Synthesis and Biological Activities of Thio-avarol Derivatives" in Journal of Natural Products, 71, no. 11 (2008):1850-1853,
https://doi.org/10.1021/np800318m . .