TY  - JOUR
AU  - Karaman, Maja
AU  - Atlagic, Kristina
AU  - Novaković, Aleksandra
AU  - Sibul, Filip
AU  - Zivić, Miroslav
AU  - Stevanović, Katarina
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1198
AB  - Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH center dot, 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids-more precisely, unsaturated fatty acids (UFAs) followed by fatty acids possessing both short (C6:0 and C8:0) and long (C23:0 and C24:0) saturated chains-and phenolic compounds (such as protocatechuic acid, daidzein, p-hydroxybenzoic acid, genistein and vanillic acid) for promising anti-OH center dot, FRAP and anti-DPPH center dot activities, respectively. However, other fatty acids (C16:0, C18:0 and C18:3n3) along with the flavonol isorhamnetin are actually suspected to negatively affect (by acting pro-oxidative) the aforementioned parameters, respectively. Taken together, design of new food supplements targeting oxidative stress might be predominantly based on the various UFAs combinations (C18:2n6, C20:1, C20:2, C20:4n6, C22:2, C22:1n9, etc.), particularly if OH center dot is suspected to play an important role.
PB  - MDPI, Basel
T2  - Antioxidants
T1  - Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms
IS  - 10
VL  - 8
DO  - 10.3390/antiox8100480
ER  - 

@article{
author = "Karaman, Maja and Atlagic, Kristina and Novaković, Aleksandra and Sibul, Filip and Zivić, Miroslav and Stevanović, Katarina and Pejin, Boris",
year = "2019",
abstract = "Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH center dot, 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids-more precisely, unsaturated fatty acids (UFAs) followed by fatty acids possessing both short (C6:0 and C8:0) and long (C23:0 and C24:0) saturated chains-and phenolic compounds (such as protocatechuic acid, daidzein, p-hydroxybenzoic acid, genistein and vanillic acid) for promising anti-OH center dot, FRAP and anti-DPPH center dot activities, respectively. However, other fatty acids (C16:0, C18:0 and C18:3n3) along with the flavonol isorhamnetin are actually suspected to negatively affect (by acting pro-oxidative) the aforementioned parameters, respectively. Taken together, design of new food supplements targeting oxidative stress might be predominantly based on the various UFAs combinations (C18:2n6, C20:1, C20:2, C20:4n6, C22:2, C22:1n9, etc.), particularly if OH center dot is suspected to play an important role.",
publisher = "MDPI, Basel",
journal = "Antioxidants",
title = "Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms",
number = "10",
volume = "8",
doi = "10.3390/antiox8100480"
}

Karaman, M., Atlagic, K., Novaković, A., Sibul, F., Zivić, M., Stevanović, K.,& Pejin, B.. (2019). Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms. in Antioxidants
MDPI, Basel., 8(10).
https://doi.org/10.3390/antiox8100480

Karaman M, Atlagic K, Novaković A, Sibul F, Zivić M, Stevanović K, Pejin B. Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms. in Antioxidants. 2019;8(10).
doi:10.3390/antiox8100480 .

Karaman, Maja, Atlagic, Kristina, Novaković, Aleksandra, Sibul, Filip, Zivić, Miroslav, Stevanović, Katarina, Pejin, Boris, "Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms" in Antioxidants, 8, no. 10 (2019),
https://doi.org/10.3390/antiox8100480 . .

