In vitro evaluation of cytotoxic and mutagenic activity of avarol
Nema prikaza
Autori
Pejin, BorisIodice, Carmine
Kojić, Vesna
Jakimov, Dimitar
Lazović, Milica
Tommonaro, Giuseppina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.
Ključne reči:
sesquiterpenoid hydroquinone / human tumours / Dysidea avara / comet assayIzvor:
Natural Product Research, 2016, 30, 11, 1293-1296Izdavač:
- Taylor & Francis Ltd, Abingdon
Finansiranje / projekti:
- Sinteza i biološka ispitivanja novih mimetika ili derivata odabranih citotoksičnih laktona, antitumorskog agensa tiazofurina i prirodnih naftnih kiselina (RS-172006)
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
DOI: 10.1080/14786419.2015.1052067
ISSN: 1478-6419
PubMed: 26181496
WoS: 000375568000010
Scopus: 2-s2.0-84937115879
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Iodice, Carmine AU - Kojić, Vesna AU - Jakimov, Dimitar AU - Lazović, Milica AU - Tommonaro, Giuseppina PY - 2016 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/953 AB - The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature. PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - In vitro evaluation of cytotoxic and mutagenic activity of avarol EP - 1296 IS - 11 SP - 1293 VL - 30 DO - 10.1080/14786419.2015.1052067 ER -
@article{ author = "Pejin, Boris and Iodice, Carmine and Kojić, Vesna and Jakimov, Dimitar and Lazović, Milica and Tommonaro, Giuseppina", year = "2016", abstract = "The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "In vitro evaluation of cytotoxic and mutagenic activity of avarol", pages = "1296-1293", number = "11", volume = "30", doi = "10.1080/14786419.2015.1052067" }
Pejin, B., Iodice, C., Kojić, V., Jakimov, D., Lazović, M.,& Tommonaro, G.. (2016). In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research Taylor & Francis Ltd, Abingdon., 30(11), 1293-1296. https://doi.org/10.1080/14786419.2015.1052067
Pejin B, Iodice C, Kojić V, Jakimov D, Lazović M, Tommonaro G. In vitro evaluation of cytotoxic and mutagenic activity of avarol. in Natural Product Research. 2016;30(11):1293-1296. doi:10.1080/14786419.2015.1052067 .
Pejin, Boris, Iodice, Carmine, Kojić, Vesna, Jakimov, Dimitar, Lazović, Milica, Tommonaro, Giuseppina, "In vitro evaluation of cytotoxic and mutagenic activity of avarol" in Natural Product Research, 30, no. 11 (2016):1293-1296, https://doi.org/10.1080/14786419.2015.1052067 . .