TY  - CONF
AU  - Platisa, Mirjana M.
AU  - Radovanović, N.N.
AU  - Kalauzi, Aleksandar
AU  - Milasinović, G.
AU  - Pavlović, S.U.
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1306
AB  - Heart rate (HR) asymmetry is a dynamic phenomenon related to the interplay of dominant regulatory mechanisms of cardiovascular system which operate over different scales of observation. The aim of this work is to examine asymmetry phenomenon in heart failure (HF) patients with sinus rhythm. We computed Guzik's index of heart rate asymmetry related to HR deceleration (Cd) from the Poincare plot (Pp) analysis extended up to 20th order. In the control group asymmetry is maintained over all orders of the Pp. In HF patients with asymmetric properties, Cd is reduced in the range between 2nd and 5th order of the Pp analysis, compared the control subjects. More, this method revealed two clusters of HF patients. In conclusion, proposed new approach can be applied to reveal alterations in the behavior of the cardiovascular control mechanisms in pathological conditions.
PB  - Institute of Electrical and Electronics Engineers Inc.
C3  - 2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Mod
T1  - Asymmetry of Cardiac Interbeat Intervals in Heart Failure
DO  - 10.1109/ESGCO49734.2020.9158154
ER  - 

@conference{
author = "Platisa, Mirjana M. and Radovanović, N.N. and Kalauzi, Aleksandar and Milasinović, G. and Pavlović, S.U.",
year = "2020",
abstract = "Heart rate (HR) asymmetry is a dynamic phenomenon related to the interplay of dominant regulatory mechanisms of cardiovascular system which operate over different scales of observation. The aim of this work is to examine asymmetry phenomenon in heart failure (HF) patients with sinus rhythm. We computed Guzik's index of heart rate asymmetry related to HR deceleration (Cd) from the Poincare plot (Pp) analysis extended up to 20th order. In the control group asymmetry is maintained over all orders of the Pp. In HF patients with asymmetric properties, Cd is reduced in the range between 2nd and 5th order of the Pp analysis, compared the control subjects. More, this method revealed two clusters of HF patients. In conclusion, proposed new approach can be applied to reveal alterations in the behavior of the cardiovascular control mechanisms in pathological conditions.",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
journal = "2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Mod",
title = "Asymmetry of Cardiac Interbeat Intervals in Heart Failure",
doi = "10.1109/ESGCO49734.2020.9158154"
}

Platisa, M. M., Radovanović, N.N., Kalauzi, A., Milasinović, G.,& Pavlović, S.U.. (2020). Asymmetry of Cardiac Interbeat Intervals in Heart Failure. in 2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Mod
Institute of Electrical and Electronics Engineers Inc...
https://doi.org/10.1109/ESGCO49734.2020.9158154

Platisa MM, Radovanović N, Kalauzi A, Milasinović G, Pavlović S. Asymmetry of Cardiac Interbeat Intervals in Heart Failure. in 2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Mod. 2020;.
doi:10.1109/ESGCO49734.2020.9158154 .

Platisa, Mirjana M., Radovanović, N.N., Kalauzi, Aleksandar, Milasinović, G., Pavlović, S.U., "Asymmetry of Cardiac Interbeat Intervals in Heart Failure" in 2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Mod (2020),
https://doi.org/10.1109/ESGCO49734.2020.9158154 . .

TY  - JOUR
AU  - Platisa, Mirjana M.
AU  - Radovanović, Nikola N.
AU  - Kalauzi, Aleksandar
AU  - Milasinović, Goran
AU  - Pavlović, Sinisa U.
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1328
AB  - It is known that in pathological conditions, physiological systems develop changes in the multiscale properties of physiological signals. However, in real life, little is known about how changes in the function of one of the two coupled physiological systems induce changes in function of the other one, especially on their multiscale behavior. Hence, in this work we aimed to examine the complexity of cardio-respiratory coupled systems control using multiscale entropy (MSE) analysis of cardiac intervals MSE (RR), respiratory time series MSE (Resp), and synchrony of these rhythms by cross multiscale entropy (CMSE) analysis, in the heart failure (HF) patients and healthy subjects. We analyzed 20 min of synchronously recorded RR intervals and respiratory signal during relaxation in the supine position in 42 heart failure patients and 14 control healthy subjects. Heart failure group was divided into three subgroups, according to the RR interval time series characteristics (atrial fibrillation (HFAF), sinus rhythm (HFSin), and sinus rhythm with ventricular extrasystoles (HFVES)). Compared with healthy control subjects, alterations in respiratory signal properties were observed in patients from the HFSin and HFVES groups. Further, mean MSE curves of RR intervals and respiratory signal were not statistically different only in the HFSin group (p = 0.43). The level of synchrony between these time series was significantly higher in HFSin and HFVES patients than in control subjects and HFAF patients (p  lt  0.01). In conclusion, depending on the specific pathologies, primary alterations in the regularity of cardiac rhythm resulted in changes in the regularity of the respiratory rhythm, as well as in the level of their asynchrony.
PB  - MDPI, Basel
T2  - Entropy
T1  - Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling
IS  - 9
VL  - 22
DO  - 10.3390/e22091042
ER  - 