TY  - CONF
AU  - Žižić, Milan
AU  - Tešanović, Kristina
AU  - Karaman, Maja
AU  - Zakrzewska, Joanna
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2207
AB  - Laetiporus sulphureus (Bull.) Murrill 1920, (Ph. Basidiomycota, Cl. Agaricomycetes, O. Polyporales, Fam. Polyporaceae) je jestiva gljiva, široko rasprostranjena u Evropi, Aziji i Severnoj Americi. Izolovana micelija autohtone gljive (vrba obala Dunava, Novi Sad) kultivisana je na čvrstoj podlozi i u potopljenom medijumu. Cilj istraživanja bio je da se upotrebom NMR spektroskopije ispita uticaj vanadijuma na metabolizam fosfata. Utvrđeno je da signali pozicionirani oko 4 ppm i 2,6 ppm pripadaju šećernim fosfatima (SP) i da nakon tretmana sa 10 mM vanadatom dolazi do povećanja signala za 78%, odnosno 23%. Nakon ispiranja micelijuma dolazi do postepene transformacije jednog oblika u drugi, tako da posle sat vremena signal SP na 2,6 ppm postaje dominantan u odnosu na signal pozicioniran na 4 ppm. Promene signala SP mogu ukazati na efektivnost inhibitora ili stimulatora energetskog metabolizma. Pored SP, polifosfati (PolyP) prisutni u miceliji gljive, takođe imaju ulogu u skladištenju energije. Primećeno je da se nakon izlaganja nepovoljnjim uslovima signal PolyP smanjio, što je potvrđeno u studijama sa kvascima S. cereviseae1 i N. crassa2. Nasuprot tome, nakon tretmana vanadijumom kod L. sulphureus nije došlo do redukcije signala PolyP, već je zabeležen mali porast signala dugolančanih polifosfata što može ukazati na mehanizam detoksifikacije micelije L. sulphureus kao metaboličkog odgovora micelije na dodavanje vanadata.
PB  - Srpsko biološko društvo, Beograd
C3  - DRUGI KONGRES BIOLOGA SRBIJE
T1  - Uticaj vanadata na vremensko-zavisni metabolički odgovor micelije Laetiporus sulphureus
EP  - 36
SP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2207
ER  - 

@conference{
author = "Žižić, Milan and Tešanović, Kristina and Karaman, Maja and Zakrzewska, Joanna",
year = "2018",
abstract = "Laetiporus sulphureus (Bull.) Murrill 1920, (Ph. Basidiomycota, Cl. Agaricomycetes, O. Polyporales, Fam. Polyporaceae) je jestiva gljiva, široko rasprostranjena u Evropi, Aziji i Severnoj Americi. Izolovana micelija autohtone gljive (vrba obala Dunava, Novi Sad) kultivisana je na čvrstoj podlozi i u potopljenom medijumu. Cilj istraživanja bio je da se upotrebom NMR spektroskopije ispita uticaj vanadijuma na metabolizam fosfata. Utvrđeno je da signali pozicionirani oko 4 ppm i 2,6 ppm pripadaju šećernim fosfatima (SP) i da nakon tretmana sa 10 mM vanadatom dolazi do povećanja signala za 78%, odnosno 23%. Nakon ispiranja micelijuma dolazi do postepene transformacije jednog oblika u drugi, tako da posle sat vremena signal SP na 2,6 ppm postaje dominantan u odnosu na signal pozicioniran na 4 ppm. Promene signala SP mogu ukazati na efektivnost inhibitora ili stimulatora energetskog metabolizma. Pored SP, polifosfati (PolyP) prisutni u miceliji gljive, takođe imaju ulogu u skladištenju energije. Primećeno je da se nakon izlaganja nepovoljnjim uslovima signal PolyP smanjio, što je potvrđeno u studijama sa kvascima S. cereviseae1 i N. crassa2. Nasuprot tome, nakon tretmana vanadijumom kod L. sulphureus nije došlo do redukcije signala PolyP, već je zabeležen mali porast signala dugolančanih polifosfata što može ukazati na mehanizam detoksifikacije micelije L. sulphureus kao metaboličkog odgovora micelije na dodavanje vanadata.",
publisher = "Srpsko biološko društvo, Beograd",
journal = "DRUGI KONGRES BIOLOGA SRBIJE",
title = "Uticaj vanadata na vremensko-zavisni metabolički odgovor micelije Laetiporus sulphureus",
pages = "36-36",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2207"
}

