In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract
Nema prikaza
Autori
Pejin, BorisStosic-Grujicic, Stanislava
Bogdanović, Gordana
Hegediš, Aleksandar
Karaman, I.
Stojanović, I.
Nikolić, Ivan
Kojic, V.
Horvatović, Mladen
Radotić, Ksenija
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.
Ključne reči:
Proliferation / Nitric oxide / MCF-7 cells / Macrophages / LymphocytesIzvor:
Digest Journal of Nanomaterials and Biostructures, 2012, 8, 1, 187-195Izdavač:
- Inst Materials Physics
Finansiranje / projekti:
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
- Interakcije membrana sa unutarćelijskim i apoplastičnim prostorom: izučavanja bioenergetike i singalizacije koristeći biofizičke i biohemijske metode (RS-MESTD-Basic Research (BR or ON)-173040)
- Sinteza i biološka ispitivanja novih mimetika ili derivata odabranih citotoksičnih laktona, antitumorskog agensa tiazofurina i prirodnih naftnih kiselina (RS-MESTD-Basic Research (BR or ON)-172006)
- Istraživanje klimatskih promena i njihovog uticaja na životnu sredinu - praćenje uticaja, adaptacija i ublažavanje (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43007)
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Stosic-Grujicic, Stanislava AU - Bogdanović, Gordana AU - Hegediš, Aleksandar AU - Karaman, I. AU - Stojanović, I. AU - Nikolić, Ivan AU - Kojic, V. AU - Horvatović, Mladen AU - Radotić, Ksenija PY - 2012 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/619 AB - The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation. PB - Inst Materials Physics T2 - Digest Journal of Nanomaterials and Biostructures T1 - In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract EP - 195 IS - 1 SP - 187 VL - 8 UR - https://hdl.handle.net/21.15107/rcub_rimsi_619 ER -
@article{ author = "Pejin, Boris and Stosic-Grujicic, Stanislava and Bogdanović, Gordana and Hegediš, Aleksandar and Karaman, I. and Stojanović, I. and Nikolić, Ivan and Kojic, V. and Horvatović, Mladen and Radotić, Ksenija", year = "2012", abstract = "The immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 mu g/ml and 9.7 mu g/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 mu g/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.", publisher = "Inst Materials Physics", journal = "Digest Journal of Nanomaterials and Biostructures", title = "In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract", pages = "195-187", number = "1", volume = "8", url = "https://hdl.handle.net/21.15107/rcub_rimsi_619" }
Pejin, B., Stosic-Grujicic, S., Bogdanović, G., Hegediš, A., Karaman, I., Stojanović, I., Nikolić, I., Kojic, V., Horvatović, M.,& Radotić, K.. (2012). In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract. in Digest Journal of Nanomaterials and Biostructures Inst Materials Physics., 8(1), 187-195. https://hdl.handle.net/21.15107/rcub_rimsi_619
Pejin B, Stosic-Grujicic S, Bogdanović G, Hegediš A, Karaman I, Stojanović I, Nikolić I, Kojic V, Horvatović M, Radotić K. In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract. in Digest Journal of Nanomaterials and Biostructures. 2012;8(1):187-195. https://hdl.handle.net/21.15107/rcub_rimsi_619 .
Pejin, Boris, Stosic-Grujicic, Stanislava, Bogdanović, Gordana, Hegediš, Aleksandar, Karaman, I., Stojanović, I., Nikolić, Ivan, Kojic, V., Horvatović, Mladen, Radotić, Ksenija, "In vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan hyalinella punctata methanolic extract" in Digest Journal of Nanomaterials and Biostructures, 8, no. 1 (2012):187-195, https://hdl.handle.net/21.15107/rcub_rimsi_619 .