@article{
author = "Todorović, Tamara and Vukašinović, Jelena and Portalone, Gustavo and suleiman, sherif and Gligorijević, Nevenka and Bjelogrlic, Snezana K. and Jovanovic, Katarina and Radulović, Sinisa S and Andjelkovic, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-WIsmayer, Pierre",
year = "2017",
abstract = "Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin.",
publisher = "RSC Publishing",
journal = "MedChemComm",
title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines",
pages = "111-103",
number = "1",
volume = "8",
doi = "https://doi.org/10.1039/c6md00501b"
}