Žižić, M., Tešanović, K., Karaman, M.,& Zakrzewska, J.. (2018). Uticaj vanadata na vremensko-zavisni metabolički odgovor micelije Laetiporus sulphureus. in DRUGI KONGRES BIOLOGA SRBIJE
Srpsko biološko društvo, Beograd., 36-36.
https://hdl.handle.net/21.15107/rcub_rimsi_2207

Žižić M, Tešanović K, Karaman M, Zakrzewska J. Uticaj vanadata na vremensko-zavisni metabolički odgovor micelije Laetiporus sulphureus. in DRUGI KONGRES BIOLOGA SRBIJE. 2018;:36-36.
https://hdl.handle.net/21.15107/rcub_rimsi_2207 .

Žižić, Milan, Tešanović, Kristina, Karaman, Maja, Zakrzewska, Joanna, "Uticaj vanadata na vremensko-zavisni metabolički odgovor micelije Laetiporus sulphureus" in DRUGI KONGRES BIOLOGA SRBIJE (2018):36-36,
https://hdl.handle.net/21.15107/rcub_rimsi_2207 .

TY  - JOUR
AU  - Žižić, Milan
AU  - Zakrzewska, Joanna
AU  - Tesanović, Kristina
AU  - Bosković, Eleonora
AU  - Nesović, Milica
AU  - Karaman, Maja
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1119
AB  - Vanadate is proposed to play a pivotal role in application of edible fungus Coprinus comatus for medical purposes. In this study the concentration of extracellular vanadate acceptable for the submerged cultivation of C. comatus mycelium was established. The mycelium could grow, and overcome vanadate toxic effects, up to the concentration of 3.3 mM. Moreover, in this condition, at the end of the exponential phase of growth, biomass yield was almost identical to that in the control. P-31 NMR spectroscopy showed that addition of 10 mM vanadate to the mycelium in the exponential phase of growth provoked instantaneous increase of a sugar phosphates level which could be related to changes in activities of glycolytic enzymes. Exposure to higher vanadate concentration was toxic for the cell. V-51 NMR measurements revealed that monomer of vanadate is present in the cytoplasm causing the metabolic changes. C. comatus has also capacity for vanadate reduction, as shown by EPR measurements, but vanadyl uptake is significantly less comparing to vanadate.
PB  - Elsevier Gmbh, Munich
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Effects of vanadate on the mycelium of edible fungus Coprinus comatus
EP  - 326
SP  - 320
VL  - 50
DO  - 10.1016/j.jtemb.2018.07.017
ER  - 

@article{
author = "Žižić, Milan and Zakrzewska, Joanna and Tesanović, Kristina and Bosković, Eleonora and Nesović, Milica and Karaman, Maja",
year = "2018",
abstract = "Vanadate is proposed to play a pivotal role in application of edible fungus Coprinus comatus for medical purposes. In this study the concentration of extracellular vanadate acceptable for the submerged cultivation of C. comatus mycelium was established. The mycelium could grow, and overcome vanadate toxic effects, up to the concentration of 3.3 mM. Moreover, in this condition, at the end of the exponential phase of growth, biomass yield was almost identical to that in the control. P-31 NMR spectroscopy showed that addition of 10 mM vanadate to the mycelium in the exponential phase of growth provoked instantaneous increase of a sugar phosphates level which could be related to changes in activities of glycolytic enzymes. Exposure to higher vanadate concentration was toxic for the cell. V-51 NMR measurements revealed that monomer of vanadate is present in the cytoplasm causing the metabolic changes. C. comatus has also capacity for vanadate reduction, as shown by EPR measurements, but vanadyl uptake is significantly less comparing to vanadate.",
publisher = "Elsevier Gmbh, Munich",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Effects of vanadate on the mycelium of edible fungus Coprinus comatus",
pages = "326-320",
volume = "50",
doi = "10.1016/j.jtemb.2018.07.017"
}

