Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression
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Background: ALS is an oxidative stress-related fastpaced
motor neuron disease for which there are no
accurate biomarkers of progression. This largely hampers
the development of therapeutics. Our aim was to test the
applicability of oxidation-reduction potential (ORP) of
cerebrospinal fluid (CSF) in ALS progression follow-up.
Methods: ORP was measured using RedoxSYS (Aytu
BioScience, Inc.) in CSF of 49 ALS patients (mean age
63 1.29 years; range 43-80 years; mean ALSFRSr score
37.47 0.90, range 21-48; m/f = 35/14) and 15 controls
(mean age 48.93 3.68 years, range 21-67 years; m/f =
10/5).
Results: Pearson correlation coefficient (R) between
ALSFRSr score and ORP was 0.27 (p = 0.06). R was
higher ( 0.45) when two outlier values were excluded
from the calculus. Importantly, ALS patients had significantly
higher mean ORP (ALS: 121.83 2.76mV;
controls: 111.14 2.94 mV; p = 0.033). The difference
was also significant for ORP normalized to age. Of note,
ORP is reciprocally p...roportional to the pro-oxidative
settings in biological samples.
Discussion: Increased ORP values in ALS patients
further confirm the role of oxidative stress in this
neurodegenerative disease. ORP might find application
as a biomarker for ALS progression/prognosis but further
measurements on a larger cohort is warranted.
Keywords:
ALS ORP biomarkerSource:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2016, 183-Publisher:
- Taylor and Francis
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Institut za multidisciplinarna istraživanjaTY - CONF AU - Opačić, Miloš AU - Stevic, Zorica AU - Živić, Miroslav AU - Spasojević, Ivan PY - 2016 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2957 AB - Background: ALS is an oxidative stress-related fastpaced motor neuron disease for which there are no accurate biomarkers of progression. This largely hampers the development of therapeutics. Our aim was to test the applicability of oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) in ALS progression follow-up. Methods: ORP was measured using RedoxSYS (Aytu BioScience, Inc.) in CSF of 49 ALS patients (mean age 63 1.29 years; range 43-80 years; mean ALSFRSr score 37.47 0.90, range 21-48; m/f = 35/14) and 15 controls (mean age 48.93 3.68 years, range 21-67 years; m/f = 10/5). Results: Pearson correlation coefficient (R) between ALSFRSr score and ORP was 0.27 (p = 0.06). R was higher ( 0.45) when two outlier values were excluded from the calculus. Importantly, ALS patients had significantly higher mean ORP (ALS: 121.83 2.76mV; controls: 111.14 2.94 mV; p = 0.033). The difference was also significant for ORP normalized to age. Of note, ORP is reciprocally proportional to the pro-oxidative settings in biological samples. Discussion: Increased ORP values in ALS patients further confirm the role of oxidative stress in this neurodegenerative disease. ORP might find application as a biomarker for ALS progression/prognosis but further measurements on a larger cohort is warranted. PB - Taylor and Francis C3 - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration T1 - Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression SP - 183 DO - 10.1080/21678421.2016.1232061 ER -
@conference{ author = "Opačić, Miloš and Stevic, Zorica and Živić, Miroslav and Spasojević, Ivan", year = "2016", abstract = "Background: ALS is an oxidative stress-related fastpaced motor neuron disease for which there are no accurate biomarkers of progression. This largely hampers the development of therapeutics. Our aim was to test the applicability of oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) in ALS progression follow-up. Methods: ORP was measured using RedoxSYS (Aytu BioScience, Inc.) in CSF of 49 ALS patients (mean age 63 1.29 years; range 43-80 years; mean ALSFRSr score 37.47 0.90, range 21-48; m/f = 35/14) and 15 controls (mean age 48.93 3.68 years, range 21-67 years; m/f = 10/5). Results: Pearson correlation coefficient (R) between ALSFRSr score and ORP was 0.27 (p = 0.06). R was higher ( 0.45) when two outlier values were excluded from the calculus. Importantly, ALS patients had significantly higher mean ORP (ALS: 121.83 2.76mV; controls: 111.14 2.94 mV; p = 0.033). The difference was also significant for ORP normalized to age. Of note, ORP is reciprocally proportional to the pro-oxidative settings in biological samples. Discussion: Increased ORP values in ALS patients further confirm the role of oxidative stress in this neurodegenerative disease. ORP might find application as a biomarker for ALS progression/prognosis but further measurements on a larger cohort is warranted.", publisher = "Taylor and Francis", journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration", title = "Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression", pages = "183", doi = "10.1080/21678421.2016.1232061" }
Opačić, M., Stevic, Z., Živić, M.,& Spasojević, I.. (2016). Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression. in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Taylor and Francis., 183. https://doi.org/10.1080/21678421.2016.1232061
Opačić M, Stevic Z, Živić M, Spasojević I. Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression. in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2016;:183. doi:10.1080/21678421.2016.1232061 .
Opačić, Miloš, Stevic, Zorica, Živić, Miroslav, Spasojević, Ivan, "Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression" in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2016):183, https://doi.org/10.1080/21678421.2016.1232061 . .