TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Kojić, Vesna
AU  - Jakimov, Dimitar
AU  - Lazović, Milica
AU  - Tommonaro, Giuseppina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/953
AB  - The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro evaluation of cytotoxic and mutagenic activity of avarol
EP  - 1296
IS  - 11
SP  - 1293
VL  - 30
DO  - 10.1080/14786419.2015.1052067
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Kojić, Vesna and Jakimov, Dimitar and Lazović, Milica and Tommonaro, Giuseppina",
year = "2016",
abstract = "The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro evaluation of cytotoxic and mutagenic activity of avarol",
pages = "1296-1293",
number = "11",
volume = "30",
doi = "10.1080/14786419.2015.1052067"
}

Pejin, B., Iodice, C., Kojić, V., Jakimov, D., Lazović, M.,& Tommonaro, G.. (2016). In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(11), 1293-1296.
https://doi.org/10.1080/14786419.2015.1052067

Pejin B, Iodice C, Kojić V, Jakimov D, Lazović M, Tommonaro G. In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research. 2016;30(11):1293-1296.
doi:10.1080/14786419.2015.1052067 .

Pejin, Boris, Iodice, Carmine, Kojić, Vesna, Jakimov, Dimitar, Lazović, Milica, Tommonaro, Giuseppina, "In vitro evaluation of cytotoxic and mutagenic activity of avarol" in Natural Product Research, 30, no. 11 (2016):1293-1296,
https://doi.org/10.1080/14786419.2015.1052067 . .