Žižić, M., Zakrzewska, J., Tesanović, K., Bosković, E., Nesović, M.,& Karaman, M.. (2018). Effects of vanadate on the mycelium of edible fungus Coprinus comatus. in Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Munich., 50, 320-326.
https://doi.org/10.1016/j.jtemb.2018.07.017

Žižić M, Zakrzewska J, Tesanović K, Bosković E, Nesović M, Karaman M. Effects of vanadate on the mycelium of edible fungus Coprinus comatus. in Journal of Trace Elements in Medicine and Biology. 2018;50:320-326.
doi:10.1016/j.jtemb.2018.07.017 .

Žižić, Milan, Zakrzewska, Joanna, Tesanović, Kristina, Bosković, Eleonora, Nesović, Milica, Karaman, Maja, "Effects of vanadate on the mycelium of edible fungus Coprinus comatus" in Journal of Trace Elements in Medicine and Biology, 50 (2018):320-326,
https://doi.org/10.1016/j.jtemb.2018.07.017 . .

TY  - JOUR
AU  - Janjusević, Ljiljana
AU  - Pejin, Boris
AU  - Kaisarević, Sonja
AU  - Gorjanović, Stanislava
AU  - Pastor, Ferenc
AU  - Tesanović, Kristina
AU  - Karaman, Maja
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1154
AB  - This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement
EP  - 967
IS  - 8
SP  - 963
VL  - 32
DO  - 10.1080/14786419.2017.1366484
ER  - 

@article{
author = "Janjusević, Ljiljana and Pejin, Boris and Kaisarević, Sonja and Gorjanović, Stanislava and Pastor, Ferenc and Tesanović, Kristina and Karaman, Maja",
year = "2018",
abstract = "This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement",
pages = "967-963",
number = "8",
volume = "32",
doi = "10.1080/14786419.2017.1366484"
}

Janjusević, L., Pejin, B., Kaisarević, S., Gorjanović, S., Pastor, F., Tesanović, K.,& Karaman, M.. (2018). Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(8), 963-967.
https://doi.org/10.1080/14786419.2017.1366484

Janjusević L, Pejin B, Kaisarević S, Gorjanović S, Pastor F, Tesanović K, Karaman M. Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research. 2018;32(8):963-967.
doi:10.1080/14786419.2017.1366484 .

Janjusević, Ljiljana, Pejin, Boris, Kaisarević, Sonja, Gorjanović, Stanislava, Pastor, Ferenc, Tesanović, Kristina, Karaman, Maja, "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement" in Natural Product Research, 32, no. 8 (2018):963-967,
https://doi.org/10.1080/14786419.2017.1366484 . .

TY  - JOUR
AU  - Glumac, Miodrag
AU  - Pejin, Boris
AU  - Karaman, Maja
AU  - Mojović, Miloš
AU  - Matavulj, Milan
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1093
AB  - In vitro evaluation of total phenolic contents and antiradical activities of the lignicolous fungi Fomes fomentarius and Schizophyllum commune hydrodistilled extracts was the subject of this study. This preliminary screening included four free radical species evaluated by UV-vis (DPPH center dot, ABTS(center dot) and (NO)-N-center dot) and EPR (Asc(center dot)), respectively. According to the experimental data obtained, both F. fomentarius and S. commune hydrodistilled extracts may be considered as promising sources of phenolic natural products (157 and 138mg GAE/g d.e., respectively) and other bioactives showing good anti-DPPH (1.31g/mL) and anti-Asc (70.40%) radical activities, respectively, at in vitro conditions.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics
EP  - 107
IS  - 1
SP  - 104
VL  - 31
DO  - 10.1080/14786419.2016.1212036
ER  - 