@article{
author = "Platisa, Mirjana M. and Radovanović, Nikola N. and Kalauzi, Aleksandar and Milasinović, Goran and Pavlović, Sinisa U.",
year = "2020",
abstract = "It is known that in pathological conditions, physiological systems develop changes in the multiscale properties of physiological signals. However, in real life, little is known about how changes in the function of one of the two coupled physiological systems induce changes in function of the other one, especially on their multiscale behavior. Hence, in this work we aimed to examine the complexity of cardio-respiratory coupled systems control using multiscale entropy (MSE) analysis of cardiac intervals MSE (RR), respiratory time series MSE (Resp), and synchrony of these rhythms by cross multiscale entropy (CMSE) analysis, in the heart failure (HF) patients and healthy subjects. We analyzed 20 min of synchronously recorded RR intervals and respiratory signal during relaxation in the supine position in 42 heart failure patients and 14 control healthy subjects. Heart failure group was divided into three subgroups, according to the RR interval time series characteristics (atrial fibrillation (HFAF), sinus rhythm (HFSin), and sinus rhythm with ventricular extrasystoles (HFVES)). Compared with healthy control subjects, alterations in respiratory signal properties were observed in patients from the HFSin and HFVES groups. Further, mean MSE curves of RR intervals and respiratory signal were not statistically different only in the HFSin group (p = 0.43). The level of synchrony between these time series was significantly higher in HFSin and HFVES patients than in control subjects and HFAF patients (p  lt  0.01). In conclusion, depending on the specific pathologies, primary alterations in the regularity of cardiac rhythm resulted in changes in the regularity of the respiratory rhythm, as well as in the level of their asynchrony.",
publisher = "MDPI, Basel",
journal = "Entropy",
title = "Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling",
number = "9",
volume = "22",
doi = "10.3390/e22091042"
}

Platisa, M. M., Radovanović, N. N., Kalauzi, A., Milasinović, G.,& Pavlović, S. U.. (2020). Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling. in Entropy
MDPI, Basel., 22(9).
https://doi.org/10.3390/e22091042

Platisa MM, Radovanović NN, Kalauzi A, Milasinović G, Pavlović SU. Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling. in Entropy. 2020;22(9).
doi:10.3390/e22091042 .

Platisa, Mirjana M., Radovanović, Nikola N., Kalauzi, Aleksandar, Milasinović, Goran, Pavlović, Sinisa U., "Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling" in Entropy, 22, no. 9 (2020),
https://doi.org/10.3390/e22091042 . .

TY  - JOUR
AU  - Matic, Zoran
AU  - Platisa, Mirjana M.
AU  - Kalauzi, Aleksandar
AU  - Bojic, Tijana
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1293
AB  - Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, alpha(1RRI), alpha(2RRI), alpha(1Resp), alpha(2Resp)), Multiple Scaling Entropy (MSERRI1-4, MSERRI5-10, MSEResp1-4, MSEResp5-10), spectral coherence (Coh(RRI-Resp)), cross DFA (rho(1) and rho(2)) and cross MSE (XMSE1-4 and XMSE5-10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of Coh(RRI-Resp) and insensitivity to change of in rho(1), rho(2), XMSE1-4, and XMSE5-10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. Coh(RRI-Resp) did not change with respect to supine position, while rho(1) increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Physiology
T1  - Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling
VL  - 11
DO  - 10.3389/fphys.2020.00024
ER  - 

@article{
author = "Matic, Zoran and Platisa, Mirjana M. and Kalauzi, Aleksandar and Bojic, Tijana",
year = "2020",
abstract = "Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, alpha(1RRI), alpha(2RRI), alpha(1Resp), alpha(2Resp)), Multiple Scaling Entropy (MSERRI1-4, MSERRI5-10, MSEResp1-4, MSEResp5-10), spectral coherence (Coh(RRI-Resp)), cross DFA (rho(1) and rho(2)) and cross MSE (XMSE1-4 and XMSE5-10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of Coh(RRI-Resp) and insensitivity to change of in rho(1), rho(2), XMSE1-4, and XMSE5-10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. Coh(RRI-Resp) did not change with respect to supine position, while rho(1) increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Physiology",
title = "Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling",
volume = "11",
doi = "10.3389/fphys.2020.00024"
}

Matic, Z., Platisa, M. M., Kalauzi, A.,& Bojic, T.. (2020). Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling. in Frontiers in Physiology
Frontiers Media Sa, Lausanne., 11.
https://doi.org/10.3389/fphys.2020.00024

Matic Z, Platisa MM, Kalauzi A, Bojic T. Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling. in Frontiers in Physiology. 2020;11.
doi:10.3389/fphys.2020.00024 .

Matic, Zoran, Platisa, Mirjana M., Kalauzi, Aleksandar, Bojic, Tijana, "Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling" in Frontiers in Physiology, 11 (2020),
https://doi.org/10.3389/fphys.2020.00024 . .