TY  - JOUR
AU  - Pejin, Boris
AU  - Stosic-Grujicic, Stanislava
AU  - Bogdanović, Gordana
AU  - Hegediš, Aleksandar
AU  - Karaman, I.
AU  - Stojanović, I.
AU  - Nikolić, Ivan
AU  - Kojic, V.
AU  - Horvatović, Mladen
AU  - Radotić, Ksenija
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/619
AB  - The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.
PB  - Inst Materials Physics
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract
EP  - 195
IS  - 1
SP  - 187
VL  - 8
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_619
ER  - 

@article{
author = "Pejin, Boris and Stosic-Grujicic, Stanislava and Bogdanović, Gordana and Hegediš, Aleksandar and Karaman, I. and Stojanović, I. and Nikolić, Ivan and Kojic, V. and Horvatović, Mladen and Radotić, Ksenija",
year = "2012",
abstract = "The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.",
publisher = "Inst Materials Physics",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract",
pages = "195-187",
number = "1",
volume = "8",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_619"
}

Pejin, B., Stosic-Grujicic, S., Bogdanović, G., Hegediš, A., Karaman, I., Stojanović, I., Nikolić, I., Kojic, V., Horvatović, M.,& Radotić, K.. (2012). In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract. in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics., 8(1), 187-195.
https://hdl.handle.net/21.15107/rcub_rimsi_619

Pejin B, Stosic-Grujicic S, Bogdanović G, Hegediš A, Karaman I, Stojanović I, Nikolić I, Kojic V, Horvatović M, Radotić K. In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract. in Digest Journal of Nanomaterials and Biostructures. 2012;8(1):187-195.
https://hdl.handle.net/21.15107/rcub_rimsi_619 .

Pejin, Boris, Stosic-Grujicic, Stanislava, Bogdanović, Gordana, Hegediš, Aleksandar, Karaman, I., Stojanović, I., Nikolić, Ivan, Kojic, V., Horvatović, Mladen, Radotić, Ksenija, "In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract" in Digest Journal of Nanomaterials and Biostructures, 8, no. 1 (2012):187-195,
https://hdl.handle.net/21.15107/rcub_rimsi_619 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glamočlija, Jasmina
AU  - Ciric, A.
AU  - Radotić, Ksenija
AU  - Vajs, Vlatka E
AU  - Tešević, Vele
AU  - Hegediš, Aleksandar
AU  - Karaman, I.
AU  - Horvatović, Mladen
AU  - Soković, Marina
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/614
AB  - The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).
PB  - Inst Materials Physics
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)
EP  - 1026
IS  - 3
SP  - 1021
VL  - 7
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1565
ER  - 

@article{
author = "Pejin, Boris and Glamočlija, Jasmina and Ciric, A. and Radotić, Ksenija and Vajs, Vlatka E and Tešević, Vele and Hegediš, Aleksandar and Karaman, I. and Horvatović, Mladen and Soković, Marina",
year = "2012",
abstract = "The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).",
publisher = "Inst Materials Physics",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)",
pages = "1026-1021",
number = "3",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1565"
}

Pejin, B., Glamočlija, J., Ciric, A., Radotić, K., Vajs, V. E., Tešević, V., Hegediš, A., Karaman, I., Horvatović, M.,& Soković, M.. (2012). Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics., 7(3), 1021-1026.
https://hdl.handle.net/21.15107/rcub_cherry_1565

Pejin B, Glamočlija J, Ciric A, Radotić K, Vajs VE, Tešević V, Hegediš A, Karaman I, Horvatović M, Soković M. Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures. 2012;7(3):1021-1026.
https://hdl.handle.net/21.15107/rcub_cherry_1565 .

Pejin, Boris, Glamočlija, Jasmina, Ciric, A., Radotić, Ksenija, Vajs, Vlatka E, Tešević, Vele, Hegediš, Aleksandar, Karaman, I., Horvatović, Mladen, Soković, Marina, "Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)" in Digest Journal of Nanomaterials and Biostructures, 7, no. 3 (2012):1021-1026,
https://hdl.handle.net/21.15107/rcub_cherry_1565 .