@article{
author = "Glumac, Miodrag and Pejin, Boris and Karaman, Maja and Mojović, Miloš and Matavulj, Milan",
year = "2017",
abstract = "In vitro evaluation of total phenolic contents and antiradical activities of the lignicolous fungi Fomes fomentarius and Schizophyllum commune hydrodistilled extracts was the subject of this study. This preliminary screening included four free radical species evaluated by UV-vis (DPPH center dot, ABTS(center dot) and (NO)-N-center dot) and EPR (Asc(center dot)), respectively. According to the experimental data obtained, both F. fomentarius and S. commune hydrodistilled extracts may be considered as promising sources of phenolic natural products (157 and 138mg GAE/g d.e., respectively) and other bioactives showing good anti-DPPH (1.31g/mL) and anti-Asc (70.40%) radical activities, respectively, at in vitro conditions.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics",
pages = "107-104",
number = "1",
volume = "31",
doi = "10.1080/14786419.2016.1212036"
}

Glumac, M., Pejin, B., Karaman, M., Mojović, M.,& Matavulj, M.. (2017). Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(1), 104-107.
https://doi.org/10.1080/14786419.2016.1212036

Glumac M, Pejin B, Karaman M, Mojović M, Matavulj M. Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics. in Natural Product Research. 2017;31(1):104-107.
doi:10.1080/14786419.2016.1212036 .

Glumac, Miodrag, Pejin, Boris, Karaman, Maja, Mojović, Miloš, Matavulj, Milan, "Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics" in Natural Product Research, 31, no. 1 (2017):104-107,
https://doi.org/10.1080/14786419.2016.1212036 . .

TY  - JOUR
AU  - Tesanović, Kristina
AU  - Pejin, Boris
AU  - Sibul, Filip
AU  - Matavulj, Milan
AU  - Raseta, Milena
AU  - Janjusević, Ljiljana
AU  - Karaman, Maja
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1095
AB  - Bioactive properties of fungi considerably differ between the fruiting body (FB) and the submerged culture as regards mycelia (M) and the fermentation broth (F). Antioxidant properties of hot-water extracts obtained from three different fungal origins: FB, M and F of two autochthonous fungal species (Northern Serbia), Coprinus comatus and Coprinellus truncorum were investigated. Free radical scavenging capacity (RSC) was evaluated in vitro by the DPPH assay and reducing power ability (FRAP assay). Considering possible bioactive properties of different compounds present in fungal extracts, the content of total proteins (TP), phenols (TC) and flavonoids (TF) were investigated colorimetrically. The chemical characterisation of the examined extracts was evaluated using the HPLC-MS/MS method. C. comatus showed the strongest RSC activity; more precisely, fermentation broth extract (FCc) on DPPH radicals (IC50 = 5.06 mu g mL(-1)) and fruiting body extract (FBCc) for the FRAP assay (42.86 mg ascorbic acid equivalents (AAE)/g). Submerged M extract of both species showed the highest TC (MCc 81.95 mg gallic acid eq (GAE)/g d.w.; MCt 81.64 mg GAE/g d.w.), while FB extracts contained the highest content of TP. Comparing LC-MS phenolic profiles between species-interspecifically and among different fungal origins-intraspecifically (fruiting bodies and submerged cultures), high variations were noticed. In submerged M or F extracts of C. comatus, vanillic, gallic, gentisic and cinnamic acids were detected, as opposed to FB. Considering that diverse phenolic profiles of detected antioxidant compounds were obtained by submerged cultivation, this type of cultivation is promising for the production of antioxidant substances.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum
EP  - 438
IS  - 2
SP  - 430
VL  - 54
DO  - 10.1007/s13197-016-2479-2
ER  - 

