Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy
Authors
Savic, DanijelaOpačić, Miloš
Ristic, Aleksandar J
Sokic, Dragoslav
Bascarevic, Vladimir
Raičević, Savo
Savić, Slobodan
Živin, Marko
Šelih, Vid Simon
Spasic, Snezana
Spasojević, Ivan
Conference object (Published version)
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The accumulating evidence on the relation between the disturbed metal homeostasis and epilepsy urges the need for data regarding the total metal concentrations, as well as metal distribution in the brain itself, in order to indicate where to direct the potential therapy, to metal supplementation or chelation. This paper summarizes our results on the measurements of some important essential metals in hippocampi of patients with mesial temporal lobe epilepsy (mTLE) who underwent amigdalohippocampectomy. The key findings point out that levels of copper and manganese are deficient in hippocampi of mTLE patients, and that their concentrations correlated positively with neuronal loss in affected regions of sclerotic hippocampus. In addition, the Cu concentration was decreased in the areas of total neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor deficient compared to control. Our results contribute to deeper insight of metals biology in the epilepsy and may ...represent the initial point of new and non-invasive therapy of drug resistant epilepsy.
Keywords:
epilepsy neuronal loss mTLESource:
Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia, 2018, 105-112Publisher:
- Biohemijsko društvo Srbije
Funding / projects:
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
- Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-MESTD-Basic Research (BR or ON)-173014)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200171 (Institute for Byzantine Studies SASA, Belgrade) (RS-MESTD-inst-2020-200171)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200034 (University of Belgrade, 'Mihajlo Pupin' Institute) (RS-MESTD-inst-2020-200034)
- Slovenian Research Agency (ARRS)
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Institution/Community
Institut za multidisciplinarna istraživanjaTY - CONF AU - Savic, Danijela AU - Opačić, Miloš AU - Ristic, Aleksandar J AU - Sokic, Dragoslav AU - Bascarevic, Vladimir AU - Raičević, Savo AU - Savić, Slobodan AU - Živin, Marko AU - Šelih, Vid Simon AU - Spasic, Snezana AU - Spasojević, Ivan PY - 2018 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2961 AB - The accumulating evidence on the relation between the disturbed metal homeostasis and epilepsy urges the need for data regarding the total metal concentrations, as well as metal distribution in the brain itself, in order to indicate where to direct the potential therapy, to metal supplementation or chelation. This paper summarizes our results on the measurements of some important essential metals in hippocampi of patients with mesial temporal lobe epilepsy (mTLE) who underwent amigdalohippocampectomy. The key findings point out that levels of copper and manganese are deficient in hippocampi of mTLE patients, and that their concentrations correlated positively with neuronal loss in affected regions of sclerotic hippocampus. In addition, the Cu concentration was decreased in the areas of total neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor deficient compared to control. Our results contribute to deeper insight of metals biology in the epilepsy and may represent the initial point of new and non-invasive therapy of drug resistant epilepsy. PB - Biohemijsko društvo Srbije C3 - Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia T1 - Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy EP - 112 SP - 105 UR - https://hdl.handle.net/21.15107/rcub_rimsi_2961 ER -
@conference{ author = "Savic, Danijela and Opačić, Miloš and Ristic, Aleksandar J and Sokic, Dragoslav and Bascarevic, Vladimir and Raičević, Savo and Savić, Slobodan and Živin, Marko and Šelih, Vid Simon and Spasic, Snezana and Spasojević, Ivan", year = "2018", abstract = "The accumulating evidence on the relation between the disturbed metal homeostasis and epilepsy urges the need for data regarding the total metal concentrations, as well as metal distribution in the brain itself, in order to indicate where to direct the potential therapy, to metal supplementation or chelation. This paper summarizes our results on the measurements of some important essential metals in hippocampi of patients with mesial temporal lobe epilepsy (mTLE) who underwent amigdalohippocampectomy. The key findings point out that levels of copper and manganese are deficient in hippocampi of mTLE patients, and that their concentrations correlated positively with neuronal loss in affected regions of sclerotic hippocampus. In addition, the Cu concentration was decreased in the areas of total neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor deficient compared to control. Our results contribute to deeper insight of metals biology in the epilepsy and may represent the initial point of new and non-invasive therapy of drug resistant epilepsy.", publisher = "Biohemijsko društvo Srbije", journal = "Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia", title = "Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy", pages = "112-105", url = "https://hdl.handle.net/21.15107/rcub_rimsi_2961" }
Savic, D., Opačić, M., Ristic, A. J., Sokic, D., Bascarevic, V., Raičević, S., Savić, S., Živin, M., Šelih, V. S., Spasic, S.,& Spasojević, I.. (2018). Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia Biohemijsko društvo Srbije., 105-112. https://hdl.handle.net/21.15107/rcub_rimsi_2961
Savic D, Opačić M, Ristic AJ, Sokic D, Bascarevic V, Raičević S, Savić S, Živin M, Šelih VS, Spasic S, Spasojević I. Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia. 2018;:105-112. https://hdl.handle.net/21.15107/rcub_rimsi_2961 .
Savic, Danijela, Opačić, Miloš, Ristic, Aleksandar J, Sokic, Dragoslav, Bascarevic, Vladimir, Raičević, Savo, Savić, Slobodan, Živin, Marko, Šelih, Vid Simon, Spasic, Snezana, Spasojević, Ivan, "Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy" in Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia (2018):105-112, https://hdl.handle.net/21.15107/rcub_rimsi_2961 .