@article{
author = "Tesanović, Kristina and Pejin, Boris and Sibul, Filip and Matavulj, Milan and Raseta, Milena and Janjusević, Ljiljana and Karaman, Maja",
year = "2017",
abstract = "Bioactive properties of fungi considerably differ between the fruiting body (FB) and the submerged culture as regards mycelia (M) and the fermentation broth (F). Antioxidant properties of hot-water extracts obtained from three different fungal origins: FB, M and F of two autochthonous fungal species (Northern Serbia), Coprinus comatus and Coprinellus truncorum were investigated. Free radical scavenging capacity (RSC) was evaluated in vitro by the DPPH assay and reducing power ability (FRAP assay). Considering possible bioactive properties of different compounds present in fungal extracts, the content of total proteins (TP), phenols (TC) and flavonoids (TF) were investigated colorimetrically. The chemical characterisation of the examined extracts was evaluated using the HPLC-MS/MS method. C. comatus showed the strongest RSC activity; more precisely, fermentation broth extract (FCc) on DPPH radicals (IC50 = 5.06 mu g mL(-1)) and fruiting body extract (FBCc) for the FRAP assay (42.86 mg ascorbic acid equivalents (AAE)/g). Submerged M extract of both species showed the highest TC (MCc 81.95 mg gallic acid eq (GAE)/g d.w.; MCt 81.64 mg GAE/g d.w.), while FB extracts contained the highest content of TP. Comparing LC-MS phenolic profiles between species-interspecifically and among different fungal origins-intraspecifically (fruiting bodies and submerged cultures), high variations were noticed. In submerged M or F extracts of C. comatus, vanillic, gallic, gentisic and cinnamic acids were detected, as opposed to FB. Considering that diverse phenolic profiles of detected antioxidant compounds were obtained by submerged cultivation, this type of cultivation is promising for the production of antioxidant substances.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum",
pages = "438-430",
number = "2",
volume = "54",
doi = "10.1007/s13197-016-2479-2"
}

Tesanović, K., Pejin, B., Sibul, F., Matavulj, M., Raseta, M., Janjusević, L.,& Karaman, M.. (2017). A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 54(2), 430-438.
https://doi.org/10.1007/s13197-016-2479-2

Tesanović K, Pejin B, Sibul F, Matavulj M, Raseta M, Janjusević L, Karaman M. A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum. in Journal of Food Science and Technology-Mysore. 2017;54(2):430-438.
doi:10.1007/s13197-016-2479-2 .

Tesanović, Kristina, Pejin, Boris, Sibul, Filip, Matavulj, Milan, Raseta, Milena, Janjusević, Ljiljana, Karaman, Maja, "A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum" in Journal of Food Science and Technology-Mysore, 54, no. 2 (2017):430-438,
https://doi.org/10.1007/s13197-016-2479-2 . .

TY  - JOUR
AU  - Janjusević, Ljiljana
AU  - Karaman, Maja
AU  - Sibul, Filip
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Jakovljević, Dragica
AU  - Pejin, Boris
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1086
AB  - This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
EP  - 362
IS  - 1
SP  - 355
VL  - 32
DO  - 10.1080/14756366.2016.1252759
ER  - 

@article{
author = "Janjusević, Ljiljana and Karaman, Maja and Sibul, Filip and Tommonaro, Giuseppina and Iodice, Carmine and Jakovljević, Dragica and Pejin, Boris",
year = "2017",
abstract = "This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents",
pages = "362-355",
number = "1",
volume = "32",
doi = "10.1080/14756366.2016.1252759"
}

Janjusević, L., Karaman, M., Sibul, F., Tommonaro, G., Iodice, C., Jakovljević, D.,& Pejin, B.. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 355-362.
https://doi.org/10.1080/14756366.2016.1252759

Janjusević L, Karaman M, Sibul F, Tommonaro G, Iodice C, Jakovljević D, Pejin B. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):355-362.
doi:10.1080/14756366.2016.1252759 .

Janjusević, Ljiljana, Karaman, Maja, Sibul, Filip, Tommonaro, Giuseppina, Iodice, Carmine, Jakovljević, Dragica, Pejin, Boris, "The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):355-362,
https://doi.org/10.1080/14756366.2016.1252759 . .